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A Study of the Mass Transport Resistance of Glucose Across Rat Capsular Membranes

Published online by Cambridge University Press:  26 February 2011

C. L. Freeman ,
K. G. Mayhan ,
G. J. Picha  and
C. K. Colton
C. L. Freeman
Affiliation:
Baxter Healthcare Corporation, Technology & Ventures Division, Irvine CA 92715
K. G. Mayhan
Affiliation:
Baxter Healthcare Corporation, Technology & Ventures Division, Irvine CA 92715
G. J. Picha
Affiliation:
Cleveland Metropolitan General Hospital, Division of Plastic Surgery, Cleveland, OH 44179
C. K. Colton
Affiliation:
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
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Extract

The interaction between a polymer or other foreign surface and soft tissue is determined by a variety of materials and tissue factors. After failing to engulf the foreign body, the classical response is to wall it off. First the site is invaded by macrophages and giant cells and then fibrous connective tissue is laid down. This fibrous connective tissue gradually replaces the cellular matrix and forms the capsule. The composition is mostly collagen and mucopolysaccharides with few cells in the mature capsule. It contains 75–80% water.

When the implant surface represents a sensor and the transport of low molecular weight species across the capsule is necessary for meaningful measurement and response time, the mass transport resistance of the capsule may become a critical factor. This study represents an initial attempt to characterize the diffusion of glucose through fibrous capsules grown around silicone elastomer implants in a rat. Specifically, the study was designed to develop techniques to measure mass transport properties of tissue capsules, to use these techniques to determine effective glucose transport properties at two weeks, four weeks, and ten weeks after implant; and, to use these results along with histological examinations to gain an understanding of the factors which influence mass transport.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 773
Copyright
Copyright © Materials Research Society 1988

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