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From Quasispecies Theory to Viral Quasispecies: How Complexity has Permeated Virology

Published online by Cambridge University Press:  17 October 2012

E. Domingo  and
C. Perales
E. Domingo*
Affiliation:
Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM) Campus de Cantoblanco 28049, Madrid, Spain Centro de Astrobiología (CSIC-INTA), Instituto Nacional de Técnica Aeroespacial Ctra. de Torrejón a Ajalvir, Km 4, 28850 Torrejón de Ardoz, Madrid, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08036 Barcelona, Spain
C. Perales
Affiliation:
Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM) Campus de Cantoblanco 28049, Madrid, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08036 Barcelona, Spain
*
⋆ Corresponding author. E-mail: edomingo@cbm.uam.es
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Abstract

RNA viruses replicate as complex and dynamic mutant distributions. They are termed viral quasispecies, in recognition of the fundamental contribution of quasispecies theory in our understanding of error-prone replicative entities. Viral quasispecies have launched a fertile field of transdiciplinary research, both experimental and theoretical. Here we review the origin and some implications of the quasispecies concept, with emphasis on internal interactions among components of the same mutant virus ensemble, a critical fact to design new antiviral strategies. We make the distinction between “intrinsic” and “extrinsic” properties of mutant distributions, and emphasize that there are several levels of complexity that can influence viral quasispecies behavior.

Keywords

RNA virusesviral quasispeciesmutation rateviral fitnesslethal mutagenesis
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 7 , Issue 5: Immunology , 2012 , pp. 105 - 122
Copyright
© EDP Sciences, 2012

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