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Combinatorial Compounding

Published online by Cambridge University Press:  26 February 2011

Nico Adams ,
Martin Moneke ,
Serguel Acikalin Guelmues ,
Dalil Chenouf ,
Matthias Rehahn  and
Ulrich S Schubert
Nico Adams
Affiliation:
n.adams@tue.nl, Eindhoven University of Technology, Laboratory of Macromolecular Chemistry and Nanoscience, P.O. Box 513, Eindhoven, N/A, 5600 MB, Netherlands, +31(0)402472125, +31(0)402474186
Martin Moneke
Affiliation:
MMoneke@dki.tu-darmstadt.de, Deutsches Kunststoff Institut, Germany
Serguel Acikalin Guelmues
Affiliation:
SGuelmues@dki.tu-darmstadt.de, Deutsches Kunststoff Institut, Germany
Dalil Chenouf
Affiliation:
DChenouf@dki.tu-darmstadt.de, Deutsches Kunststoff Institut, Germany
Matthias Rehahn
Affiliation:
MRehahn@dki.tu-darmstadt.de, Deutsches Kunststoff Institut, Germany
Ulrich S Schubert
Affiliation:
u.s.schubert@tue.nl, Eindhoven University of Technology, Laboratory of Macromolecular Chemistry and Nanoscience, Netherlands
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Abstract

The need for fast and low-cost processes for compound development is obvious when “bespoke” products are required in small quantities. In a typical development workflow, many experiments are needed for the systematic study of the effects of additives and their potential synergistic interactions. This is usually accomplished using the one-variable-at-a-time variational principle. However, if the complexity of the formulation is high, the number of experiments that needs to be conducted soon becomes prohibitive. Therefore, new, but potentially more effective additives are not easily introduced. To address this problem, the plastics processing industry is turning to the notion of combinatorics, which has been shown to accelerate R&D times both in the pharmaceutical industry as well as in other areas of materials science such as catalysis and polymer chemistry.

The contribution discusses the development of a combinatorial compounding line, consisting of a production-size twin screw extruder with four gravimetric feeding units for the addition of additives. Furthermore, the development of fast on-line and in-line analytics for compound characterization is discussed.

Keywords

combinatorial synthesisblendpolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 894: Symposium LL – Combinatorial Methods and Informatics in Materials Science , 2005 , 0894-LL09-03
Copyright
Copyright © Materials Research Society 2006

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References

REFERENCES

[1] Uddin, M. K., Khan, M. A. and Ali, K. M. I., J. Appl. Polym. Sci., 60, 887 (2005)Google Scholar
[2] Gaechter, R., Mueller, H. and Klemchuk., P. P. Plastics additives handbook: stabilizers, processing aids, plasticizers, fillers, reinforcements, colorants for thermoplastics, Hanser, Munich (1993)Google Scholar
[3] Murphy., J. The additives for pastics handbook, Elsevier Advanced Technology, Oxford (1996)Google Scholar
[4] Potyrailo, R., Wroczynski, R. J., Pickett, C. J. and Rubinsztajn, M., Macromol. Rapid Comm., 24, 123 (2003)Google Scholar
[5] Potyrailo, R. and Pickett, J. E., Rapid non-destructive screening methods for polymeric coatings and materials, US Patent 6552787 B1 (2003)Google Scholar
[6] Ton-That, M.-T., Perrin-Sarrazin, F., Cole, K. C., Bureau, M. N. and Denault, J., Polym.Eng. Sci., 44, 1212 (2004)Google Scholar
[7] Demir, H., Arkis, E., Balkoese, D. and Uelkue, S., Polym. Deg. Stab., 89, 478 (2005)Google Scholar
[8] Hoogenboom, R., Meier, M. A. R. and Schubert, U. S., Macromol. Rapid Commun., 24, 16 (2003)Google Scholar
[9] Jandeleit, B., Schaefer, D. J., Powers, T. S., Turner, H. W. and Weinberg, W. H., Angew.Chem. Int. Ed., 38, 2492 (1999)Google Scholar
[10] Gilman, J. W., Bourbigot, S., Shields, J. R., Nyden, M., Kashiwagi, T., Davis, R. D.,Vanderhart, D. L., Demory, W., Wilkie, C. A., Morgan, A. B., Harris, J. and Lyon, R. E., J. Mat. Sci., 38, 4451 (2003)Google Scholar
[11] Haubs, M., Reisinger, T. and Schneller, A., Verfahren und Vorrichtung zur kombinatorischen Herstellung von Mischungen sowie deren Verwendung, EP 1410841 (2004)Google Scholar
[12] Deutsches Institut fuer Normung, Packaging - Sacks made from thermoplastic flexible film - Tear propagation on edge folds, DIN EN ISO 11897 (2001)Google Scholar
[13] Deutsches Institut fuer Normung, Plastics-Determination of Tensile Properties-Part 3: Test Conditions for Films and Sheets, DIN EN ISO 527-3 (2003)Google Scholar
[14] Alig, I., Lellinger, D. and Wassum, K., Kunststoffe, 6, 53 (2003)Google Scholar
[15] Alig, I., Lellinger, D. and Wassum, K., Kunststoffe, 12, 62 (2003)Google Scholar
[16] Romero, I. Garcia and Pasch, H., e-Polymers, 42, 1 (2005)Google Scholar
[17] Pasch, H. and Kilz, P., Macrmol. Rapid Commun., 24, 104 (2003)Google Scholar
[18] Pasch, H. and Schrod, M., Macrmol. Rapid Commun., 25, 224 (2004)Google Scholar
[19] Pasch, H., GIT Labor-Fachzeitschrift, 25 (2004)Google Scholar
[20] Pasch, H., Bruell, A. and Cabrera, K., e-Polymers, 20, 1 (2005)Google Scholar
[21] Moneke, M. and Rehahn, M., Combinatorial compounding and high-throughput screening,ANTEC 2005, Boston (2005)Google Scholar
[22] Moneke, M., KunststoffTrends, 5, 40–41 (2004)Google Scholar
[23] Davis, R. D., Bur, A. J., McBearty, M., Lee, Y.-H., Gilman, J. W. and Start, P. R., Polymer, 45, 6487 (2004)Google Scholar
[24] Gilman, J. W., Maupin, P. H., Harris, R. H., Bellayer, S., Bur, A. J., Roth, S. C., Murariu, M.,Morgan, A. B. and Harris, J. D., PMSE Prepr., 90, 717 (2004)Google Scholar
[25] Gilman, J. W., Davis, R. D., Bellayer, S., Maupin, P. H., Raghavan, D., Langat, J. K., Bourbigot, S., Flambard, X., Fox, D. M., Trulove, P. C. and De Longh, H. C., PMSE Prepr.,92, 168 (2005)Google Scholar
[26] Gilman, J. W., Davis, R. D., Shields, J. R., Wentz, D., Brassell, L. D., Morgan, A. B., Lyon, R. E. and Zanetto, J. E., Development of high-throughput methods for polymer flammability property characterization, International SAMPE Symposium and Exhibition, (2004)Google Scholar
[27] Adams, N. and Schubert, U. S., J. Comb. Chem., 6, 12–23 (2004)Google Scholar
[28] Adams, N. and Schubert, U. S., Macromol. Rapid Comm., 25, 48–58 (2004)Google Scholar