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Fatal Encephalitis In Young Children, Taiwan, 1998

Published online by Cambridge University Press:  02 July 2020

Cynthia S. Goldsmith ,
Wun-Ju Shieh ,
Mark A. Pallansch ,
Thomas G. Ksiazek ,
Chuen Hsueh ,
Shih-Ming Jung ,
Tseng-Tong Kuo ,
Yi-Ping Chen  and
Sherif R. Zaki
Cynthia S. Goldsmith
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia30333
Wun-Ju Shieh
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia30333
Mark A. Pallansch
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia30333
Thomas G. Ksiazek
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia30333
Chuen Hsueh
Affiliation:
Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China
Shih-Ming Jung
Affiliation:
Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China
Tseng-Tong Kuo
Affiliation:
Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China
Yi-Ping Chen
Affiliation:
Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China
Sherif R. Zaki
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia30333
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Extract

During April-July 1998, an increase in fatal cases of neurologic disease in young children occurred in Taiwan, with at least 55 fatalities reported. Concurrently, an outbreak of hand, foot, and mouth disease (HFMD) was also occurring. In fatal cases, the acute illness was characterized by fever, or rash, or mouth ulcers, followed by a rapid cardiopulmonary failure; death frequently occurred within 24 hours of hospitalization. Approximately three-fourths of the fatalities were in children less than 3 years of age. We report here the findings from autopsy specimens from two of the fatal cases of encephalomyelitis.

In Case 1, a 9-year-old female, H&E sections of central neurologic system (CNS) tissue showed perivascular infiltrate, areas of inflammation, necrosis, and neuronal degeneration. Immunohistochemical (IHC) staining was positive when using a monoclonal antibody for enterovirus 71 (EV71), a picornavirus associated with HFMD.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1146 - 1147
Copyright
Copyright © Microscopy Society of America

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References

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