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Ion Conductance of Cylindrical Solid State Nanopores Used in Coulter Counting Experiments

Published online by Cambridge University Press:  01 February 2011

Leo Petrossian ,
Seth J Wilk ,
Punarvasu Joshi ,
Michael Goryll ,
Jonathan D Posner ,
Stephen M Goodnick  and
Trevor J Thornton
Leo Petrossian
Affiliation:
havage@gmail.com, Arizona State University, Electrical Engineering, Tempe, AZ, 85287, United States
Seth J Wilk
Affiliation:
Seth.Wilk@asu.edu, Arizona State University, Electrical Engineering, Tempe, AZ, 85287, United States
Punarvasu Joshi
Affiliation:
punarvasu@asu.edu, Arizona State University, Electrical Engineering, Tempe, AZ, 85287, United States
Michael Goryll
Affiliation:
Michael.Goryll@asu.edu, Arizona State University, Electrical Engineering, 551 E Tyler Mall, Tempe, AZ, 85287, United States, 480-965-9517, 480-965-8118
Jonathan D Posner
Affiliation:
Jonathan.Posner@asu.edu, Arizona State University, Mechanical and Aerospace Engineering, Tempe, AZ, 85287, United States
Stephen M Goodnick
Affiliation:
Stephen.Goodnick@asu.edu, Arizona State University, Electrical Engineering, Tempe, AZ, 85287, United States
Trevor J Thornton
Affiliation:
Trevor.Thornton@asu.edu, Arizona State University, Electrical Engineering, Tempe, AZ, 85287, United States
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Abstract

Nanoscale apertures that provide a fluidic path between two reservoirs can be used for numerous applications. These applications include patch-clamp type measurements, Coulter counting and molecular studies. For Coulter counting of nanometer-sized analytes, we have developed a process capable of reproducibly fabricating cylindrical apertures in a silicon-on-insulator substrate with diameters less than 30 nm. The fabrication process utilizes electron beam lithography for the lithographic definition of the apertures enabling accurate control of final device dimensions. Measurements of the conductance of the pores as a function of KCl concentration reveal the presence of a surface conduction mechanism that dominates the conductance of the nanopore and leads to a deviation of the concentration dependence of the conductance from the case of bulk solution. From current traces recorded, the passage of individual particles through the pore can be concluded.

Keywords

nanostructurelithography (removal)ion-solid interactions
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1092: Symposium BB – Signal Transduction Across the Biology-Technology Interface , 2008 , 1092-BB02-09
Copyright
Copyright © Materials Research Society 2008

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References

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