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Effects of betaine on non-alcoholic liver disease

Published online by Cambridge University Press:  05 April 2021

Weiqiang Chen
Guangzhou Kingmed Diagnostics Group Co., Ltd., Guangzhou, 510320, China Key Laboratory of Prevention and treatment of cardiovascular and cerebrovascular diseases, Ministry of Education, Gannan Medical University, Ganzhou, 341000, China
Minjuan Xu
Department of Obstetrics and Gynecology, Ganzhou People’s Hospital, Ganzhou, 341000, China
Minwen Xu
First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China
Yucai Wang
First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China
Qingyan Zou
First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China
Shuixiang Xie*
Key Laboratory of Prevention and treatment of cardiovascular and cerebrovascular diseases, Ministry of Education, Gannan Medical University, Ganzhou, 341000, China
Liefeng Wang*
Key Laboratory of Prevention and treatment of cardiovascular and cerebrovascular diseases, Ministry of Education, Gannan Medical University, Ganzhou, 341000, China
*Correspondence authors: Shuixiang Xie, email and Liefeng Wang
*Correspondence authors: Shuixiang Xie, email and Liefeng Wang


The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) poses a growing challenge in terms of its prevention and treatment. The ‘multiple hits’ hypothesis of multiple insults, such as dietary fat intake, de novo lipogenesis, insulin resistance, oxidative stress, mitochondrial dysfunction, gut dysbiosis and hepatic inflammation, can provide a more accurate explanation of the pathogenesis of NAFLD. Betaine plays important roles in regulating the genes associated with NAFLD through anti-inflammatory effects, increased free fatty oxidation, anti-lipogenic effects and improved insulin resistance and mitochondrial function; however, the mechanism of betaine remains elusive.

Review Article
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society

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These authors contributed equally to this work.


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