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How Did It All Begin: The Self-assembly of Organic Molecules and the Origin of Cellular Life

Published online by Cambridge University Press:  26 July 2017

David W. Deamer*
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064
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Movies are the myths of late-20th century western culture. Because of the power of films like ET to capture our imagination, we are more likely than past generations to accept the possibility that life exists elsewhere in our galaxy. Such a myth can be used to sketch the main themes of this chapter, which concern the origin of life on the Earth.

Imagine that 4 billion years ago, intelligent beings evolved on an Earth-like planet in the solar system of a neighboring star. After ten million years of evolution, they have solved the problems of interstellar travel and aging. Virtually immortal family groups set out to explore the galaxy and almost immediately discover a solar system associated with a nearby star only 80 light years away from their home planet. They find that the third planet is rich in the primary elements of life - carbon, hydrogen, oxygen and nitrogen - which are present in the atmosphere in the form of carbon dioxide (CO2), molecular nitrogen (N2) and water vapor (H2O). They decide to spend a few centuries studying this planet, which they consider to be a possible model of their own primordial world as it was four billion years in their past.

Evidence for Evolution
Copyright © 1999 by The Paleontological Society 

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References Cited

Anders, E. Pre-biotic organic matter from comets and asteroids. 1989. Nature 342: 255257.CrossRefGoogle ScholarPubMed
Bada, J.L., Bigham, C. and Miller, S.L. 1994. Impact melting of frozen oceans on the early Earth - Implications for the origin of life. Proc. Natl. Acad. Sci. USA. 91: 1248.CrossRefGoogle ScholarPubMed
Baross, J.A. and Hoffman, S.E. 1995. Submarine hydrothermal vents and associated gradient environments as sites for the origin and evolution of life. Origins of Life. 15: 327.Google Scholar
Beaudry, A. A. and Joyce, G. F. 1992. Directed evolution of an RNA enzyme. Science 342: 255257.Google Scholar
Been, M.D. and Cech, T.R. 1988. Science 239: 1412.CrossRefGoogle Scholar
Chakrabarti, A., Breaker, R.R., Joyce, G.F. and Deamer, D.W. 1994. Production of RNA by a polymerase protein encapsulated within phospholipid vesicles. J. Mol. Evol. 39: 555559.CrossRefGoogle ScholarPubMed
Chyba, C.F. and Sagan, C. 1992. Endogenous production, exogenous delivery and impact-shock synthesis of organic molecules: An inventory for the origin of life. Nature 355: 125–13.CrossRefGoogle Scholar
Corliss, J.B., Baross, J.A. and Hoffman, S.E. 1981. An hypothesis concerning the relationship between submarine hot springs and the origin of life on Earth. Oceanol. p 59. Acta. Proc. 26th Intl. Geolog. Congress, Geology of the Oceans symposium, Paris.Google Scholar
Cronin, J.R., Pizzarello, S., and Cruickshank, D.P. 1988. Organic matter in carbonaceous chondrites, planetary satellites, asteroids and comets. In Meteorites and the Early Solar System, Kerridge, J. F. and Matthews, M. S., (eds.) University of Arizona Press, Tucson AZ. 819857.Google Scholar
Deamer, D.W. 1999. The first living organisms: In the light or in the dark? ChemTracts (In press) Google Scholar
Deamer, D.W. 1998. Membrane compartments in prebiotic evolution. In: The Molecular Origins of Life, Brack, A., (ed.) Cambridge UK: Cambridge University Press. pp. 189205.CrossRefGoogle Scholar
Delsemme, A. 1984. The cometary connection with prebiotic chemistry. Origins of Life 14:5160.CrossRefGoogle Scholar
Ferris, J.P. and Hagan, W.J. 1984. HCN and chemical evolution: The possible role of cyano compounds in prebiotic synthesis. Tetrahedron 40: 1093.CrossRefGoogle ScholarPubMed
Fox, S. W. and Harada, K. 1958. Thermal copolymerization of amino acids to a product resembling protein. Science 128: 1214.CrossRefGoogle ScholarPubMed
Gavino, V. and Deamer, D.W. 1982. Purification of acyl CoA:1-acyl-sn-glycerophosphorylcholine acyltransferase. J. Bioenerg. Biomembr. 14:513526.CrossRefGoogle ScholarPubMed
Goldacre, R.J. 1958. Surface films: Their collapse on compression, the shapes and sizes of cells, and the origin of life. p. 1227. In Surface Phenomena in Biology and Chemistry, Danielli, J. F., Pankhurst, K.G.A., and Riddiford, A. C., (eds.). Pergamon Press, New York. pp. 12–27.Google Scholar
Haldane, J.B.S. 1929. The Origin of Life. The Rationalist Annual 148: 310.Google Scholar
Hargreaves, W.R., and Deamer, D.W. 1978. Liposomes from ionic, single-chain amphiphiles. Biochemistry 17:37593768.CrossRefGoogle ScholarPubMed
Hargreaves, W.R., Mulvihill, S. and Deamer, D.W. 1977. Nature. Synthesis of phospholipids and membranes in prebiotic conditions. Nature 266:7880.CrossRefGoogle ScholarPubMed
Holland, H.D. 1984. The Chemical Evolution of the Atmosphere and Oceans. Princeton University Press, Princeton, NJ.Google ScholarPubMed
Joyce, G. F., Schwartz, A. W., Miller, S.L. and Orgel, L.E. 1987. The case for an ancestral genetic system involving simple analogues of the nucleotides. Proc. Natl. Acad. Sci. USA 84: 4398.CrossRefGoogle ScholarPubMed
Kasting, J. and Ackerman, T.F. 1986. Climatic consequences of very high carbon dioxide levels in the Earth's early atmosphere. Science 234: 1383.CrossRefGoogle ScholarPubMed
Kvenvolden, K.A., Lawless, J.G., Pering, K., Peterson, E., Flores, J., Ponnamperuma, C., Kaplan, I.R. and Moore, C. 1970. Evidence for extraterrestrial amino acids and hydrocarbons in the Murchison meteorite. Nature 28: 923.CrossRefGoogle Scholar
Miller, S. L. 1953. Production of amino acids under possible primitive Earth conditions. Science 117: 528.CrossRefGoogle ScholarPubMed
Miller, S. L. and Urey, H. C. 1959. Organic compounds synthesized on the primitive Earth. Science 130: 245.CrossRefGoogle Scholar
Mojzsis, S.J. Arrhenius, G., McKeegan, K.D. and Harrison, T.M. 1996. Nature 384: 55.CrossRefGoogle Scholar
Monnard, P.-A., Vercoutere, W. and Deamer, D.W. (Unpublished results.) Google Scholar
Oro, J. 1961. Comets and the formation of biochemical compounds on the primitive Earth. Nature 190: 389390.CrossRefGoogle Scholar
Oro, J., Sherwood, E., Eichberg, J. and Epps, D. 1978. Formation of phospholipids under primitive Earth conditions and the role of membranes in prebiological evolution. In Light-Transducing Membranes: Structure, Function and Evolution, Deamer, D.W. (ed.) New York: Academic Press. pp. 121.Google Scholar
Pace, N.R. 1991. Origin of life - Facing up to the physical setting. Cell 65: 531.CrossRefGoogle ScholarPubMed
Pace, N.R. Science 1997, 276, 734.Google Scholar
Paula, S., Volkov, A.G., Van Hoek, A.N., Haines, T.H. and Deamer, D.W. 1996. Permeation of protons, potassium ions and small polar molecules through phospholipid bilayers as a function of membrane thickness. Biophys. J. 70: 339348.CrossRefGoogle ScholarPubMed
Schopf, J.W. and Packer, B.M. 1987. Early Archean (3.3-billion to 3.5-billion-year-old) microfossils from Warrawoona Group, Australia. Science 237: 70.CrossRefGoogle ScholarPubMed
Stevens, T.O. and McKinley, J.P. 1995. Science 270: 450.CrossRefGoogle Scholar
Usher, D. 1977. Early chemical evolution of nucleic acids: A theoretical model. Science 196:311313.CrossRefGoogle ScholarPubMed
Wilson, C. and Szostak, J.W. 1994. In vitro evolution of a self-alkylating ribozyme. Nature 374: 777.CrossRefGoogle ScholarPubMed
Woese, C.R. 1987. Bacterial evolution. Microbiol. Rev. 51: 221.Google ScholarPubMed
Wright, M.C. and Joyce, G.F. Continuous in vitro evolution of catalytic function. 1997. Science 274: 1309.Google Scholar