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Facial edema as an adverse drug reaction to olanzapine in a patient with cancer receiving palliative care

Published online by Cambridge University Press:  03 March 2022

Miguel Julião Open the ORCID record for Miguel Julião [Opens in a new window] ,
Maria Ana Sobral ,
Tiago Ferreira ,
Patrícia Calaveiras ,
Elisabeth Costa ,
Ana Sara Daniel ,
Mafalda Lemos-Caldas Open the ORCID record for Mafalda Lemos-Caldas [Opens in a new window]  and
Eduardo Bruera
Miguel Julião*
Affiliation:
Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra, Sintra, Portugal
Maria Ana Sobral
Affiliation:
Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra, Sintra, Portugal
Tiago Ferreira
Affiliation:
Departamento de Saúde Mental, Hospital Prof. Doutor Fernando da Fonseca EPE, Amadora, Portugal
Patrícia Calaveiras
Affiliation:
Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra, Sintra, Portugal
Elisabeth Costa
Affiliation:
Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra, Sintra, Portugal
Ana Sara Daniel
Affiliation:
Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra, Sintra, Portugal
Mafalda Lemos-Caldas
Affiliation:
ACeS Loures-Odivelas, USF Travessa da Saúde, Lisboa, Portugal
Eduardo Bruera
Affiliation:
Department of Palliative, Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX
*
Author for correspondence: Miguel Julião, Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra 2635-364 Rio de Mouro, Sintra, Portugal. E-mail: migueljuliao@gmail.com
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Abstract

Objective

Atypical neuroleptics such as olanzapine are indicated for the treatment of various psychiatric disorders and have been used in the palliative care setting also for several clinical indications. Peripheral and facial edema are a rare side effect of the treatment with olanzapine. We report a case of an advanced cancer patient cared receiving palliative care who developed severe facial edema after initiating a low dose of olanzapine in monotherapy.

Method

A patient with advanced cancer who presented with severe facial edema after initiating olanzapine for the treatment of her opioid use disorder.

Results

After excluding other differential diagnosis for facial edema, olanzapine was discontinued with complete resolution of the edema.

Significance of results

To the best of our knowledge, this is the first case reporting facial edema due to olanzapine treatment in a patient with advanced cancer. Our report will help clinicians recognize the possible role of olanzapine in cases of rapid onset of facial edema, allowing its rapid resolution.

Keywords

CancerCase reportFacial edemaOlanzapinePalliative careTerminally ill
Type
Case Report
Information
Palliative & Supportive Care , Volume 20 , Issue 5 , October 2022 , pp. 752 - 753
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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