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In Vivo Dopamine Detection and Single Unit Recordings Using Intracortical Glassy Carbon Microelectrode Arrays

Published online by Cambridge University Press:  23 January 2018

Elisa Castagnola ,
Nasim Winchester Vahidi ,
Surabhi Nimbalkar ,
Srihita Rudraraju ,
Marvin Thielk ,
Elena Zucchini ,
Claudia Cea ,
Stefano Carli ,
Timothy Q. Gentner  and
Davide Ricci
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Elisa Castagnola*
Affiliation:
MEMS Research Lab., Department of Mechanical Engineering, College of Engineering, San Diego State University, 5500 Campanile Drive, San Diego, CA92182-1323, USA Center for Sensorimotor Neural Engineering (CSNE), Box 37, 1414 NE 42nd St., Suite 204, Seattle, WA98105-6271, USA.
Nasim Winchester Vahidi
Affiliation:
Dept. of Electrical Engineering, University of California San Diego, La Jolla, CA92093, USA Neurosciences Graduate Program, University of California San Diego, 9500Gilman Dr, La Jolla, CA, USA
Surabhi Nimbalkar
Affiliation:
MEMS Research Lab., Department of Mechanical Engineering, College of Engineering, San Diego State University, 5500 Campanile Drive, San Diego, CA92182-1323, USA Center for Sensorimotor Neural Engineering (CSNE), Box 37, 1414 NE 42nd St., Suite 204, Seattle, WA98105-6271, USA.
Srihita Rudraraju
Affiliation:
Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
Marvin Thielk
Affiliation:
Neurosciences Graduate Program, University of California San Diego, 9500Gilman Dr, La Jolla, CA, USA
Elena Zucchini
Affiliation:
Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia, Via Fossato di Mortara 17/19, 44121, Ferrara, Italy
Claudia Cea
Affiliation:
MEMS Research Lab., Department of Mechanical Engineering, College of Engineering, San Diego State University, 5500 Campanile Drive, San Diego, CA92182-1323, USA Center for Sensorimotor Neural Engineering (CSNE), Box 37, 1414 NE 42nd St., Suite 204, Seattle, WA98105-6271, USA.
Stefano Carli
Affiliation:
Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia, Via Fossato di Mortara 17/19, 44121, Ferrara, Italy
Timothy Q. Gentner
Affiliation:
Neurosciences Graduate Program, University of California San Diego, 9500Gilman Dr, La Jolla, CA, USA
Davide Ricci
Affiliation:
Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
Luciano Fadiga
Affiliation:
Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia, Via Fossato di Mortara 17/19, 44121, Ferrara, Italy Human Physiology, University of Ferrara, Via Fossato di Mortara 17/19, 44121, Ferrara, Italy.
Sam Kassegne
Affiliation:
MEMS Research Lab., Department of Mechanical Engineering, College of Engineering, San Diego State University, 5500 Campanile Drive, San Diego, CA92182-1323, USA Center for Sensorimotor Neural Engineering (CSNE), Box 37, 1414 NE 42nd St., Suite 204, Seattle, WA98105-6271, USA.
*
*(Email: ecastagnola@sdsu.edu)
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Abstract

In this study, we present a 4-channel intracortical glassy carbon (GC) microelectrode array on a flexible substrate for the simultaneous in vivo neural activity recording and dopamine (DA) concentration measurement at four different brain locations (220µm vertical spacing). The ability of GC microelectrodes to detect DA was firstly assessed in vitro in phosphate-buffered saline solution and then validated in vivo measuring spontaneous DA concentration in the Striatum of European Starling songbird through fast scan cyclic voltammetry(FSCV). The capability of GC microelectrode arrays and commercial penetrating metal microelectrode arrays to record neural activity from the Caudomedial Neostriatum of European starling songbird was compared. Preliminary results demonstrated the ability of GC microelectrodes in detecting neurotransmitters release and recording neural activity in vivo. GC microelectrodes array may, therefore, offer a new opportunity to understand the intimate relations linking electrophysiological parameters with neurotransmitters release.

Keywords

sensordevicesmicroelectronics
Type
Articles
Information
MRS Advances , Volume 3 , Issue 29: Biomaterials and Soft Materials , 2018 , pp. 1629 - 1634
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Copyright
Copyright © Materials Research Society 2018 

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References

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