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Functional Tissue Engineering Through Biofunctional Macromolecules and Surface Design

Published online by Cambridge University Press:  31 January 2011

Lorenzo Moroni
Affiliation:
Institute for Biomedical Technology and Technical Medicine, University of Twente, The Netherlands; e-mail L.Moroni@tnw.utwente.nl.
Pamela Habibovic
Affiliation:
Institute for Biomedical Technology and Technical Medicine, University of Twente, The Netherlands; e-mail P.Habibovic@tnw.utwente.nl.
David J. Mooney
Affiliation:
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; e-mail mooneyd@deas.harvard. edu.
Clemens A. van Blitterswijk
Affiliation:
Institute for Biomedical Technology and Technical Medicine, University of Twente, The Netherlands; e-mail C.A.vanBlitterswijk@tnw.utwente.nl.
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Abstract

Tissue engineering is a rapidly developing discipline that has already entered the clinics and will tremendously change patient management in the near future. The aim of classical tissue engineering is to heal damaged or diseased tissues and organs through the combination of cells, biological factors, and porous biomaterials. The resulting, engineered tissue must possess appropriate functional properties to replace or supplement the targeted tissue. This is still a challenge to overcome before tissue-engineered products can be considered a complete success. Classical tissue engineering approaches rely on the use of mature cells expanded in vitro and transplanted alone or seeded in passive 3D scaffolds, which can lead to the loss of cellular phenotype and production of nonfunctional extracellular matrix. An emerging strategy involves the design of bioactive 3D scaffolds with instructive properties able to recruit cells in situ and direct tissue formation. Here, we present and discuss recent efforts to achieve smart scaffolds encompassing macromolecular biofunctionalization and surface design.

Type
Research Article
Copyright
Copyright © Materials Research Society 2010

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References

1.Behrens, P., Bitter, T., Kurz, B., Russlies, M., Th Knee 13, 194 (2006).CrossRefGoogle Scholar
2.Pavesio, A.Abatangelo, G., Borrione, A., Brocchetta, D., Hollander, A.P., Kon, E., Torasso, F., Zanasi, S., Marcacci, M., Novartis Foundation Symp 249, 203 (2003).Google Scholar
3.Sadick, N., Sorhaindo, L., Expert Rev. Med Devices 4, 559 (2007).CrossRefGoogle Scholar
4.Arnesen, H., Lunde, K., Aakhus, S., Forfang, K., Lancet 369, 2142 (2007).CrossRefGoogle Scholar
5.Takahashi, J., Expert Rev. Neurother. 7, 667 (2007).CrossRefGoogle Scholar
6.Brittberg, M., Peterson, L., Sjogren-Jansson, E.Tallheden, T., Lindahl, A., J. Bone Joint Surg. Am 85-A (Suppl. 3), 109 (2003).CrossRefGoogle Scholar
7.Varghese, S., Hwang, N.S., Canver, A.C., Theprungsirikul, P., Lin, D.W., Elisseeff, J., Matrix Biol. 27, 12 (2007).CrossRefGoogle Scholar
8.Elisseeff, J., Puleo, C., Yang, F., Sharma, B., Orthod. Craniofac. Res. 8, 150 (2005).CrossRefGoogle Scholar
9.Hollister, S.J., Nat. Mater. 4, 518 (2005).CrossRefGoogle Scholar
10.Hutmacher, D.W., J. Biomater. Sci. Polym. Ed 12, 107 (2001).CrossRefGoogle Scholar
11.Moroni, L., Elisseeff, J.H., Materials Today 11 44 (2008).CrossRefGoogle Scholar
12.Sohier, J., Vlugt, T.J., Cabrol, N., Van Blitterswijk, C., de Groot, K., Bezemer, J.M., J Control Release 111, 95 (2006).CrossRefGoogle Scholar
13.Wang, Y., Bansal, V., Zelikin, A.N., Caruso, F.Nano Lett. 8, 1741 (2008).CrossRefGoogle Scholar
14.Kong, H.J., Mooney, D.J., Nat. Rev. Drug Discov. 6, 455 (2007).CrossRefGoogle Scholar
15.Lutolf, M.P., Hubbell, J.A., Nat. Biotechnol. 23, 47 (2005).CrossRefGoogle Scholar
16.Dalby, M.J., Gadegaard, N., Tare, R., Andar, A., Riehle, M.O., Herzyk, P., Wilkinson, C.D., Oreffo, R.O., Nat. Mater. 6, 997 (2007).CrossRefGoogle Scholar
17.Ruiz, S.A., Chen, C.S., Stem Cells 26, 2921 (2008).CrossRefGoogle Scholar
18.Alsberg, E., von Recum, H.A., Mahoney, M.J., Expert Opin. Biol. Ther. 6, 847 (2006).CrossRefGoogle Scholar
19.Mrksich, M., Dike, L.E., Tien, J., Ingber, D.E., Whitesides, G.M., Exp. Cell Res. 235, 305 (1997).CrossRefGoogle Scholar
20.Engler, A.J., Sen, S., Sweeney, H.L., Discher, D.E., Cell 126, 677 (2006).CrossRefGoogle ScholarPubMed
21.Evans, N.D., Minelli, C., Gentleman, E., LaPointe, V., Patankar, S.N., Kallivretaki, M., Chen, X., Roberts, C.J., Stevens, M.M., Eur. Cell. Mater. 18, 1 (2009).CrossRefGoogle Scholar
22.Fischbach, C., Mooney, D.J., Biomaterials 28, 2069 (2007).CrossRefGoogle Scholar
23.Chen, R.R., Silva, E.A., Yuen, W.W., Brock, A.A., Fischbach, C., Lin, A.S., Guldberg, R.E., Mooney, D.J., FASEB J. 21, 3896 (2007).CrossRefGoogle Scholar
24.Park, J.Y., Kim, S.K., Woo, D.H., Lee, E.J., Kim, J.H., Lee, S.H., Stem Cells 27, 2646 (2009).CrossRefGoogle ScholarPubMed
25.Shamloo, A., Ma, N., Poo, M.M., Sohn, L.L., Heilshorn, S.C., Lab Chip 8, 1292 (2008).CrossRefGoogle Scholar
26.Silva, E.A., Mooney, D.J., Biomaterials 31, 1235 (2010).CrossRefGoogle Scholar
27.Langer, R., Nature 392, 5 (1998).Google Scholar
28.Kang, C.E., Poon, P.C., Tator, C.H., Shoichet, M.S., Tissue Eng. Part A 15, 595 (2009).CrossRefGoogle Scholar
29.Sawyer, A.A., Song, S.J., Susanto, E., Chuan, P., Lam, C.X., Woodruff, M.A., Hutmacher, D.W., Cool, S.M., Biomaterials 30, 2479 (2009).CrossRefGoogle Scholar
30.Sakiyama-Elbert, S.E., Panitch, A., Hubbell, J.A., FASEB J. 15, 1300 (2001).CrossRefGoogle Scholar
31.Ehrbar, M., Djonov, V.G., Schnell, C., Tschanz, S.A., Martiny-Baron, G., Schenk, U., Wood, J., Burri, P.H., Hubbell, J.A., Zisch, A.H., Circ. Res. 94, 1124 (2004).CrossRefGoogle Scholar
32.Lutolf, M.P., Weber, F.E., Schmoekel, H.G., Schense, J.C., Kohler, T., Muller, R., Hubbell, J.A., Nat. Biotechnol. 21, 513 (2003).CrossRefGoogle Scholar
33.Jay, S.M., Shepherd, B.R., Andrejecsk, J.W., Kyriakides, T.R., Pober, J.S., Saltzman, W.M., Biomaterials 31, 3054 (2010).CrossRefGoogle Scholar
34.Hsieh, P.C.H., Davis, M.E., Gannon, J., MacGillivray, C., Lee, R.T., J. Clin. Invest. 116, 237 (2006).CrossRefGoogle Scholar
35.Borselli, C., Storrie, H., Benesch-Lee, F., Shvartsman, D., Cezar, C., Lichtman, J.W., Vandenburgh, H.H., Mooney, D.J., Proc. Natl. Acad. Sci. U.S.A. 107, 3287 (2010).CrossRefGoogle Scholar
36.Young, S., Patel, Z.S., Kretlow, J.D., Murphy, M.B., Mountziaris, P.M., Baggett, L.S., Ueda, H., Tabata, Y., Jansen, J.A., Wong, M., Mikos, A.G., Tissue Eng. Part A 15, 2347 (2009).CrossRefGoogle Scholar
37.Sun, Q., Silva, E.A., Wang, A., Fritton, J.C., Mooney, D.J., Schaffler, M.B., Grossman, P.M., Rajagopalan, S., Pharm. Res. 27, 264 (2010).CrossRefGoogle Scholar
38.Yilgor, P., Tuzlakoglu, K., Reis, R.L., Hasirci, N., Hasirci, V., Biomaterials 30, 3551 (2009).CrossRefGoogle Scholar
39.Curran, J.M., Chen, R., Hunt, J.A., Biomaterials 27, 4783 (2006).CrossRefGoogle Scholar
40.Curran, J.M., Chen, R., Hunt, J.A., Biomaterials 31, 1463 (2010).Google Scholar
41.DeForest, C.A., Polizzotti, B.D., Anseth, K.S., Nat. Mater. 8, 659 (2009).CrossRefGoogle Scholar
42.Kloxin, A.M., Kasko, A.M., Salinas, C.N., Anseth, K.S., Science 324, 59 (2009).CrossRefGoogle Scholar
43.Kim, J., Yoon, J., Hayward, R.C., Nat. Mater. 9, 159 (2010).CrossRefGoogle Scholar
44.Saha, K., Pollock, J.F., Schaffer, D.V., Healy, K.E., Curr. Opin. Chem. Biol. 11, 381 (2007).CrossRefGoogle Scholar
45.Zhang, K.C., Sugawara, A., Tirrell, D.A., Chembiochem 10, 2617 (2009).CrossRefGoogle Scholar
46.Comisar, W.A., Hsiong, S.X., Kong, H.J., Mooney, D.J., Linderman, J.J., Biomaterials 27, 2322 (2006).CrossRefGoogle Scholar
47.Patel, S., Tsang, J., Harbers, G.M., Healy, K.E., Li, S., J. Biomed. Mater. Res. A 83, 423 (2007).CrossRefGoogle Scholar
48.Hsiong, S.X., Huebsch, N., Fischbach, C., Kong, H.J., Mooney, D.J., Biomacromol. 9, 1843 (2008).CrossRefGoogle Scholar
49.Cushing, M.C., Liao, J.T., Jaeggli, M.P., Anseth, K.S., Biomater. 28, 3378 (2007).CrossRefGoogle Scholar
50.Weber, L.M., Hayda, K.N., Haskins, K., Anseth, K.S., Biomater. 28, 3004 (2007).CrossRefGoogle Scholar
51.Gunn, J.W., Turner, S.D., Mann, B.K., J. Biomed. Mater. Res. A 72, 91 (2005).CrossRefGoogle Scholar
52.Hwang, N.S., Varghese, S., Lee, H.J., Theprungsirikul, P., Canver, A., Sharma, B., Elisseeff, J., FEBS Lett. 581, 4172 (2007).CrossRefGoogle Scholar
53.Raeber, G.P., Lutolf, M.P., Hubbell, J.A., Biophys. J. 89, 1374 (2005).CrossRefGoogle Scholar
54.Lutolf, M.P., Lauer-Fields, J.L., Schmoekel, H.G., Metters, A.T., Weber, F.E., Fields, G.B., Hubbell, J.A., Proc. Natl. Acad. Sci. U.S.A. 100, 5413 (2003).CrossRefGoogle Scholar
55.Gelain, F., Horii, A., Zhang, S., Macromol. Biosci. 7, 544 (2007).CrossRefGoogle Scholar
56.Hartgerink, J.D., Beniash, E., Stupp, S.I., Science 294, 1684 (2001).CrossRefGoogle Scholar
57.Mata, A., Hsu, L., Capito, R., Aparicio, C., Henrikson, K., Stupp, S.I., Soft Mat. 5, 1228 (2009).CrossRefGoogle Scholar
58.Capito, R.M., Azevedo, H.S., Velichko, Y.S., Mata, A., Stupp, S.I., Science 319, 1812 (2008).CrossRefGoogle Scholar
59.Cui, H., Muraoka, T., Cheetham, A.G., Stupp, S.I., Nano Lett. 9, 945 (2009).CrossRefGoogle Scholar
60.Mei, Y., Cannizzaro, C., Park, H., Xu, Q., Bogatyrev, S.R., Yi, K., Goldman, N., Langer, R., Anderson, D.G., Small 4, 1600 (2008).CrossRefGoogle Scholar
61.Curran, J.M., Chen, R., Stokes, R., Irvine, E., Graham, D., Gubbins, E., Delaney, D., Amro, N., Sanedrin, R., Jamil, H., Hunt, J.A., J. Mater. Sci. Mater. Med. 21, 1021 (2009).CrossRefGoogle Scholar
62.Thapa, A., Webster, T.J., Haberstroh, K.M., J. Biomed. Mater. Res. A 67, 1374 (2003).CrossRefGoogle Scholar
63.Thapa, A., Miller, D.C., Webster, T.J., Haberstroh, K.M., Biomater. 24, 2915 (2003).CrossRefGoogle Scholar
64.Claase, M.B., Olde Riekerink, M.B., de Bruijn, J.D., Grijpma, D.W., Engbers, G.H., Feijen, J., Biomacromol. 4, 57 (2003).CrossRefGoogle Scholar
65.Chim, H., Ong, J.L., Schantz, J.T., Hutmacher, D.W., Agrawal, C.M., J. Biomed. Mater. Res. A 65, 327 (2003).CrossRefGoogle Scholar
66.Nelea, V., Luo, L., Demers, C.N., Antoniou, J., Petit, A., Lerouge, S., Wertheimer, R., Mwale, F., J. Biomed. Mater. Res. A 75, 216 (2005).CrossRefGoogle Scholar
67.Lipski, A.M., Jaquiery, C., Choi, H., Eberli, D., Stevens, M., Martin, I., Chen, I.W., Shastri, V.P., Adv. Mater. 19, 553 (2007).CrossRefGoogle Scholar
68.Li, W.J., Tuli, R., Huang, X., Laquerriere, P., Tuan, R.S., Biomater. 26, 5158 (2005).CrossRefGoogle Scholar
69.Jackman, R.J., Brittain, S.T., Adams, A., Prentiss, M.G., Whitesides, G.M., Science 280, 2089 (1998).CrossRefGoogle Scholar
70.Csucs, G., Michel, R., Lussi, J.W., Textor, M., Danuser, G., Biomaterials 24, 1713 (2003).CrossRefGoogle Scholar
71.Flaim, C.J., Chien, S., Bhatia, S.N., Nat. Methods 2, 119 (2005).CrossRefGoogle Scholar
72.Moroni, L., Lee, L.P., J. Biomed. Mater. Res. A 88, 644 (2009).CrossRefGoogle Scholar
73.Flemming, R.G., Murphy, C.J., Abrams, G.A., Goodman, S.L., Nealey, P.F., Biomaterials 20, 573 (1999).CrossRefGoogle Scholar
74.Duncan, A.C., Rouais, F., Lazare, S., Bordenave, L., Baquey, C., Colloids Surf. 54, 150 (2007).CrossRefGoogle Scholar
75.Dalby, M.J., Andar, A., Nag, A., Affrossman, S., Tare, R., McFarlane, S., Oreffo, R.O., J. R. Soc., Interface 5, 1055 (2008).CrossRefGoogle Scholar
76. P. De Biase, Capanna, R., Injury 36 (Suppl. 3), S43 (2005).Google Scholar
77.Habibovic, P., de Groot, K., J. Tissue Eng. Regen. Med. 1, 25 (2007).CrossRefGoogle Scholar
78.Habibovic, P., Yuan, H., van den Doel, M., Sees, T.M., van Blitterswijk, C.A., de Groot, K., J. Orthop. Res. 24, 867 (2006).CrossRefGoogle Scholar
79.Anderson, D.G., Levenberg, S., Langer, R., Nat. Biotechnol. 22, 863 (2004).CrossRefGoogle Scholar
80.Truckenmuller, R., Giselbrecht, S., van Blitterswijk, C., Dambrowsky, N., Gottwald, E., Mappes, T., Rolletschek, A., Saile, V., Trautmann, C., Weibezahn, K.F., Welle, A., Lab Chip 8, 1570 (2008).CrossRefGoogle Scholar
81.Flaim, C.J., Teng, D., Chien, S., Bhatia, S.N., Stem Cells Dev. 17, 29 (2008).CrossRefGoogle Scholar
82.Papenburg, B., Vogelaar, L., Bolhuis-Versteeg, L., Lammertink, R., Stamatialis, D., Wessling, M., Biomaterials 28, 1998 (2007).CrossRefGoogle Scholar
83.Figallo, E., Flaibani, M., Zavan, B., Abatangelo, G., Elvassore, N., Biotechnol. Prog. 23, 210 (2007).CrossRefGoogle Scholar
84.Choi, N.W., Cabodi, M., Held, B., Gleghorn, J.P., Bonassar, L.J., Stroock, A.D., Nat. Mater. 6, 908 (2007).CrossRefGoogle Scholar
85.Rivron, N.C., Rouwkema, J., Truckenmuller, R., Karperien, M., De Boer, J., van Blitterswijk, C.A., Biomater. 30, 4851 (2009).CrossRefGoogle Scholar
86.Groenendijk, M., Laser Technik Journal 3, 44 (2008).CrossRefGoogle Scholar
87.Groenendijk, M., Meijer, J., Journal of Laser Applications 18, 227 (2006).CrossRefGoogle Scholar

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