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Conformational Changes in HIV-1 Env Trimer Induced by a Single CD4 as Revealed by Cryo-EM

Published online by Cambridge University Press:  04 August 2017

Priyamvada Acharya ,
Qingbo Liu ,
Xiaochu Ma ,
Maolin Lu ,
Venkat Dandey ,
Edward T Eng ,
William J Rice ,
Christoph Wigge ,
Tatsiana Bylund  and
Gwo-Yu Chuang
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Priyamvada Acharya
Affiliation:
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA
Qingbo Liu
Affiliation:
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Xiaochu Ma
Affiliation:
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Maolin Lu
Affiliation:
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Venkat Dandey
Affiliation:
National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA
Edward T Eng
Affiliation:
National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA
William J Rice
Affiliation:
National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA
Christoph Wigge
Affiliation:
National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA
Tatsiana Bylund
Affiliation:
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Gwo-Yu Chuang
Affiliation:
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Aliaksandr Druz
Affiliation:
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Hui Geng
Affiliation:
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Jason Gorman
Affiliation:
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Tongqing Zhou
Affiliation:
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Walther Mothes
Affiliation:
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Paolo Lusso
Affiliation:
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Bridget Carragher
Affiliation:
National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA
Clinton S Potter
Affiliation:
National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA
Peter D Kwong
Affiliation:
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA

Abstract

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Abstract
Information
Microscopy and Microanalysis , Volume 23 , Supplement S1: Proceedings of Microscopy & Microanalysis 2017 , July 2017 , pp. 1190 - 1191
Copyright
© Microscopy Society of America 2017 

References

[1] Acharya, P, et al, Expert Opin Ther Targets 19 2015). p. 765.Google Scholar
[2] Kwong, PD, et al, Nature 393 1998). p. 648.Google Scholar
[3] Kwon, YD, et al, Nat Struc Mol Biol 22 2015). p. 522.Google Scholar
[4] Liu, Q, et al, Nat Struc Mol Biol (in press).Google Scholar
[5] Munro, J B, et al, Science 346 2014). p. 759.Google Scholar