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Self-Limiting Aggregation By Controlled Ligand-Receptor Stoicfflometry and Its Use For a Novel Drug Delivery System

Published online by Cambridge University Press:  02 July 2020

E. Kisak ,
M. Kennedy  and
J. A. Zasadzinski
E. Kisak
Affiliation:
Department of Chemical Engineering and Materials Research Laboratory University of California, Santa Barbara, CA93106
M. Kennedy
Affiliation:
Department of Chemical Engineering and Materials Research Laboratory University of California, Santa Barbara, CA93106
J. A. Zasadzinski
Affiliation:
Department of Chemical Engineering and Materials Research Laboratory University of California, Santa Barbara, CA93106
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Extract

Lipid vesicles are used as drug delivery vehicles for the slow sustained release of a drug compound to a specific site in the body. This translates to more efficient medication with limited side effects. Although unilamellar drug delivery vesicles have progressed greatly, they are still limited in there applications. Our group has designed a second generation drug release system, the “vesosome“ which incorporates an aggregate of lipid vesicles encapsulated in a second lipid membrane. The two separate membranes can be specialized to allow for increased drug encapsulation and better control over drug release rate, which leads to a more general drug delivery system.

Lipid vesicle aggregates were formed by using a ligand-receptor system (biotinated lipids protruding from the vesicle surface crosslinked with streptavidin). The streptavidin/biotin system is one of the strongest in nature, providing specific binding.

Type
Biopolymers and Biomemetics
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1212 - 1213
Copyright
Copyright © Microscopy Society of America

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References

1.Walker, S.A., et al., Encapsulation of bilayer vesicles by self-assembly. Nature, 387, 61–64 (1997).Google Scholar
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