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In-Vivo Assessment of Tissue Compatibility and Calcification of Bulk and Porous Silicon

Published online by Cambridge University Press:  09 August 2011

A P Bowditch
Affiliation:
Biomedical Sciences Dept, CBD, DERA Porton Down, Wiltshire, SP4 OJQ.
K Waters
Affiliation:
Biomedical Sciences Dept, CBD, DERA Porton Down, Wiltshire, SP4 OJQ.
H Gale
Affiliation:
Biomedical Sciences Dept, CBD, DERA Porton Down, Wiltshire, SP4 OJQ.
P Rice
Affiliation:
Biomedical Sciences Dept, CBD, DERA Porton Down, Wiltshire, SP4 OJQ.
E A M Scott
Affiliation:
Biomedical Sciences Dept, CBD, DERA Porton Down, Wiltshire, SP4 OJQ.
L T Canham
Affiliation:
Electronics Sector, DERA Malvem, St Andrews Road, Malvern, Worcestershire, WR14 3PS
C L Reeves
Affiliation:
Electronics Sector, DERA Malvem, St Andrews Road, Malvern, Worcestershire, WR14 3PS
A Loni
Affiliation:
Electronics Sector, DERA Malvem, St Andrews Road, Malvern, Worcestershire, WR14 3PS
T I Cox.
Affiliation:
Electronics Sector, DERA Malvem, St Andrews Road, Malvern, Worcestershire, WR14 3PS
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Abstract

The compatibility of both bulk and porous silicon at the subcutaneous site has been assessed for the first time, following ISO standard procedures. The in-vivo responses to implantation were monitored in the guinea pig and histopathological reactions evaluated at 1, 4, 12 and 26 weeks. Attention is focused here on the histological assessment protocols used, and the results demonstrating in-vivo evidence for good tissue compatibility, and porous Si bioactivity with regards calcification.

Type
Research Article
Copyright
Copyright © Materials Research Society 1999

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References

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