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Design, fabrication, and characterization of polycaprolactone (PCL)-TiO2-collagenase nanofiber mesh scaffolds by Forcespinning

Published online by Cambridge University Press:  07 February 2019

K. del Ángel-Sánchez ,
N.A. Ulloa-Castillo ,
Emmanuel Segura-Cárdenas ,
Oscar Martinez-Romero  and
Alex Elías-Zuñiga
K. del Ángel-Sánchez*
Affiliation:
Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Avenida Eugenio Garza Sada #2501 Sur, Monterrey, Nuevo León 64849, México
N.A. Ulloa-Castillo
Affiliation:
Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Avenida Eugenio Garza Sada #2501 Sur, Monterrey, Nuevo León 64849, México
Emmanuel Segura-Cárdenas
Affiliation:
Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Avenida Eugenio Garza Sada #2501 Sur, Monterrey, Nuevo León 64849, México
Oscar Martinez-Romero
Affiliation:
Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Avenida Eugenio Garza Sada #2501 Sur, Monterrey, Nuevo León 64849, México
Alex Elías-Zuñiga
Affiliation:
Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Avenida Eugenio Garza Sada #2501 Sur, Monterrey, Nuevo León 64849, México
*
Address all correspondence to K. del Ángel-Sánchez at kdelangel@tec.mx
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Abstract

We report on the design of polycaprolactone (PCL)-TiO2-collagenase mesh scaffolds by Forcespinning technique. The dependence of the degree of crystallinity in PCL caused by the incorporation of dopants (TiO2-collagenase) and the reduction of dimensionality (1D), during the nanofiber formation, were investigated by x-ray diffraction and differential scanning calorimetry. The tensile strength of the mesh scaffolds (randomly oriented) was determined using uniaxial testing equipment. The permeability was measured by contact angle obtaining an improvement in the hydrophobicity for the PCL-TiO2-collagenase mesh scaffolds. The results reported in this research are of great relevance for tissue engineering applications.

Type
Research Letters
Information
MRS Communications , Volume 9 , Issue 1 , March 2019 , pp. 390 - 397
Copyright
Copyright © Materials Research Society 2019 

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