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Design, Synthesis, and Characterization of Hydroxyapatite Particulates

Published online by Cambridge University Press:  15 March 2011

Chun-Wei Chen
Affiliation:
Department of Ceramic and Materials Engineering, Rutgers University, 607 Taylor Road, Piscataway NJ 08854
Kullaiah Byrappa
Affiliation:
Department of Ceramic and Materials Engineering, Rutgers University, 607 Taylor Road, Piscataway NJ 08854
Charles S. Oakes
Affiliation:
Department of Ceramic and Materials Engineering, Rutgers University, 607 Taylor Road, Piscataway NJ 08854
Wojciech Sushanek
Affiliation:
Department of Ceramic and Materials Engineering, Rutgers University, 607 Taylor Road, Piscataway NJ 08854
Richard E. Riman
Affiliation:
Department of Ceramic and Materials Engineering, Rutgers University, 607 Taylor Road, Piscataway NJ 08854
Mamoru Senna
Affiliation:
Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223, Japan
Kelly Brown
Affiliation:
Johnson & Johnson Corporation Biomaterials Center, Rt. 22 W, P. O. Box 151, Somerville, NJ 08876
Kevor S. TenHuisen
Affiliation:
Johnson & Johnson Corporation Biomaterials Center, Rt. 22 W, P. O. Box 151, Somerville, NJ 08876
Victor F. Janas
Affiliation:
Johnson & Johnson Corporation Biomaterials Center, Rt. 22 W, P. O. Box 151, Somerville, NJ 08876
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Abstract

New hydrothermal technology for the preparation of hydroxyapatite designer particulates has been developed. Phase diagrams were constructed for the pH dependent equilibrium between monetite and HA from 50 to 200°C. Thermodynamic calculations were completed using temperature dependent functions for the relevant solution phase and solid-liquid equilibria and solute species activity coefficients. Model accuracy was evaluated through experiment at 50, 100, and 200°C and pHs between 2.2 and 8.9. The thermodynamic calculations and experimental results are in good agreement. Stoichiometric, crystalline HA has also been prepared by heterogeneous reaction of Ca(OH)2 powder and aqueous (NH4)2HPO4 at room temperature using mechanochemical-hydrothermal methods. This method appears to have very good reproducibility in terms of crystallinity and chemical composition.

Type
Research Article
Copyright
Copyright © Materials Research Society 2001

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