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Low-Dose Scanning Electron Diffraction Microscopy of Mechanochemically Nanostructured Pharmaceuticals

Published online by Cambridge University Press:  05 August 2019

Duncan N. Johnstone*
Affiliation:
Department of Materials Science & Metallurgy, University of Cambridge, Cambridge, UK.
Christopher S. Allen
Affiliation:
Department of Materials, University of Oxford, Oxford, UK. Electron Physical Sciences Imaging Centre (ePSIC), Diamond Light Source, Harwell, UK.
Mohsen Danaie
Affiliation:
Electron Physical Sciences Imaging Centre (ePSIC), Diamond Light Source, Harwell, UK.
Royston C.B. Copley
Affiliation:
Physical Properties, CMC Analytical, GlaxoSmithKline Pharmaceuticals, Stevenage, UK.
Jeffrey Brum
Affiliation:
Physical Properties, CMC Analytical, GlaxoSmithKline Pharmaceuticals, Collegeville, USA.
Angus I. Kirkland
Affiliation:
Department of Materials, University of Oxford, Oxford, UK. Electron Physical Sciences Imaging Centre (ePSIC), Diamond Light Source, Harwell, UK.
Paul A. Midgley
Affiliation:
Department of Materials Science & Metallurgy, University of Cambridge, Cambridge, UK.
*
*Corresponding author: dnj23@cam.ac.uk

Abstract

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Type
Spectroscopy and Imaging of Nanostructured Low-Z Materials in the Electron Microscope
Copyright
Copyright © Microscopy Society of America 2019 

References

[1]Eddleston, MD & Jones, W in “Disordered Pharmaceutical Materials”, ed. Descamps, M, (Wiley-VCH Verlag GmbH & Co, Weinheim) (2016), pp. 103-134.Google Scholar
[2]Johnstone, DN & Midgley, PA, Microsc. Microanal. 23 (2017), p. 1192.Google Scholar
[3]Panova, O et al. , Micron, 88 (2016,) p. 30.Google Scholar
[4]Kaki, S et al. , Advanced Materials 21 (2009), p. 3905.Google Scholar
[5]Hasa, D & Jones, W, Adv. Drug Deliv. Rev. 117 (2017), p. 147.Google Scholar
[6]The authors acknowledge financial support from the GSK-Cambridge Varsity Alliance. We thank Diamond Light Source Ltd. for access and support in the use of the electron Physical Science Imaging Centre (EM16983, EM17991, EM18488, EM20527).Google Scholar