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Culture of Mammalian Cells on Single Crystal SiC Substrates

Published online by Cambridge University Press:  01 February 2011

Camilla Coletti ,
Mark J. Jaroszeski ,
Andrew M. Hoff  and
Stephen E. Saddow
Camilla Coletti
Affiliation:
camilla@eng.usf.edu, University of South Florida, Electrical Engineering, 4202 E. Fowler Ave., Tampa, FL, 33620, United States
Mark J. Jaroszeski
Affiliation:
mjarosze@eng.usf.edu, University of South Florida, Chemical Engineering, 4202 E. Fowler Ave., Tampa, FL, 33620, United States
Andrew M. Hoff
Affiliation:
hoff@eng.usf.edu, University of South Florida, Electrical Engineering, 4202 E. Fowler Ave., Tampa, FL, 33620, United States
Stephen E. Saddow
Affiliation:
saddow@eng.usf.edu, University of South Florida, Electrical Engineering, 4202 E. Fowler Ave., Tampa, FL, 33620, United States
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Abstract

Crystalline silicon carbide (SiC) has the potential to become an important biomaterial and a versatile interface between the electronic and biological world. In this work, single crystal SiC biocompatibility is investigated by culturing mammalian cells directly on SiC substrates. The cell morphology and the quality of the cell adhesion have been studied using fluorescence microscopy, while MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays have been performed to quantify cell viability and number. Standard culture-wells and silicon (Si) substrates were used as controls in the final assessment of crystalline SiC biocompatibility.

Keywords

biomaterialsemiconductingcrystalline
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 950: Symposium D – Biosurfaces and Biointerfaces , 2006 , 0950-D04-22
Copyright
Copyright © Materials Research Society 2007

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References

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