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Drug Delivery Systems Based on Hydroxyapaptite-coated Poly(lactic-co-glycolic acid) Microspheres

Published online by Cambridge University Press:  01 February 2011

Qingguo Xu
Affiliation:
qingguo.xu@materials.ox.ac.uk, University of Oxford, Department of Materials, Parks Road, Oxford, OX1 3PH, United Kingdom, +44-1865-273714, +44-1865-273789
Jan T Czernuszka
Affiliation:
jan.czernuszka@materials.ox.ac.uk, University of Oxford, Department of Materials, Parks Road, Oxford, OX1 3PH, United Kingdom
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Abstract

Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6%. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3 - 6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterised by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and osteoconductivity from HA. Hence, it could have potential applications in delivering drugs to treat bone disorders or infections.

Type
Research Article
Copyright
Copyright © Materials Research Society 2008

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Drug Delivery Systems Based on Hydroxyapaptite-coated Poly(lactic-co-glycolic acid) Microspheres
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