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Alterations In Glutamate Synapses In The Nucleus Accumbens Following Sensitization To Cocaine

Published online by Cambridge University Press:  02 July 2020

L. B. Kozell  and
C. K. Meshul
L. B. Kozell
Affiliation:
Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, OR97201
C. K. Meshul
Affiliation:
Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, OR97201 VA Medical Center, Portland, OR97201
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Extract

Repeated intermittent administration of cocaine to rodents has been shown to result in behavioral sensitization, or enhanced locomotor activity. Because there are similarities between effects of intermittent cocaine use in humans and sensitization in rats, understanding the neural mechanism underlying sensitization may provide insights into mechanisms of psychopathologies in humans.

There is abundant evidence that the mesolimbic dopaminergic pathways, originating in the ventral tegmental area (VTA) and terminating in both nucleus accumbens (NAc) and prefrontal cortex (PFC), are critically important for development of sensitization to the motor-stimulating effects of cocaine. Evidence also suggests that changes in glutamate (Glu) transmission in the mesolimbic DA pathways are associated with sensitization to cocaine. In recent collaborative studies, we have shown that cocaine administration transiently decreases the density of nerve terminal glutamate immunolabeling within the NAc shell following withdrawal from continuous or intermittent cocaine administration. Locomotor activity was not assessed in either of these studies.

Type
Highlights Of Biological Microscopy In The Pacific Northwest Usa
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1232 - 1233
Copyright
Copyright © Microscopy Society of America

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References

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