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A living electrode construct for incorporation of cells into bionic devices

Published online by Cambridge University Press:  27 June 2017

Josef Goding ,
Aaron Gilmour ,
Ulises Aregueta Robles ,
Laura Poole-Warren ,
Nigel Lovell ,
Penny Martens  and
Rylie Green
Josef Goding
Affiliation:
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia Department of Bioengineering, Imperial College London, London, UK
Aaron Gilmour
Affiliation:
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
Ulises Aregueta Robles
Affiliation:
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
Laura Poole-Warren
Affiliation:
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
Nigel Lovell
Affiliation:
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
Penny Martens
Affiliation:
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
Rylie Green*
Affiliation:
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia Department of Bioengineering, Imperial College London, London, UK
*
Address all correspondence to Rylie Green at r.green@imperial.ac.uk
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Abstract

A living electrode construct that enables integration of cells within bionic devices has been developed. The layered construct uses a combination of non-degradable conductive hydrogel and degradable biosynthetic hydrogel to support cell encapsulation at device surfaces. In this study, the material system is designed and analyzed to understand the impact of the cell carrying component on electrode characteristics. The cell carrying layer is shown to provide a soft interface that supports extracellular matrix development within the electrode while not significantly reducing the charge transfer characteristics. The living layer was shown to degrade over 21 days with minimal swelling upon implantation.

Type
Biomaterials for 3D Cell Biology Research Letter
Information
MRS Communications , Volume 7 , Issue 3 , September 2017 , pp. 487 - 495
Copyright
Copyright © Materials Research Society 2017 

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