Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-19T11:51:39.891Z Has data issue: false hasContentIssue false
  • English
  • Français

The Effect of Narcotics on the Endogenous Respiration and Succinate Oxidation in Oyster Muscle

Published online by Cambridge University Press:  11 May 2009

George Frederick Humphrey
George Frederick Humphrey
Affiliation:
Department of Biochemistry, University of Sydney, Australia
Get access Rights & Permissions [Opens in a new window]

Extract

The action of the following compounds on homogenates of the adductor muscles of Saxostrea commercialis was studied: urethane, phenyl urethane, chloral hydrate, salicylic acid, morphine, caffeine, barbitone, benzoic acid, salicylamide and benzamide.

It was found that, except for 0·05 M urethane, the endogenous oxygen consumption was reduced by all these compounds when present in concentrations ranging from o·001 to 0·05M. The oxidation of succinic acid was partially inhibited by these substances.

These findings are discussed in relation to similar studies on other tissues.

Type
Research Article
Information
Journal of the Marine Biological Association of the United Kingdom , Volume 27 , Issue 2 , April 1948 , pp. 504 - 512
Copyright
Copyright © Marine Biological Association of the United Kingdom 1948

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Anschütz, R., 1919. Über ein neues Disalicylid. Ber., Vol. LII, pp. 1875–95.Google Scholar
Barnes, M. R., 1944. The metabolism of the developing Rana pipiens as revealed by specific inhibitors. Journ. Exp. Zool., Vol. XCV, pp. 399–417.Google Scholar
Boyland, E., 1928. Chemical changes in muscle. Part I. Invertebrate muscle. Part 2. Vertebrate cardiac muscle. Biochem. Journ., Vol. XXII, pp. 362–80.CrossRefGoogle Scholar
Cheney, R. H., 1946. The effects of caffeine on the oxygen consumption and cell division in the fertilized egg of the sea urchin, Arbacia punctulata. Journ. Gen. Physiol., Vol. XXIX, pp. 63–72.Google Scholar
Clark, A. J., 1937. The action of narcotics on enzymes and cells. Trans. Farad. Soc., Vol. XXXIII, pp. 1057–61.CrossRefGoogle Scholar
Greig, M. E., 1946. The site of action of narcotics on brain metabolism. Journ. Pharm. Exp. Ther., Vol. LXXXVII, pp. 185–92.Google Scholar
Humphrey, G. F., 1943. Glycolysis in extracts of oyster muscle. Aust. Journ. Exp. Biol. Med. Sci., Vol. XXII, pp. 135–38.Google Scholar
Humphrey, G. F., 1946. The endogenous respiration of homogenates of oyster muscle. Aust. Journ. Exp. Biol. Med. Sci., Vol. XXIV, pp. 261–67.CrossRefGoogle Scholar
Humphrey, G. F., 1947. The succinoxidase system in oyster muscle. Journ. Exp. Biol., Vol. XXIV, pp. 352–60.Google Scholar
Jowett, M. & Quastel, J. H., 1937. The effects of narcotics on tissue oxidations. Biochem. Journ., Vol. XXXI, pp. 565–78.CrossRefGoogle Scholar
Keilin, D. & Hartree, E. F., 1937. Preparation of pure cytochrome c from heart muscle and some of its properties. Proc. Roy. Soc. Lond., B, Vol. CXXII, pp. 298–308.Google Scholar
Keys, A., 1937. Contributions to the theory of narcosis. Trans. Farad. Soc., Vol. XXXIII, pp. 1064–65.Google Scholar
Kobayashi, S., 1929. Lactic acid and glycogen in the adductor muscles of the oyster, Ostrea circumpicta Pils. Sci. Rep. Tohoku Imp. Univ., Vol. IV, Ser. 4, pp. 193–205.Google Scholar
Krogh, A., 1915. Ethyl urethane as a narcotic for aquatic animals. Internat. Rev. Hydrobiol. Hydrograph., Vol. VII, pp. 42–47.Google Scholar
Marceau, F., 1909. Recherches sur la morphologic, l'histologie et la physiologie comparées des muscles adducteurs des mollusques acephales. Arch. Zool. exp. gen., T. II, Ser. 5, pp. 295–469.Google Scholar
Michaelis, M. & Quastel, J. H., 1941. The site of action of narcotics in respiratory processes. Biochem. Journ., Vol. XXXV, pp. 518–33.CrossRefGoogle Scholar
Moog, F. & Spiegelman, S., 1942. Some effects of respiratory inhibitors on respiration and reconstitution in Tubularia. Proc. Soc. Exp. Biol. Med., Vol. XLIX, pp. 392–95.Google Scholar
Navez, A. E., Crawford, J. D., Benedict, D. & Dubois, A. B., 1941. On the metabolism of the heart of Venus mercenaria. Biol. Bull. Woods Hole, Vol. LXXXI, p. 289.Google Scholar
Östergren, G., 1944. Colchicine mitosis, chromosome contraction, narcosis, and protein chain folding. Hereditas, Vol. XXX, pp. 429–67.Google Scholar
Parnas, J. K., 1910. Energetik glatter Muskeln. Pfluegers Arch. ges. Physiol., Bd. CXXXIV, pp. 441–95.CrossRefGoogle Scholar
Potter, V. R., 1941. Studies on the mechanism of hydrogen transport in animal tissues. IV. The succinoxidase system. Journ. Biol. Chem., Vol 141, pp. 775–87.CrossRefGoogle Scholar
Quastel, J. H. & Wheatley, A. H., 1933. Narcosis and oxidations of the brain. Proc. Roy. Soc. Lond., Vol. CXII, pp. 60–79.Google Scholar
Riesser, O., 1933. Fortgesetzte pharmacologische Untersuchungen an den Muskeln wirbelloser Meerestiere. Arch. exp. Path. Pharm., Bd. CLXXII, pp. 194–212.Google Scholar
Seevers, M. H. & Shideman, F. E., 1941. Effects of morphine and its derivatives on intermediate metabolism. I. The influence of morphine, codeine and thebaine on the activity of several dehydrogenases and on the respiration of rat cerebrum. J. Pharm. Exp. Ther., Vol. LXXI, pp. 373–82.Google Scholar
Shideman, F. E. & Seevers, M. H., 1941. Effects of morphine and its derivatives on intermediate metabolism. II. The influence of thiamin deficiency on the respiration of skeletal muscle and cocarboxylase content of tissues of normal and chronically morphinized rats. Journ. Pharm. Exp. Ther., Vol. LXXI, pp. 383–93.Google Scholar
Szent-Györgyi, A., 1937. Studies on biological oxidation and some of its catalysts. Acta med. Szeged., Vol. IX, pp. 1–79.Google Scholar
Warburg, O., 1914. Über Verbrennung der Oxalsäure an Blutkohle und die Hemmung dieser Reaktion durch indifferente Narkotica. Pfluegers Arch. ges. Physiol., Bd. CLV, pp. 547–66.CrossRefGoogle Scholar