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Fabrication of Complex Hydrogel Materials by Utilizing Microfluidics and Micromolding

Published online by Cambridge University Press:  30 March 2012

Masumi Yamada
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Sari Sugaya
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Aoi Kobayashi
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Ayaki Miyama
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Yoji Naganuma
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Emi Yamada
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Shunta Kakegawa
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Minoru Seki
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
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Abstract

Here, we present microfluidic methods to fabricate complex hydrogel structures for 3D tissue or organ-like cell structures in vitro. First, a microfluidic system to continuously synthesize chemically and physically anisotropic Ca–alginate hydrogel microfibers is proposed to enable the guidance of cell proliferation and differentiation. Next, the microfluidic preparation methods for yarn-ball-shape hydrogel particles and extremely-small hydrogel microspheres. Finally, a newly developed micro-molding and bonding method for hydrogel micro-patterned plates is reported.

Type
Research Article
Copyright
Copyright © Materials Research Society 2012

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References

[1]. Miyama, A., Yamada, M., Sugaya, S., and Seki, M., Proceedings of MicroTAS2011, edited by Landers, J. et al. ., (Seattle, WA, 2011) pp. 825827.Google Scholar
[2]. Sugaya, S., Yamada, M., and Seki, M., Proceedings of MicroTAS2011, edited by Landers, J. et al. ., (Seattle, WA, 2011) pp. 1820.Google Scholar
[3]. Yamada, E., Yamada, M., Iwase, M., Sugaya, S., and Seki, M., Proceedings of MicroTAS2011, edited by Landers, J. et al. ., (Seattle, WA, 2011) pp. 18341836.Google Scholar

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