Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-18T00:30:08.504Z Has data issue: false hasContentIssue false
  • English
  • Français

Fast Formation of Biomimetic Ca-P Coatings on Ti6Al4V

Published online by Cambridge University Press:  10 February 2011

F. Barrère ,
P. Layrolle ,
C. A. van Blitterswijk  and
K. de Groot
F. Barrère
Affiliation:
IsoTis BV, Prof. Bronkhostlaan 10, 3723 MB Bilthoven, The Netherlands Twente University, The Netherlands
P. Layrolle
Affiliation:
IsoTis BV, Prof. Bronkhostlaan 10, 3723 MB Bilthoven, The Netherlands
C. A. van Blitterswijk
Affiliation:
IsoTis BV, Prof. Bronkhostlaan 10, 3723 MB Bilthoven, The Netherlands Twente University, The Netherlands
K. de Groot
Affiliation:
IsoTis BV, Prof. Bronkhostlaan 10, 3723 MB Bilthoven, The Netherlands Leiden University, The Netherlands
Get access

Abstract

The aim of this study was to accelerate the formation of biomimetic Calcium-Phosphate (Ca-P) coatings on Ti6Al4V by using a 5 times more concentrated Simulated Body Fluid (SBFx5) than the regular SBF. The production of SBFx5 was possible by decreasing the pH of the solution to approximately 6 with CO2 gas. The release of this mildly acidic gas allowed the formation of a Ca-P film after 4h of immersion at pH=6.8. The structure of this coating was an amorphous carbonated Ca-P. In addition, our experiments showed that the presence of Mg2+ was absolutely necessary for the Ca-P coating formation on Ti6Al4V substrate. Mg2+ is a crystal growth inhibitor and favored the heterogeneous nucleation. Furthermore, depth profile X-Ray Photoelectron Spectroscopy showed that Ca-P nucleation on the passive Titanium oxide (TiO2) passive layer was initiated by Ca2+ and Mg2+. The attachment of this Ca-P coating resulted probably from chemical bonds such as P-O-Ti and Ca-O-Ti. Ca was more present at the coating/substrate interface than P. Thereby Ca-O-Ti seems to be favored.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 599: Symposium DD – Mineralization in Natural & Synthetic Biomaterials , 1999 , 135
Copyright
Copyright © Materials Research Society 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

[1] Kokubo, T., Kushitani, H., Sakka, S., Kitsugi, T. and Yamamuro, T., J. Biomed Mater. Res. 24, 1990, pp721–734 Google Scholar
[2] Li, P., Kangasniemi, I., Groot, K. de and Kokubo, T., J. Am. Ceram. Soc. 77, 1994, pp1307–1312 Google Scholar
[3] Peltola, T., Pätsi, M., Rahiala, H., Kangasniemi, I. and Yli-Urpo, A., J. Biomed Mater. Res. 41, 1998, pp504–510 Google Scholar
[4] Kim, H.M., Miyaji, F., Kokubo, T. and Nakamura, T., J Biomed. Mater. Res. 32, 1996, pp409–417 Google Scholar
[5] Wen, H.B., PhD thesis, Leiden Universiteit, 1998 Google Scholar
[6] Combes, C., Rey, C. and Frèche, M., Colloids and surfaces B: Biointerfaces 11, 1998, pp15–27 Google Scholar
[7] Li, P. and Groot, K. de, J Biomed Mater. Res. 27, 1993, pp 129–138 Google Scholar
[8] Healy, K.E. and Ducheyne, P., Biomed, J. Mater. Res. 26, 1992, pp319–338 Google Scholar
[9] Royer, P., PhD thesis, INP Toulouse, 1993, p52 Google Scholar
[10] Lebugle, A., Sallek, B. and Tai, A. Tai, J. Mater. Chem. 9, 1999, pp2511–2515 Google Scholar
[11] Layrolle, P. and Lebugle, A., Chem Mater. 8, 1996, pp 134–144 Google Scholar
[12] Tomazic, B., Tomson, M. and Nancollas, G.H., Archs. Oral Biol. 20, 1975, pp 803–808 Google Scholar
[13] Boskey, A.L. and Posner, A.S., Mat. Res. Bull. 9, 1974, pp907–916 Google Scholar
[14] Thull, R., in Metals as biometarials, edited by Helsen, J.A. and Breme, H.J. (Wiley England 1998), pp 291–315 Google Scholar
[15] Tengvall, P. and Lundstrdm, I., Clin. Mater. 9, 1992, pp115–134 Google Scholar
[16] Bachara, B.N. and Fisher, H.R.A., Calc. Tiss. Res. 3, 1969, pp 348–357 Google Scholar