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Emotional valence and semantic relatedness differentially influence false recognition in mild cognitive impairment, Alzheimer’s disease, and healthy elderly

Published online by Cambridge University Press:  01 March 2009

KATJA BRUECKNER  and
STEFFEN MORITZ
KATJA BRUECKNER*
Affiliation:
Epilepsy Center Hamburg, Protestant Hospital Alsterdorf, Hamburg, Germany
STEFFEN MORITZ
Affiliation:
Department of Psychiatry & Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
*
*Correspondence and reprint requests to: Katja Brueckner, Epilepsy Center Hamburg, Protestant Hospital Alsterdorf, Bodelschwinghstr. 24, 22337 Hamburg, Germany. E-mail: k.brueckner@eka.alsterdorf.de
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Abstract

This study examined whether patients with mild cognitive impairment (MCI) who are at higher risk for later Alzheimer disease (AD) display deficits comparable to patients with diagnosed dementia. We assessed 27 patients with MCI, 36 patients with AD, and 20 healthy older adults with an emotional variant of the Deese–Roediger–McDermott-paradigm. Participants studied four lists that were semantically related to a nonpresented critical theme word. These theme words were either depression-related (i.e., loneliness) or delusion-related (betrayal) or had a positive (holidays) or neutral (window) valence. Despite a normal overall emotional memory and a normal corrected overall false recognition, patients with MCI, as predicted, produced as many false memories as patients with AD. On closer examination, both patient groups showed enhanced false memories to unrelated stimuli and a significant bias to falsely remember stimuli with a positive valence. We conclude that although patients with MCI are not distinguishable from healthy older adults in terms of their overall emotional recognition, positively valenced memories and more specifically false positive memories may represent the signature of a breakdown of emotional memory along the continuum between normal aging and AD. (JINS, 2009, 15, 268–276.)

Keywords

Cognitive disordersMemory disordersRecognitionNeurodegerative diseases
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 2 , March 2009 , pp. 268 - 276
Copyright
Copyright © INS 2009

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