Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-17T21:31:18.406Z Has data issue: false hasContentIssue false
  • English
  • Français

Specific Interaction of Influenza Virus with Organized Assemblies of Polydiacetylenes

Published online by Cambridge University Press:  15 February 2011

Deborah H. Charych ,
Wayne Spevak ,
Jon O. Nagy  and
Mark D. Bednarski
Deborah H. Charych
Affiliation:
The Center for Advanced Materials, Lawrence Berkeley Laboratory, Berkeley, California 94720
Wayne Spevak
Affiliation:
The Center for Advanced Materials, Lawrence Berkeley Laboratory, Berkeley, California 94720
Jon O. Nagy
Affiliation:
The Center for Advanced Materials, Lawrence Berkeley Laboratory, Berkeley, California 94720
Mark D. Bednarski
Affiliation:
The Center for Advanced Materials, Lawrence Berkeley Laboratory, Berkeley, California 94720
Get access

Abstract

Supramolecular organizates of liposomes and Langmuir-Blodgett (LB) films are described which are capable of specifically binding to pathogens such as influenza virus. The specific interaction is between the hemagglutinin protein of the virus and an α-C-glycoside of sialic acid expressed on the surface of the liposome or LB film. Sialic acidcontaining liposomes were found to inhibit influenza virus infectivity in cell culture, and may provide a basis for new materials which act as therapeutic agents. Sialic acid-containing LB films also specifically bind to the influenza virus. In this case, the conjugated polymer backbone acts as a built-in reporter of the binding event, measurable by a chromatic change in the visible absorption spectrum. These films may provide a basis for new materials which act as direct detectors of binding

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 292: Symposium S – Biomolecular Materials , 1992 , 153
Copyright
Copyright © Materials Research Society 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Albrecht, O., Johnston, D.S., Villaverde, C., and Chapman, D., Biochim. Biophys. Acta 687, 165 (1982).Google Scholar
2. Bader, H. and Ringsdorf, H., J. Poly. Sci., Polymer Chemistry Edition 20, 1623 (1982).Google Scholar
3. Bader, H., Wagenen, R. Van, Andrade, J.D., and Ringsdorf, H., J. Colloid and Interface Science 101, 246 (1984).Google Scholar
4. Paulson, J.C., in The Receptors, edited by Conn, M., (Academic Press, New York, 1985), v. 2, pp. 131–219.Google Scholar
5. Wiley, D.C. and Skehel, J.J., Annu. Rev. Biochem. 56, 365 (1987).Google Scholar
6. Matlin, K.S., Reggio, H., Helenius, A., and Simons, K., J. Cell Biology 91, 601 (1981).Google Scholar
7. New, R.R., in Liposomes, A Practical Approach, edited by New, R.R., (Oxford University Press, Oxford, 1990) pp. 33–104.Google Scholar
8. Rogers, G.N., Pritchett, T.J., Lane, J.L., and Paulson, J.C., Virology 131, 394 (1983).Google Scholar
9. Barrett, T. and Inglis, S.C. in Virology, A Practical Approach, edited by Mahy, B.W.J., (Oxford University Press, Oxford, 1985) pp. 123.Google Scholar
10. Spaltenstein, A. and Whitesides, G.M., J. Am. Chem. Soc. 113, 686 (1991).Google Scholar
11. Matrosovich, M.N., Mochalova, L.V., Marinina, V.P., Byramova, N.E., and Bovin, N.V., FEBS Lett. 272, 209 (1990).Google Scholar
12. Nagy, J.O., Wang, P., Gilbert, J.H., Schaefer, M., Hill, T.G., Callstrom, M.R., and Bednarski, M.D., J. Med. Chem. (1992, in press).Google Scholar
13. Jencks, W.P., Proc. Natl. Acad. Sci., USA 78, 4046 (1981).Google Scholar
14. Sauter, N.K., Bednarski, M.D., Wurzburg, B.A., Hanson, J.E., Whitesides, G.M., and Wiley, D.C., Biochemistry, 28, 8388 (1989).Google Scholar
15. Nagy, J.O. and Bednarski, M.D., Tetrahedron Lett. 32, 3953 (1991).Google Scholar
16. Spevak, W., Nagy, J.O., Charych, D.H., Schaefer, M.E., Gilbert, J.H., and Bednarski, M.D., J. Am. Chem. Soc. (1992, in press).Google Scholar
17. Tieke, B., Graf, H.J., Wegner, G., Naegele, B., Ringsdorf, H., Banerjie, A., Day, D., and Lando, J.B., Colloid and Polymer Sci. 255, 521 (1977).Google Scholar
18. Day, D. and Ringsdorf, H., J. Polymer Sci. Polymer Letters Edition 16, 205 (1978).Google Scholar
19. Lopez, E., O'Brien, D.F., and Whitesides, T.H., J. Am. Chem. Soc. 104, 305 (1982).Google Scholar
20. Chu, B. and Xu, R., Acc. Chem. Res. 24, 384 (1991).Google Scholar
21. Wenzel, M. and Atkinson, G.H., J. Am. Chem. Soc. 111, 6123 (1989).Google Scholar
22. Mino, N., Tamura, H., and Ogawa, K., Langmuir 7, 2336 (1991).Google Scholar
23. Row, J.N., Pharmaceutical Research 9, 835 (1992).Google Scholar