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Using Indentation and Intra-Vascular Ultrasound to Measure Arterial Response

Published online by Cambridge University Press:  15 March 2011

P.M. Anderson ,
E.N. Glaser ,
A.I. Veress ,
G.M. Pharr ,
D.G. Vince ,
J.F. Cornhill  and
E.E. Herderick
P.M. Anderson
Affiliation:
Materials Science and Engineering, Ohio State University, 2041 College Rd., Columbus, OH 43210-1179, anderson.1@osu.edu
E.N. Glaser
Affiliation:
Biomedical Engineering, Ohio State University, Columbus, OH 43210-1002
A.I. Veress
Affiliation:
Medical Imaging Research Lab, University of Utah, Salt Lake City, UT 84108-1218
G.M. Pharr
Affiliation:
Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831-6116
D.G. Vince
Affiliation:
Biomedical Engineering, The Cleveland Clinic, Cleveland, OH 44195-0001
J.F. Cornhill
Affiliation:
Biomedical Engineering, The Cleveland Clinic, Cleveland, OH 44195-0001
E.E. Herderick
Affiliation:
Biomedical Engineering, Ohio State University, Columbus, OH 43210-1002
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Abstract

Two alternatives to standard tensile testing of arteries are discussed. The first involves inflation of arteries and simultaneous measurement of radial displacement with intra-vascular ultrasound (IVUS). The second involves the measurement of load versus displacement during micro-indentation of the intimal surface. The IVUS technique is used to study the nonlinear stiffening of porcine coronaries during inflation and, ultimately, it may provide a method to determine mechanical properties in vivo. Processing of the IVUS data relies on accurate determination of the luminal/intimal and medial/advential boundaries during inflation. The microindentation technique is used to study the effect of loading rate on tissue stiffness, recovery, and internal dissipation. Ultimately, this technique may provide a method to measure local mechanical properties in the vicinity of an atherosclerotic plaque, for example. Accurate determination of the initial contact point between the indenter and intima is required, however. The techniques appear to successfully capture significant, nonlinear, time-dependent properties of arterial tissue.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 662: Symposia LL/MM/NN/OO – Biomaterials for Drug Delivery & Tissue Engineering , 2000 , MM2.4
Copyright
Copyright © Materials Research Society 2001

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