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Perspective of strategic plasma therapy for prognostic improvement of patients with ovarian cancer

Published online by Cambridge University Press:  28 November 2013

Hiroaki Kajiyama
Affiliation:
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan.
Fumi Utsumi
Affiliation:
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan.
Kae Nakamura
Affiliation:
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan.
Hiromasa Tanaka
Affiliation:
Department of Electrical Engineering and Computer Science, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
Masaru Hori
Affiliation:
Department of Electrical Engineering and Computer Science, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
Fumitaka Kikkawa
Affiliation:
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan.
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Abstract

Epithelial ovarian carcinoma (EOC) is the leading cause of cancer-related death in women in Western countries. Once patients experience recurrence, complete cure is almost impossible. We elucidated the effect of nonequilibrium atmospheric pressure plasma on the growth of EOC, particularly in plasma-activated medium (PAM). Furthermore, we examined the role of reactive oxygen species (ROS) or their scavengers in chronic antineoplastic-resistant EOC cells. As a result, we showed PAM induced the antitumor effect of EOC cells in vitro and in vivo, even in chemoresistant cells. To apply the plasma treatment for advanced or recurrent EOC, we suggest adopting indirect plasma therapy instead of direct plasma considering intraperitoneal administration in the future. However, there are several problems under investigation, including intracellular mechanism of antitumor effect by PAM and adverse event in vivo.

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Copyright
Copyright © Materials Research Society 2013 

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References

Teoh, D, et al. . Int J of Gynecol Cancer 22: 348359 (2012).CrossRef
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Fridman, G, et al. . Plasma Chemistry and Plasma Processing 26: 425442 (2006).CrossRef
Lee, JK, et al. . Jpn J Appl Phys 50 (2011).
Kajiyama, H, et al. . Int J Oncol 31: 277283 (2007).
Maeda, O, et al. . Int J Cancer 130: 113121 (2012).CrossRef
Iseki, S, et al. . Applied Physics Letters 100 (2012).CrossRef

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