Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-18T00:34:10.492Z Has data issue: false hasContentIssue false
  • English
  • Français

Plasma graft polymerization of Acrylic Acid and immobilization of Heparin to improve blood compatibility of Polyethylene terephthalate (PET).

Published online by Cambridge University Press:  11 July 2012

Samin Eftekhari  and
Hamid Mirzadeh
Samin Eftekhari
Affiliation:
Department of Chemical Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario, Canada, M5B 2K3, Fax: 416-979-5153
Hamid Mirzadeh
Affiliation:
Polymer Science Engineering Department, Amirkabir University of Technology, 424 Hafez-Ave.,15875-4413, Tehran, Iran
Get access

Abstract

Polymeric materials have been attracted the attention of researchers in various R&D applications. In this research, attempts were made to evaluate the changes in blood compatibility of polyethylene terephthalate (PET) by grafting acrylic acid (AAc) and immobilizing heparin by employing two-step plasma treatment. The PET surface was modified by using a novel method named “two-step plasma treatments” (TSPT). While first plasma is creating active sites for grafting, the second plasma polymerizing pre-adsorbed reactive monomer onto the surface of films. Finally, heparin immobilization was performed in the presence of 1-ethyl-3-(dimethylaminopropyl) carbodiimide. All films were characterized by attenuated total reflection Fourier transformed infrared (ATR-FTIR) spectroscopy and scanning electron microscopy (SEM). The surface hydrophilicity of films was studied by water contact angle test and blood compatibility evaluated by Lactate dehydrogenase method (LDH Test). In vitro studies based on LDH results demonstrared that platelet adhesion onto the modified surfaces with heparin was drastically reduced in comparison with unmodified PET.

Keywords

biomaterialscanning electron microscopy (SEM)polymerization
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1469: Symposium WW – Plasma Processing and Diagnostics for Life Sciences , 2012 , mrss12-1469-ww08-07
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Mirzadeh, H., Khorasani, M., Sammes, P., J. Iran.Polym. 7, 5(1998).Google Scholar
2. Mirzadeh, H., Dadsetan, M., J. Rad. Phy.Chem. 67, 381 (2003).Google Scholar
3. Lu, HW., Lu, H., Chen, W., J. Mat. Letters. 58, 29(2003).10.1016/S0167-577X(03)00408-7Google Scholar
4. Mirzadeh, H., Bagher, Sh.. Phy. & Chem. 76, 1435 (2007).Google Scholar
5. Mirzadeh, H., Karkhaneh, A., J. App. Poly. Sci. 105, 2208(2007).Google Scholar
6. Morrison, Rt., Boyd, Rn.. Organic Chemistry book. Allyn & Bacon, Inc. Boston, (1987).Google Scholar
7. Riccardi, C., Esena, P., Zanini, S., Tontini, M., Poletti, G., Orsini, F., J. Surf. Coat. Tech. 200,664(2005).Google Scholar
8. Yoshida, W., Faibish, Rs., Cohen, Y., J. Col. Inter. Sci. 256,341(2002).Google Scholar
9. Fujimoto, K., Tadokoro, H., Ueda, Y., Ikada, Y., J. Biomat. 14,442(1993).10.1016/0142-9612(93)90147-TGoogle Scholar
10. Wang, Xh., Li, Dp., Wang, Wj., Feng, Ql., J. Bio. Macromol. 33, 95(2003).10.1016/S0141-8130(03)00072-2Google Scholar
11. Hou, C., Yuan, Q., Huo, D., Zheng, Sh., Zhan, D., J. Bio. Mat. Res. 847(2007).Google Scholar