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Stable Colloids of Paclitaxel Nanoparticles Coated with PEGylated Polyelectrolyte Shells

Published online by Cambridge University Press:  07 March 2012

Tatsiana G. Shutava
Affiliation:
Institute for Micromanufacturing, Louisiana Tech University, 911 Hergot Ave., Ruston, LA 71272, U.S.A.
Kirill A. Arapov
Affiliation:
Institute for Micromanufacturing, Louisiana Tech University, 911 Hergot Ave., Ruston, LA 71272, U.S.A.
Pravin P. Pattekari
Affiliation:
Institute for Micromanufacturing, Louisiana Tech University, 911 Hergot Ave., Ruston, LA 71272, U.S.A.
Yuri M. Lvov
Affiliation:
Institute for Micromanufacturing, Louisiana Tech University, 911 Hergot Ave., Ruston, LA 71272, U.S.A.
Tatyana S. Levchenko
Affiliation:
Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Ave., Boston, MA 02115, U.S.A.
Rupa R. Sawant
Affiliation:
Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Ave., Boston, MA 02115, U.S.A.
Vladimir P. Torchilin
Affiliation:
Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Ave., Boston, MA 02115, U.S.A.
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Abstract

A novel nanoparticulated form of the poorly water-soluble anticancer drug paclitaxel (PTX) suitable for intravenous administration has been developed using sonication-assisted layer-by-layer (LbL) assembly. The nanoparticles contain up to 70 wt.% of the drug and consist of 150-180 nm solid crystal paclitaxel cores coated with 20-30 nm thick shells of alternative layers of PEGylated poly-L-lysine and heparin. Dispersions of PTX nanoparticles are stable in different biological solvents at concentrations up to 5 mg/ml. Intravenous administration of the LbL-coated nano-crystalline PTX to mice via tail injection provided the preliminary confirmation of their safety and tolerability.

Type
Research Article
Copyright
Copyright © Materials Research Society 2012

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