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Near Infrared Tunable Gold Nanoparticles for Low Power Laser Ablation of Esophageal Adenocarcinoma

Published online by Cambridge University Press:  30 March 2012

Guandong Zhang ,
Jacek Jasinski ,
Dhruvinkumar Patel ,
Kurtis James ,
Xinghua Sun  and
Andre M. Gobin
Guandong Zhang
Affiliation:
Bioengineering Department, J. B. Speed School of Engineering, University of Louisville, KY, 40292, USA.
Jacek Jasinski
Affiliation:
Conn Center for Renewable Energy Research, J. B. Speed School of Engineering, University of Louisville, KY 40292, USA.
Dhruvinkumar Patel
Affiliation:
Bioengineering Department, J. B. Speed School of Engineering, University of Louisville, KY, 40292, USA.
Kurtis James
Affiliation:
Bioengineering Department, J. B. Speed School of Engineering, University of Louisville, KY, 40292, USA.
Xinghua Sun
Affiliation:
Bioengineering Department, J. B. Speed School of Engineering, University of Louisville, KY, 40292, USA.
Andre M. Gobin
Affiliation:
Bioengineering Department, J. B. Speed School of Engineering, University of Louisville, KY, 40292, USA.
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Abstract

Gold nanoparticles (GNPs) with precisely controlled near infrared (NIR) absorption were synthesized by one-step reaction of chloroauric acid and sodium thiosulfate. The NIR absorption wavelengths and average particle size increase with increasing molar ratio of HAuCl4/Na2S2O3. The as-synthesized GNPs consist of different shape and size, including small spherical gold colloids and larger non-spherical gold crystals. The GNPs with good chemical and optical stability only form in a suitable range of the HAuCl4/Na2S2O3 molar ratio. High molar ratio of HAuCl4/Na2S2O3 reduces GNPs stability due to Ostwald ripening. Chitosan coating improves particle stability and allows these GNPs effective ablation for esophageal adenocarcinoma under low power NIR laser radiation.

Keywords

Aulaser ablationnanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1416: Symposium JJ – Nanofunctional Materials, Nanostructures and Nanodevices for Cancer Applications , 2012 , mrsf11-1416-jj03-10
Copyright
Copyright © Materials Research Society 2012

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References

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