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Oxidants, Antioxidants and Cardiovascular Disease

Published online by Cambridge University Press:  14 December 2007

G. G. Duthie
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
K. W. J. Wahle
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
W. P. T. James
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

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Type
Research Articles
Copyright
Copyright © The Nutrition Society 1989

References

Acheson, R. M. & Williams, D. D. R. (1983). Does consumption of fruit and vegetables protect against stroke? Lancet i, 11911193.CrossRefGoogle Scholar
Bang, H. O. (1988). N-3 fatty acids in the diet or as a food supplement. International Clinical Nutrition Review 8, 2128.Google Scholar
Bast, A. (1986). Is formation of reactive oxygen by cytochrome P-450 perilous and predictable? Trends in Pharmacological Science 7, 266270.CrossRefGoogle Scholar
Bendich, A. & Machlin, L. J. (1988). Safety of oral intake of vitamin E. American Journal of Clinical Nutrition 48, 612619.CrossRefGoogle ScholarPubMed
Betteridge, J. (1987). Nutrition and platelet function in atherogenesis. Proceedings of the Nutrition Society 46, 345359.CrossRefGoogle ScholarPubMed
Brown, M. S. & Goldstein, J. L. (1986). A receptor mediated pathway for cholesterol homeostasis. Science 232, 3447.CrossRefGoogle ScholarPubMed
Burk, R. F. (1978). Selenium in nutrition. World Review of Nutrition and Dietetics 30, 88106.CrossRefGoogle ScholarPubMed
Burton, G. W. (1989). Antioxidant action of carotenoids. Journal of Nutrition 119, 109111.CrossRefGoogle ScholarPubMed
Byczkowski, J. Z. & Gessner, T. (1988). Biological role of superoxide ion-radical. International Journal of Biochemistry 20, 569580.CrossRefGoogle ScholarPubMed
Church, D. F. & Pryor, W. A. (1985). Free-radical chemistry of cigarette smoke and its toxicological implications. Environmental Health Perspectives 64, 111126.CrossRefGoogle ScholarPubMed
Diplock, A. T. (1987). Dietary supplementation with antioxidants. Is there a case for exceeding the recommended dietary allowance? Free Radicals in Biology and Medicine 3, 199201.CrossRefGoogle Scholar
Dodson, P. M. & Horton, R. C. (1987). The nature of the atheroma. Proceedings of the Nutrition Society 46, 331336.CrossRefGoogle ScholarPubMed
Dubick, M. A., Hunter, G. C., Casey, S. M. & Keen, C. L. (1987). Aortic ascorbic acid, trace elements, and superoxide dismutase activity in human aneurysmal and occlusive disease. Proceedings of the Society for Experimental Biology and Medicine 184, 138143.CrossRefGoogle ScholarPubMed
Duthie, G. G., Arthur, J. R., James, W. P. T. & Vint, H. M. (1989). Antioxidant status of smokers and non-smokers: effects of vitamin E supplementation. Annals of the New York Academy of Sciences (In the Press).Google Scholar
Duthie, G. G., Arthur, J. R. & Mills, C. F. (1987). Tissue damage in vitamin E deficient rats is not detected by expired ethane and pentane. Free Radical Research Communications 4, 2125.CrossRefGoogle Scholar
Ellis, N., Lloyd, B., Lloyd, R. S. & Clayton, B. E. (1984). Selenium and vitamin E in relation to risk factors for coronary heart disease. Journal of Clinical Pathology 37, 200206.CrossRefGoogle ScholarPubMed
Forman, H. J. & Boveris, A. (1982). Superoxide radical and hydrogen peroxide in mitochondria. In Free Radicals in Biology, vol. 5, pp. 6590 [Pryor, W. A., editor]. New York: Academic Press.CrossRefGoogle Scholar
Fridovich, I. (1983). Superoxide radical: an endogenous toxicant. Annual Review of Pharmacology and Toxicology 23, 239257.CrossRefGoogle ScholarPubMed
Gey, K. F. (1986). On the antioxidant hypothesis with regard to arteriosclerosis. Bibliotheca Nutritio et Dieta 37, 5391.Google Scholar
Gey, K. F. & Brubacher, G. B. & Stähelin, H. B. (1987 a). Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. American Journal of Clinical Nutrition 45, 13681377.CrossRefGoogle ScholarPubMed
Gey, K. F. & Puska, P. (1988). Plasma vitamins E and A inversely correlated to ischemic heart disease (IHD) mortality in cross-sectional epidemiology. Annals of the New York Academy of Sciences Abstr. (In the Press).Google Scholar
Gey, K. F., Stähelin, H. B., Puska, P. & Evans, A. (1987 b). Relationship of plasma level of vitamin C to mortality from ischemic heart disease. Annals of the New York Academy of Sciences 498, 110123.CrossRefGoogle ScholarPubMed
Glavind, J., Hartmann, S., Clemmesen, J., Jessen, K. E. & Dam, H. (1952). Role of lipoperoxidases in human pathology. II. The presence of peroxidized lipids in the atherosclerotic aorta. Acta Pathologica et Microbiologica Scandinavica 30, 16.CrossRefGoogle Scholar
Grundy, S. M. (1986). Cholesterol and coronary heart disease. A new era. Journal of the American Medical Association 256, 28492858.CrossRefGoogle ScholarPubMed
Halliwell, B. (1987). Oxidants in human disease: some new concepts. FASEB Journal 1, 358364.CrossRefGoogle ScholarPubMed
Halliwell, B. & Grootveld, M. (1987). The measurement of free radical reactions in humans. Some thoughts for future experimentation. FEBS Letters 213, 914.CrossRefGoogle ScholarPubMed
Halliwell, B. & Gutteridge, M. C. (1985). Free Radicals in Biology and Medicine. Oxford: Clarendon Press.Google Scholar
Heinecke, J. W. (1987). Free radical modification of low-density lipoprotein: mechanisms and biological consequences. Free Radicals in Biology and Medicine 3, 6573.CrossRefGoogle ScholarPubMed
Heinecke, J. W., Baker, L., Rosen, H. & Chait, A. (1986). Superoxide mediated modification of low density lipoprotein by arterial smooth muscle cells. Journal of Clinical Investigation 77, 757761.CrossRefGoogle ScholarPubMed
Hennig, B. & Chow, C. K. (1988). Lipid peroxidation and endothelial cell injury: implications in atherosclerosis. Free Radicals in Biology and Medicine 4, 99106.CrossRefGoogle ScholarPubMed
Hennig, B., Enoch, C. & Chow, C. K. (1986). Linoleic acid hydroperoxide increases the transfer of albumin across cultured endothelial monolayers. Archives of Biochemistry and Biophysics 248, 353357.CrossRefGoogle ScholarPubMed
Hennig, B., Enoch, C. & Chow, C. K. (1987). Protection by vitamin E against endothelial cell injury by linoleic acid hydroperoxides. Nutrition Research 7, 12531259.CrossRefGoogle Scholar
Hiramatsu, K., Rosen, H., Heinecke, J. W., Wolfbaver, G. & Chait, A. (1987). Superoxide initiates oxidation of low density lipoprotein by human monocytes. Arteriosclerosis 7, 5560.CrossRefGoogle ScholarPubMed
Iversen, S. A., Cawood, P. & Dormandy, T. L. (1985). A method for the measurement of a diene-conjugated derivative of linoleic acid, 18:2 (9, 11), in serum phospholipid, and possible origins. Annals of Clinical Biochemistry 22, 137140.CrossRefGoogle Scholar
James, W. P. T. & Ralph, A. (1988). Should the national diet be altered to prevent coronary disease? Proceedings of the Nutrition Society 47, 38.CrossRefGoogle ScholarPubMed
Jurgens, G., Hoff, H. F., Chisholm, G. M. & Esterbauer, H. (1987). Modification of human serum low density lipoprotein by oxidation – characterization and pathophysiological implications. Chemistry and Physics of Lipids 45, 315336.CrossRefGoogle ScholarPubMed
Kallner, A. B., Hartman, D. & Hornig, D. H. (1981). On the requirements of ascorbic acid in man: steady state turnover and body pool in smokers. The American Journal of Clinical Nutrition 34, 13471355.CrossRefGoogle ScholarPubMed
Klebanoff, S. J. (1982). Oxygen-dependent cytotoxic mechanisms of phenocytes. In Advances in Host Defense Mechanisms, vol. 1, pp. 111162 [Gallin, J. I. and Fauci, A. S., editors]. New York: Raven Press.Google Scholar
Kohen, R., Yamamoto, Y., Lundy, K. C. & Ames, B. N. (1988). Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proceedings of the National Academy of Sciences of the USA 85, 31753179.CrossRefGoogle ScholarPubMed
Kok, F. J., de Bruijn, A. M., Vermeeren, R., Hofman, A., Van Laar, A., de Bruin, M., Hermus, R. J. J. & Valkenburg, H. A. (1987). Serum selenium, vitamin antioxidants, and cardiovascular mortality: a 9-year follow-up study in the Netherlands. American Journal of Clinical Nutrition 45, 462468.CrossRefGoogle ScholarPubMed
Koster, J. F. & Slee, R. G. (1986). Ferritin, a physiological iron donor for microsomal lipid peroxidation. FEBS Letters 199, 8588.CrossRefGoogle ScholarPubMed
Krinsky, N. I. (1989). Carotenoids and cancer in animal models. Journal of Nutrition 119, 123126.CrossRefGoogle ScholarPubMed
Levine, M. (1986). New concepts in the biology and biochemistry of ascorbic acid. New England Journal of Medicine 314, 892902.Google ScholarPubMed
McCormick, J. & Skrabanek, P. (1988). Coronary heart disease is not preventable by population interventions. Lancet ii, 839841.CrossRefGoogle Scholar
Miettinen, T. A., Alfthan, G., Huttunen, J. K., Pikkarainen, J., Naukkarimen, V., Mattila, S. & Kumlin, T. (1983). Serum selenium concentration related to myocardial infarction and fatty acid content of serum lipids. British Medical Journal 287, 517519.CrossRefGoogle ScholarPubMed
Mitchison, M. J. & Ball, R. Y. (1987). Macrophages and atherogenesis. Lancet ii, 146148.CrossRefGoogle Scholar
Moncada, S., Gryglewski, S., Bunting, S. & Vane, J. R. (1976). An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263, 663665.CrossRefGoogle Scholar
Pacht, E. R., Kaseki, H., Mohammed, J. R., Cornwell, D. G. & Davis, W. B. (1986). Deficiency of vitamin E in the alveolar fluid of cigarette smokers. Journal of Clinical Investigation 77, 789796.CrossRefGoogle ScholarPubMed
Palgi, A. (1981). Association between dietary changes and mortality rates: Israel 1949 to 1977: a trend-free regression model. American Journal of Clinical Nutrition 34, 15691583.CrossRefGoogle ScholarPubMed
Parker, R. S. (1989). Carotenoids in human blood and tissues. Journal of Nutrition 119, 101104.CrossRefGoogle ScholarPubMed
Pelletier, O. (1968). Smoking and vitamin C levels in humans. American Journal of Clinical Nutrition 21, 12591267.CrossRefGoogle ScholarPubMed
Quinn, M. T., Parthasarathy, S., Fong, L. G. & Steinberg, D. (1987). Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proceedings of the National Academy of Sciences of the USA 84, 29952998.CrossRefGoogle ScholarPubMed
Ramirez, J. & Flowers, N. C. (1980). Leukocyte ascorbic acid and its relationship to coronary artery disease in man. American Journal of Clinical Nutrition 33, 20792087.CrossRefGoogle ScholarPubMed
Reckless, J. P. D. (1987). Can nutrition favourably affect serum lipids? Proceedings of the Nutrition Society 46, 361366.CrossRefGoogle ScholarPubMed
Rifkind, B. M. (1987). Diet, cholesterol and coronary heart disease: the Lipid Research Clinics Programme. Proceedings of the Nutrition Society 46, 367372.CrossRefGoogle Scholar
Ringdal, O., Anderson, K. J., Svendsen, E. & Julsham, K. (1986). Trace elements and myocardial infarction, and autopsy study from Western Norway. Acta Pharmacologica et Toxicologica 59, Suppl. 7, 358360.CrossRefGoogle ScholarPubMed
Ringstad, J. (1988). Selenium in cardiovascular disease and cancer. Epidemiological and experimental studies. PhD Thesis, University of Tromsø.Google Scholar
Ringstad, J., Jacobsen, B. K., Thomassen, Y. & Thelle, D. S. (1987). The Tromsø heart study: serum selenium and risk of myocardial infarction, a nested case-control study. Journal of Epidemiology and Community Health 41, 329332.CrossRefGoogle ScholarPubMed
Robinson, M. F. & Thomson, C. D. (1983). The role of selenium in the diet. Nutrition Abstracts and Reviews 53, 326.Google Scholar
Ross, R. (1986). The pathogenesis of atherosclerosis – an update. New England Journal of Medicine 314, 488500.CrossRefGoogle ScholarPubMed
Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G. & Hoekstra, W. G. (1973). Selenium: Biochemical role as a component of glutathione peroxidase. Science 179, 588590.CrossRefGoogle ScholarPubMed
Rudel, L. L., Parks, J. S., Johnson, F. L. & Babiak, J. (1986). Low density lipoproteins in atherosclerosis. Journal of Lipid Research 27, 465474.Google ScholarPubMed
Salonen, J. T., Alfthan, G., Pikkarainen, J., Huttunen, J. K. & Puska, P. (1982). Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study. Lancet ii, 175179.CrossRefGoogle Scholar
Salonen, J. T., Salonen, R., Pentilla, I., Herranen, J., Jauhiainen, M., Kantola, M., Lappeteläinen, R., Mäenpää, P. H., Alfthan, G. & Puska, P. (1985). Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary heart disease. American Journal of Cardiology 56, 226231.CrossRefGoogle Scholar
Schoene, N. W., Morris, V. C. & Levander, O. A. (1986). Altered arachidonic acid metabolism in platelets and aortas from selenium-deficient rats. Nutrition Research 6, 7583.CrossRefGoogle Scholar
Shariff, R., Hoshino, E., Allard, J., Pichard, C., Kurian, R. & Jeejeebhoy, K. N. (1988). Vitamin E supplementation in smokers. American Journal of Clinical Nutrition 47, 758.Google Scholar
Slater, T. F. (1984). Free radical mechanisms in tissue injury. Biochemical Journal 222, 115.CrossRefGoogle ScholarPubMed
Slater, T. F., Cheeseman, K. H., Davies, M. J., Proudfoot, K. & Xin, W. (1987). Free radical mechanisms in relation to tissue injury. Proceedings of the Nutrition Society 46, 112.CrossRefGoogle ScholarPubMed
Slattery, M. L. & Randall, D. E. (1988). Trends in coronary heart disease mortality and food consumption in the United States between 1909 and 1980. American Journal of Clinical Nutrition 47, 10601067.CrossRefGoogle ScholarPubMed
Sparrow, C. P., Parthasarathy, S. & Steinberg, D. (1988). Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification. Journal of Lipid Research 29, 745753.Google ScholarPubMed
Steinbrecher, V. P., Parthasarathy, S., Leake, D. S., Witztum, J. L. & Steinberg, D. (1984). Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proceedings of the National Academy of Sciences of the USA 81, 38833887.CrossRefGoogle ScholarPubMed
Sulkin, N. M. & Sulkin, D. F. (1975). Tissue changes induced by marginal vitamin C deficiency. Annals of the New York Academy of Sciences 258, 317322.CrossRefGoogle ScholarPubMed
Tyroler, H. A. (1987). Review of lipid-lowering clinical trials in relation to observational epidemiologic studies. Circulation 76, 515522.CrossRefGoogle ScholarPubMed
van Kuijk, F. J. G. M., Sevanian, A., Handelman, G. J. & Dratz, E. A. (1987). A new role for phospholipase A2: protection of membranes from lipid peroxidation damage. Trends in Biological Science 12, 3134.CrossRefGoogle Scholar
Virtamo, J., Valkeila, E., Alfthan, G., Punsar, S., Huttunen, J. K. & Karvonen, M. J. (1985). Serum selenium and the risk of coronary heart disease and stroke. American Journal of Epidemiology 122, 276282.CrossRefGoogle ScholarPubMed
Wade, C. R. & van Rij, A. M. (1988). Plasma thiobarbituric acid reactivity: reaction conditions and the role of iron, antioxidants and lipid peroxy radicals on the quantitation of plasma lipid peroxides. Life Sciences 43, 10851093.CrossRefGoogle ScholarPubMed
Walquist, M. L. & Flint, D. M. (1983). Megavitamin therapy: What is the evidence? Patient Management 12, 103123.Google Scholar
Waterflow, J. C. (1988). General discussion. Diet and coronary disease. Proceedings of the Nutrition Society 47, 1119.CrossRefGoogle Scholar
Wayner, D. D. M., Burton, G. W., Ingold, K. U., Barclay, L. R. C. & Locke, S. J. (1987). The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochimica et Biophysica Acta 924, 408419.CrossRefGoogle ScholarPubMed
Willson, R. L. (1987). Vitamin E, selenium, zinc and copper interactions in free radical protection against illplaced iron. Proceedings of the Nutrition Society 46, 2734.CrossRefGoogle Scholar
Wilson, R. B., Middleton, C. C. & Sun, G. Y. (1978). Vitamin E, antioxidants and lipid peroxidation in experimental atherosclerosis of rabbits. Journal of Nutrition 108, 18581867.CrossRefGoogle ScholarPubMed
Yagi, K. (1987). Lipid peroxides and human diseases. Chemistry and Physics of Lipids 45, 337351.CrossRefGoogle ScholarPubMed
Yang, G., Chen, J., Wen, Z., Ge, K., Zhu, L., Chen, X. & Chen, X. (1984). The role of selenium in Keshan Disease. Advances in Nutrition Research 6, 203231.CrossRefGoogle ScholarPubMed
Ziegler, R. G. (1989). A review of epidemiologic evidence that carotenoids reduce the risk of cancer. Journal of Nutrition 119, 116122.CrossRefGoogle ScholarPubMed
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