Hostname: page-component-8448b6f56d-xtgtn Total loading time: 0 Render date: 2024-04-23T07:35:42.342Z Has data issue: false hasContentIssue false
  • English
  • Français

Social Cognition in Individuals with Progressive Multiple Sclerosis: A Pilot Study Using TASIT-S

Published online by Cambridge University Press:  17 January 2020

Helen M. Genova Open the ORCID record for Helen M. Genova [Opens in a new window]  and
Skye McDonald
Helen M. Genova*
Affiliation:
Kessler Foundation, 120 Eagle’Rock Ave, Suite 100, East Hanover, NJ, USA Rutgers, New Jersey Medical School, 90 Bergen Street, Suite 3100, Newark, NJ, USA
Skye McDonald
Affiliation:
School of Psychology, University of NSW, Sydney, 2052, NSW, Australia
*
*Correspondence and reprint requests to: Helen M. Genova, 120 Eagle Rock Ave, Suite 100, East Hanover, NJ 07936-3147, USA. E-mail: hgenova@kesslerfoundation.org
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

Individuals with multiple sclerosis (MS) can have difficulty on tasks requiring social cognition, including Theory of Mind (ToM) and facial affect recognition. However, most research on social cognition in MS has focused on Relapsing–Remitting MS; less is known about deficits in individuals with progressive MS. This pilot study examined the social cognitive abilities of individuals with progressive MS on a dynamic social cognition task: The Awareness of Social Inference Test – Short Form (TASIT-S).

Methods:

Fifteen individuals with progressive MS and 17 healthy controls performed TASIT-S, which includes 3 subtests assessing facial affect recognition and ToM.

Results:

The MS group was impaired on all subtests of TASIT-S, including Emotion Evaluation, Social Inference – Minimal, and Social Inference – Enriched, which examine facial affect recognition and ToM. Deficits on TASIT-S were significantly correlated with several cognitive abilities including working memory, learning memory, and verbal IQ.

Conclusions:

Our findings suggest individuals with progressive MS were impaired across multiple social cognition domains as assessed by the TASIT-S. Furthermore, social cognitive abilities were related to cognitive abilities such as visuospatial memory and executive abilities. Results are discussed in terms of social cognition deficits in MS and how they relate to cognitive abilities.

Keywords

Progressive multiple sclerosisTheory of mindSocial cognitionTASITTASIT-SEmotional processingCognition
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 26 , Issue 5 , May 2020 , pp. 539 - 544
Copyright
Copyright © INS. Published by Cambridge University Press, 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Benedict, R.H.B. (1997). Brief Visuospatial Memory Test-Revised professional manual. Odessa, FL: Psychological Assessment Resources, Inc.Google Scholar
Benton, A.L., Sivan, A.B., Hamsher, K., Varney, N.R., & Spreen, O. (1983). Contributions to neuropsychological assessment (2nd ed.). New York, NY: Oxford University Press.Google Scholar
Brochet, B., & Ruet, A. (2019). Cognitive impairment in multiple sclerosis with regards to disease duration and clinical phenotypes. Frontiers in Neurology, 10, 261. doi: 10.3389/fneur.2019.00261CrossRefGoogle ScholarPubMed
Ciampi, E., Uribe-San-Martin, R., Vásquez, M., Ruiz-Tagle, A., Labbe, T., Cruz, J.P., Lillo, P., Slachevsky, A., Reyes, D., Reyes, A., & Cárcamo-Rodríguez, C. (2018). Relationship between social cognition and traditional cognitive impairment in progressive multiple sclerosis and possible implicated neuroanatomical regions. Multiple Sclerosis and Related Disorders, 20, 122–128. doi: 10.1016/j.msard.2018.01.013CrossRefGoogle ScholarPubMed
Costa, S.L., Genova, H.M., Deluca, J., & Chiaravalloti, N.D. (2017). Information processing speed in multiple sclerosis: Past, present, and future. Multiple Sclerosis, 23(6), 772–789. doi: 10.1177/1352458516645869CrossRefGoogle ScholarPubMed
Cotter, J., Firth, J., Enzinger, C., Kontopantelis, E., Yung, A.R., Elliott, R., & Drake, R.J. (2016). Social cognition in multiple sclerosis. Neurology, 87(16), 1727–1736. doi: 10.1212/WNL.0000000000003236CrossRefGoogle ScholarPubMed
Delis, D.C., Kaplan, E., & Kramer, J.H. (2001). Delis–Kaplan executive function system (D-KEFS). San Antonio, TX: The Psychological Corporation.Google Scholar
Genova, H.M., Cagna, C.J., Chiaravalloti, N.D., DeLuca, J., & Lengenfelder, J. (2016). Dynamic assessment of social cognition in individuals with multiple sclerosis: A pilot study. Journal of the International Neuropsychological Society, 22(1), 83–88. doi: 10.1017/S1355617715001137CrossRefGoogle ScholarPubMed
Genova, H.M., Deluca, J., Chiaravalloti, N., & Wylie, G. (2013). The relationship between executive functioning, processing speed, and white matter integrity in multiple sclerosis. Journal of Clinical and Experimental Neuropsychology, 35(6), 631–641. doi: 10.1080/13803395.2013.806649CrossRefGoogle ScholarPubMed
Goeleven, E., De Raedt, R., Leyman, L., & Verschuere, B. (2008). The Karolinska directed emotional faces: A validation study. Cognition & Emotion, 22(6), 1094–1118. doi: 10.1080/02699930701626582CrossRefGoogle Scholar
Gronwall, D., & Wrightson, P. (1981). Memory and information processing capacity after closed head injury. Journal of Neurology, Neurosurgery, and Psychiatry, 44(10), 889–895. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=491173&tool=pmcentrez&rendertype=abstractCrossRefGoogle ScholarPubMed
Henry, J.D., Phillips, L.H., Beatty, W.W., McDonald, S., Longley, W.A., Joscelyne, A., & Rendell, P.G. (2009). Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis. Journal of the International Neuropsychological Society: JINS, 15(2), 277–285. doi: 10.1017/S1355617709090195CrossRefGoogle ScholarPubMed
Honan, C.A., McDonald, S., Gowland, A., Fisher, A., & Randall, R.K. (2015). Deficits in comprehension of speech acts after TBI: The role of theory of mind and executive function. Brain and Language, 150, 69–79. doi: 10.1016/j.bandl.2015.08.007CrossRefGoogle ScholarPubMed
Honan, C.A., McDonald, S., Sufani, C., Hine, D.W., & Kumfor, F. (2016). The awareness of social inference test: Development of a shortened version for use in adults with acquired brain injury. The Clinical Neuropsychologist, 30(2), 243–264. doi: 10.1080/13854046.2015.1136691CrossRefGoogle ScholarPubMed
McDonald, S., Flanagan, S., Rollins, J., & Kinch, J. (2003). TASIT: A new clinical tool for assessing social perception after traumatic brain injury. The Journal of Head Trauma Rehabilitation, 18(3), 219–238. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12802165CrossRefGoogle ScholarPubMed
Mike, A., Strammer, E., Aradi, M., Orsi, G., Perlaki, G., Hajnal, A., Sandor, J., Banati, M., Illes, E., Zaitsev, A., Herold, R., Guttmann, C.R., & Illes, Z. (2013). Disconnection mechanism and regional cortical atrophy contribute to impaired processing of facial expressions and theory of mind in multiple sclerosis: A structural MRI study. PloS One, 8(12), e82422. doi: 10.1371/journal.pone.0082422CrossRefGoogle ScholarPubMed
Pitteri, M., Genova, H., Lengenfelder, J., DeLuca, J., Ziccardi, S., Rossi, V., & Calabrese, M. (2019). Social cognition deficits and the role of amygdala in relapsing remitting multiple sclerosis patients without cognitive impairment. Multiple Sclerosis and Related Disorders, 29, 118–123. doi: 10.1016/j.msard.2019.01.030CrossRefGoogle ScholarPubMed
Polman, C.H., Reingold, S.C., Banwell, B., Clanet, M., Cohen, J.A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., Lublin, F.D., Montalban, X., O’Connor, P., Sandberg-Wollheim, M., Thompson, A.J., Waubant, E., Weinshenker, B., & Wolinsky, J.S. (2011). Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Annals of Neurology, 69(2), 292–302. doi: 10.1002/ana.22366CrossRefGoogle ScholarPubMed
Smith, A. (1982). Symbol digit modalities test: Manual. Los Angeles, CA: Western Psychological Services.Google Scholar