Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-19T12:03:22.410Z Has data issue: false hasContentIssue false
  • English
  • Français

Hydroxyapatite Pickering PolyHIPEs And “Thermo”HIPEs As Injectable Scaffolds For Tissue Engineering

Published online by Cambridge University Press:  19 March 2012

Shengzhong Zhou ,
Alexander Bismarck  and
Joachim H.G. Steinke
Shengzhong Zhou
Affiliation:
Department of Chemical Engineering, Polymer and Composite Engineering (PaCE) Group, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K. Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK. e-mail: j.steinke@imperial.ac.uk
Alexander Bismarck
Affiliation:
Department of Chemical Engineering, Polymer and Composite Engineering (PaCE) Group, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K.
Joachim H.G. Steinke
Affiliation:
Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK. e-mail: j.steinke@imperial.ac.uk
Get access

Abstract

Two types of porous materials derived from emulsion templates are described as potential scaffolds for tissue engineering. Novel oil-in-water particle stabilised, Pickering High Internal Phase Emulsions (HIPE) stabilised with hydroxyapatite (HAp) nanoparticles were prepared and polymerised to form stable polyHIPEs. By adding a water soluble glycidyl methacrylate (GMA) derivatised dextran as monomer to the continuous aqueous phase of the HIPEs, these Pickering-HIPEs stabilised by nontoxic biocompatible HAp nanoparticles, can be used as templates to manufacture interconnected high porosity macroporous hydrogels. A second type of emulsion templated “poly”HIPE was prepared without the need for covalent crosslinking chemistry which was replaced by a thermally-induced non-covalent scaffold forming process (thermoHIPE). These scaffolds form close to body temperature and potentially offer a new approach to the formation of injectable scaffolds for tissue engineering.

Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1376: Symposium S11 – Biomaterials for Medical Applications , 2012 , imrc11-1376-s11-o8
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Kimmins, S. D. and Cameron, N. R., Adv. Funct. Mater. 21, 211 (2011).Google Scholar
2. Zhang, H., Cooper, A. I., Adv. Mater. 19, 2439 (2007).Google Scholar
3. Krajnc, P., Stefanec, D., Pulko, I., Macromolecular Rapid Commun. 26, 1289 (2005).Google Scholar
4. Zhang, H., Cooper, A. I., Soft Matter, 1, 107 (2005).Google Scholar
5. Ravikrishna, R., Green, R., Valsaraj, K. T., J. Sol-Gel Sci. Technol. 34, 111 (2005).Google Scholar
6. Barbetta, A., Massimi, M., Devirgiliis, L. C., Dentini, M., Biomacromolecules 7, 3059 (2006).Google Scholar
7. van Dijk-Wolthuis, W. N. E., Franssen, O., Talsma, H., van Steenbergen, M. J., Kettenes-van den Bosch, J. J., Hennink, W. E., Macromolecules 28, 6317 (1995).Google Scholar
8. Binks, B. P., Cur. Opin. Coll. & Interf. Sci. 7, 21 (2002).Google Scholar
9. Cai, Y., Liu, Y., Yan, W., Hu, Q., Tao, J., Zhang, M., Shi, Z., Tang, R., J. Mater. Chem. 17, 3780 (2007).Google Scholar
10. Cameron, N. R., Polymer 46, 1439 (2005).Google Scholar
11. Ikem, V. O., Menner, A., Bismarck, A., Angew. Chem. Int. Ed. 47, 8277 (2008).Google Scholar