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Theranostic Anticancer Agents Based on Internally Functionalized ORMOSIL Nanoparticles

Published online by Cambridge University Press:  17 February 2014

Nathan I. Walton ,
Zhe Gao  and
Ilya Zharov
Nathan I. Walton
Affiliation:
Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA
Zhe Gao
Affiliation:
Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA
Ilya Zharov
Affiliation:
Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA
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Abstract

We prepared organically modified silica (ORMOSIL) nanoparticles with internal functional groups and mesoporosity, suitable for the incorporation of modalities for both MRI imaging and cancer treatment by neutron capture therapy using gadolinium-157 nuclei. These modalities were incorporated by preparing ORMOSIL nanoparticles with reactive functional groups throughout the nanoparticle body, followed by their conversion into the metal chelating moieties inside the nanoparticles.

Keywords

nanostructurebiomedicalsol-gel
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1625: Symposium I – Multiscale Materials in the Study and Treatment of Cancer , 2014 , mrsf13-1625-i06-03
Copyright
Copyright © Materials Research Society 2014 

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References

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