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Density Fluctuation in Coulombic Colloid Dispersion: Self-Assembly of Lipid A-Phosphates

Published online by Cambridge University Press:  01 February 2011

Henrich H. Paradies
Affiliation:
Hparadies@aol.com, The University of Salford, Joule Physics Laboratory, Materials Research Institute, The Crescent, Salford, M5 4 WT, United Kingdom, +441612954286, +441612955575
Chester A. Faunce
Affiliation:
c.a.faunce@salford.ac.uk, The University of Salford, Joule Physics Laboratory, Materials Research Institute, The Crescent, Salford, M5 4WT, United Kingdom
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Abstract

Dilute electrostatically–Vstabilized aqueous solutions of hexa-acylated (C14) lipid A-diphosphate from Escherichia coli were prepared with low polydispersities in shape, size and charge. A high degree of ordering was exhibited for volume fractions between Φ ≅ 1.5 × 10−4 and 3.5 × 10−4. The structure factor S(Q) was strongly dependent on the particle number density, the nature of ions, e.g. Ca2+, Mg2+, K+, Na+ and H+, the effective colloidal charge (Z*), and the Debye screening length, k. The magnitude and position of the S(Q) peaks vary not only with counterions, e.g. Ca2+ or Mg2+, and concentration (nM to μM), but also with the order of their addition to the lipid A-dispersions. Different types of colloidal-crystal structures were obtained for Φ ≅ 3.5 × 10−4. The Ca2+ and K+ salts exhibited FCC type-lattices with a = 56.3 nm and 55.9 nm, whereas the Na+ and Mg2+ salts of lipid A-diphosphate formed BCC type-lattices with a = 41.5 nm and 45.5 nm, respectively.

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Research Article
Copyright
Copyright © Materials Research Society 2007

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Density Fluctuation in Coulombic Colloid Dispersion: Self-Assembly of Lipid A-Phosphates
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