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Differential Influence of 5-HTTLPR - Polymorphism and COMT Val158Met - Polymorphism on Emotion Perception and Regulation in Healthy Women

Published online by Cambridge University Press:  31 March 2014

Elisabeth M. Weiss ,
H. Harald Freudenthaler ,
Andreas Fink ,
Eva M. Reiser ,
Harald Niederstätter ,
Simone Nagl ,
Walther Parson  and
Ilona Papousek
Elisabeth M. Weiss*
Affiliation:
Department of Psychology, Biological Psychology Unit, University of Graz, Austria
H. Harald Freudenthaler
Affiliation:
Department of Psychology, Biological Psychology Unit, University of Graz, Austria
Andreas Fink
Affiliation:
Department of Psychology, Biological Psychology Unit, University of Graz, Austria
Eva M. Reiser
Affiliation:
Department of Psychology, Biological Psychology Unit, University of Graz, Austria
Harald Niederstätter
Affiliation:
Institute of Legal Medicine, Innsbruck Medical University, Innsbruck, Austria
Simone Nagl
Affiliation:
Institute of Legal Medicine, Innsbruck Medical University, Innsbruck, Austria
Walther Parson
Affiliation:
Institute of Legal Medicine, Innsbruck Medical University, Innsbruck, Austria Penn State Eberly College of Science, University Park, Pennsylvania
Ilona Papousek
Affiliation:
Department of Psychology, Biological Psychology Unit, University of Graz, Austria
*
Correspondence and reprint requests to: Elisabeth M. Weiss, University of Graz, Department of Psychology, Univ.-Platz 2, A-8010 Graz, Austria. E-mail: e.weiss@uni-graz.at.
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Abstract

Converging evidence indicates that a considerable amount of variance in self-estimated emotional competency can be directly attributed to genetic factors. The current study examined the associations between the polymorphisms of the Catechol-O-methyltransferase (COMT Met158Val) and the serotonin transporter (5-HTTLPR) and specific measures of the self-estimated effectiveness of an individual’s emotion perception and regulation. Emotional competence was measured in a large sample of 289 healthy women by using the Self-report Emotional Ability Scale (SEAS), which includes two subscales for the assessment of emotion perception and regulation in the intra-personal domain and two subscales for the assessment of emotion perception and regulation in the inter-personal domain. Participants’ reports of effective emotion regulation in everyday life were associated with the COMT Met-allele, with women homozygous for the Val-allele scoring lowest on this scale. Self-estimated effectiveness of emotion perception of the individual’s own emotions was related to the 5-HTTLPR. Both homozygous groups (s/s and l/l) rated their intra-personal emotion perception less effective than participants in the heterozygous s/l group. Taken together, the results indicate that genetic variants of the COMT and 5HTTLPR genes are differentially associated with specific measures of the self-estimated effectiveness of an individual’s emotion perception and regulation in the intra-personal domain. (JINS, 2014, 20, 1–9)

Keywords

Genetic polymorphismsCOMT5-HTTLPREmotion perceptionEmotion regulationEmotional competency
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 20 , Issue 5 , May 2014 , pp. 516 - 524
Copyright
Copyright © The International Neuropsychological Society 2014 

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References

Amstadter, A.B., Daughters, S.B., Macpherson, L., Reynolds, E.K., Danielson, C.K., Wang, F., … Lejuez, C.W. (2012). Genetic associations with performance on a behavioral measure of distress intolerance. Journal of Psychiatric Research, 46, 87–94. doi:10.1016/j.jpsychires.2011.09.017CrossRefGoogle ScholarPubMed
Antypa, N., Cerit, H., Kruijt, A.W., Verhoeven, F.E., & Van der Does, A.J. (2011). Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions. Neuroscience, 172, 303–313. doi:10.1016/j.neuroscience.2010.10.042CrossRefGoogle ScholarPubMed
Antypa, N., Drago, A., & Serretti, A. (2013). The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes. Neuroscience & Biobehavioral Reviews., Sep, 37(8), 1597–1610. doi:10.1016/j.neubiorev.2013.06.006Google Scholar
Bamonti, P.M., Heisel, M.J., Topciu, R.A., Franus, N., Talbot, N.L., & Duberstein, P.R. (2010). Association of alexithymia and depression symptom severity in adults aged 50 years and older. American Journal of Geriatric Psychiatry, 18, 51–56. doi:10.1097/JGP.0b013e3181bd1bfeGoogle Scholar
Bar-On, R., Brown, J.M., Kircaldy, B.D., & Thomé, E.P. (2000). Emotional expression and implications for occupational stress: An application of the Emotional Quotient Inventory. Personality and Individual Differences, 28, 1107–1118. doi:10.1016/S0191-8869(99)00160-9Google Scholar
Brackett, M.A., & Mayer, J.D. (2003). Convergent, discriminant and incremental validity of competing measures of emotional intelligence. Personality and Social Psychology Bulletin, 29, 1147–1158. doi:10.1177/0146167203254596Google Scholar
Bruder, G., Keilp, J., Xu, H., Shikman, M., Schori, E., Gorman, J., & Gilliam, T.C. (2005). Catechol-O-methyltransferase (COMT) genotypes and working memory: Associations with differing cognitive operations. Biological Psychiatry, 58, 901–907. doi:10.1016/j.biopsych.2005.05.010Google Scholar
Brummett, B.H., Boyle, S.H., Siegler, I.C., Kuhn, C.M., Ashley-Koch, A., Jonassaint, C.R., … Williams, R.B. (2008). Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behavior Genetics, 38, 34–43. doi:10.1007/s10519-007-9172-1Google Scholar
Canli, T., Ferri, J., & Duman, E.A. (2009). Genetics of emotion regulation. Neuroscience, 164, 43–54., doi:10.1016/j.neuroscience.2009.06.049CrossRefGoogle ScholarPubMed
Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389. doi:10.1126/science.1083968Google Scholar
Chen, J., Lipska, B.K., Halim, M., Ma, Q.D., Matsumoto, M., Melhem, S., … Weinberger, D.R. (2004). Functional analysis of genetic variation in catechol-O-metyltranserase (COMT): Effects on mRNA, protein, and enzyme activity in post mortem human brain. The American Journal of Human Genetics, 75, 807–821. doi:10.1086/425589CrossRefGoogle Scholar
Chiao, J.Y., & Blizinsky, K.D. (2010). Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene (5-HTTLPR). Proceedings of the Royal Society B: Biological Sciences, 277, 529–537. doi:10.1098/rspb.2009.1650Google Scholar
Chida, Y., & Hamer, M. (2008). Chronic psychosocial factors and acute physiological responses to laboratory-induced stress in healthy populations: A quantitative review of 30 years of investigations. Psychological Bulletin, 134, 829–885. doi:10.1037/a0013342CrossRefGoogle ScholarPubMed
Dawda, D., & Hart, S.D. (2000). Assessing emotional intelligence: Reliability and validity of the Bar-On Emotional Quotient Inventory (EQ-i) in university students. Personality and Individual Differences, 28, 797–812. doi:10.1016/S0191-8869(99)00139-7Google Scholar
Day, A.L., & Carroll, S.A. (2004). Using an ability-based measure of emotional intelligence to predict individual performance, group performance, and group citizenship behaviours. Personality and Individual Differences, 36, 1443–1458. doi:10.1016/S0191-8869(03)00240-XGoogle Scholar
de Frias, C.M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., & Nilsson, L.G. (2004). COMT gene polymorphism is associated with declarative memory in adulthood and old age. Behavior Genetics, 34, 533–539. doi:10.1023/B:BEGE.0000038491.06972.8cCrossRefGoogle ScholarPubMed
Decety, J., & Sommerville, J.A. (2003). Shared representations between self and other: A social cognitive neuroscience view. Trends in Cognitive Sciences, 7, 527–533. doi:10.1016/j.tics.2003.10.004Google Scholar
Declerck, C.H., Boone, C., & De Brabander, B.D. (2006). On feeling in control: A biological theory for individual differences in control perception. Brain and Cognition, 62, 143–176. doi:10.1016/j.bandc.2006.04.004Google Scholar
Defrancesco, M., Niederstätter, H., Parson, W., Oberacher, H., Hinterhuber, H., Canazei, M., … Marksteiner, J. (2011). Influence of serotonin transporter genotype and Catechol-O-Methyltransferase Val158Met polymorphism on recognition of emotional faces. Journal of the International Neuropsychological Society, 17, 1014–1020. doi:10.1017/S135561771100097XCrossRefGoogle ScholarPubMed
DeYoung, C.G., & Clark, R. (2012). The gene in its natural habitat: The importance of gene-trait interactions. Developmental Psychopathology, 24(4), 1307–1318. doi:10.1017/S0954579412000727CrossRefGoogle ScholarPubMed
Diaz-Asper, C.M., Goldberg, T.E., Kolachana, B.S., Straub, R.E., Egan, M.F., & Weinberger, D.R. (2008). Genetic variation in catechol-O-metyltransferase: Effects on working memory in schizophrenic patients, their siblings, and healthy controls. Biological Psychiatry, 63, 72–79. doi:10.1016/j.biopsych.2007.03.031Google Scholar
Drabant, E.M., Hariri, A.R., Meyer-Lindenberg, A., Munoz, K.E., Mattay, V.S., Kolachana, B.S., … Weinberger, D.R. (2006). Catechol-O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. Archives of General Psychiatry, 63, 1396–1406. doi:10.1001/archpsyc.63.12.1396CrossRefGoogle ScholarPubMed
Ducci, F., & Goldman, D. (2008). Genetic approaches to addiction: Genes and alcohol. Addiction, 103, 1414–1428. doi:10.1111/j.1360-0443.2008.02203.xCrossRefGoogle ScholarPubMed
Enoch, M.-A., Schuckit, M.A., Johnson, B.A., & Goldman, D. (2003). Genetics of alcoholism using intermediate phenotypes. Alcoholism: Clinical and Experimental Research, 27, 169–176. doi:10.1097/01.ALC.0000052702.77807.8CCrossRefGoogle ScholarPubMed
Extremera, N., Durán, A., & Rey, L. (2007). Perceived emotional intelligence and dispositional optimism-pessimism: Analyzing their role in predicting psychological adjustment among adolescents. Personality and Individual Differences, 42, 1069–1079. doi:10.1016/j.paid.2006.09.014Google Scholar
Freudenthaler, H.H., & Neubauer, A.C. (2005). Emotional intelligence: The convergent and discriminant validities of intra- and interpersonal emotional abilities. Personality and Individual Differences, 39, 569–579. doi:10.1016/j.paid.2005.02.004Google Scholar
Freudenthaler, H.H., Neubauer, A.C., & Haller, U. (2008). Emotional intelligence: Instruction effects and sex differences in emotional management abilities. Journal of Individual Differences, 29, 105–115. doi:10.1027/1614-0001.29.2.105Google Scholar
Freudenthaler, H.H., & Papousek, I. (2013). The typical and maximum performance of intra- and interpersonal emotion management. In C. Mohiyeddini (Ed.), Emotional relationships: Types, challenges, and physical/mental health impacts. Hauppauge, NY: Nova Science Publishers.Google Scholar
Gohm, C.L. (2004). Moving forward with emotional intelligence. Psychological Inquiry, 15, 222–227. 10.1207/s15327965pli1503_03Google Scholar
Goldberg, T.E., Egan, M.F., Gscheidle, T., Coppola, R., Weickert, T., Kolachana, B.S., … Weinberger, D.R. (2003). Executive subprocesses in working memory: Relationship to catechol-O-methyltransferase Val168Met genotype and schizophrenia. Archives of General Psychiatry, 60, 889–896. doi:10.1001/archpsyc.60.9.889Google Scholar
Grossmann, T., Johnson, M.H., Vaish, A., Hughes, D.A., Quinque, D., Stoneking, M., & Friederici, A.D. (2011). Genetic and neural dissociation of individual responses to emotional expressions in human infants. Developmental Cognitive Neuroscience, 1, 57–66. doi:10.1016/j.dcn.2010.07.001Google Scholar
Gyurak, A., Haase, C.M., Sze, J., Goodkind, M.S., Coppola, G., Lane, J., & Miller, B.L. (2013). The effect of the serotonin transporter polymorphism (5-HTTLPR) on empathic and self-conscious emotional reactivity. Emotion, 13, 25–35. doi:10.1037/a0029616Google Scholar
Harrison, P.J., & Tunbridge, E.M. (2008). Catechol-O-methyltransferase (COMT): A gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology, 33, 3037–3045. doi:10.1038/sj.npp.1301543Google Scholar
Hennings, A., Zill, P., & Rief, W. (2009). Serotonin transporter gene promoter polymorphism and somatoform symptoms. Journal of Clinical Psychiatry, 70, 1536–1539. doi:10.4088/JCP.08m04613Google Scholar
Homberg, J.R., & Lesch, K.P. (2011). Looking on the bright side of serotonin transporter gene variation. Biological Psychiatry, 69, 513–519. doi:10.1016/j.biopsych.2010.09.024Google Scholar
Hu, X., Oroszi, G., Chun, J., Smith, T.L., Goldman, D., & Schuckit, M.A. (2005). An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcoholism, Clinical and Experimental Research, 29, 8–16. doi:10.1097/01.ALC.0000150008.68473.62Google Scholar
Hu, X.Z., Lipsky, R.H., Zhu, G., Akhtar, L.A., Taubman, J., Greenberg, B.D., & Goldman, D. (2006). Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. American Journal of Human Genetics, 78, 815–826. doi:10.1086/503850Google Scholar
Jonassen, R., Foss Haug, K.B., Endestad, T., Bentsen, H., Grimholt, R.M., & Landro, N.I. (2013). Associations between serotonin transporter polymorphisms and cognitive processing applying the Emo 1-back task. Cognition and Emotion, 27, 465–473. doi:10.1080/02699931.2012.726213Google Scholar
Kano, M., Mizuno, T., Kawano, Y., Aoki, M., Kanazawa, M., & Fukudo, S. (2012). Serotonin transporter gene promoter polymorphism and alexithymia. Neuropsychobiology, 65, 76–82. doi:10.1159/000329554Google Scholar
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression metaanalysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444–454. doi:10.1001/archgenpsychiatry.2010.189CrossRefGoogle ScholarPubMed
Key, B.L., Campbell, T.S., Bacon, S.L., & Gerin, W. (2008). The influence of trait and state rumination on cardiovascular recovery from a negative emotional stressor. Journal of Behavioral Medicine, 31, 237–248. doi:10.1007/s10865-008-9152-9Google Scholar
Kim, S.J., Kang, J.I., Namkoong, K., & Song, D.H. (2011). The effects of serotonin transporter promoter and monoamine oxidase A gene polymorphisms on trait emotional intelligence. Neuropsychobiology, 64, 224–230. doi:10.1159/000327705Google Scholar
Kohler, C.G., Hoffman, L.J., Eastman, L.B., Healey, K., & Moberg, P.J. (2011). Facial emotion perception in depression and bipolar disorder: A quantitative review. Psychiatry Research, 188, 303–309. doi:10.1016/j.psychres.2011.04.019Google Scholar
Kohler, C.G., Walker, J.B., Martin, E.A., Healy, K.M., & Moberg, P.J. (2010). Facial emotion perception in schizophrenia: A meta-analytic review. Schizophrenia Bulletin, 36, 1009–1019. doi:10.1093/schbul/sbn192Google Scholar
Lachman, H.M., Papolos, D.F., Saito, T., Yu, Y.M., Szumlanski, C.L., & Weinshilboum, R.M. (1996). Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6, 243–250. doi:10.1097/00008571-199606000-00007Google Scholar
Mier, D., Kirsch, P., & Meyer-Lindenberg, A. (2009). Neural substrates of pleiotropic action of genetic variation in COMT: A meta-analysis. Molecular Psychiatry, 15(9), 918–927. doi:10.1038/mp.2009.36CrossRefGoogle ScholarPubMed
Mikolajczak, M., Luminet, O., Leroy, C., & Roy, E. (2007). Psychometric properties of the Trait Emotional Intelligence Questionnaire: Factor structure, reliability, construct, and incremental validity in a French-speaking population. Journal of Personality Assessment, 88, 338–353. doi:10.1080/00223890701333431Google Scholar
Mikolajczak, M., Nelis, D., Hansenne, M., & Quoidbach, J. (2008). If you can regulate sadness, you can probably regulate shame: Associations between trait emotional intelligence, emotion regulation and coping efficiency across discrete emotions. Personality and Individual Differences, 44, 1356–1368. doi:10.1016/j.paid.2007.12.004Google Scholar
Minelli, A., Bonvicini, C., Scassellati, C., Sartori, R., & Gennarelli, M. (2011). The influence of psychiatric screening in healthy populations selection: A new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits. BMC Psychiatry, 31, 11–50.Google Scholar
Mizuno, T., Aoki, M., Shimada, Y., Inoue, M., Nakaya, K., Takahashi, T., … Fukudo, S. (2006). Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety. Journal of Psychosomatic Research, 60, 91–97. doi:10.1016/j.jpsychores.2005.06.068Google Scholar
Montag, C., Buckholtz, J.W., Hartmann, P., Merz, M., Burk, C., Hennig, J., & Reuter, M. (2008). COMT genetic variation affects fear processing: Psychophysiological evidence. Behavioral Neuroscience, 122, 901–909. doi:10.1037/0735-7044.122.4.901Google Scholar
Murphy, S. E, Norbury, R., Godlewska, B.R., Cowen, P.J., Mannie, Z.M., Harmer, C.J., & Munafò, M.R. (2013). The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: A meta-analysis. Molecular Psychiatry, 18, 512–520. doi:10.1038/mp.2012.19Google Scholar
Naudts, K.H., Azevedo, R.T., David, A.S., van Heeringen, C., & Gibbs, A.A. (2012). Influence of COMT val158met and ADRA2B deletion polymorphisms on recollection and familiarity components of human emotional memory. Journal of Psychopharmacology, 26, 819–829. doi:10.1177/0269881111416688Google Scholar
Oberacher, H., Pitterl, F., Niederstätter, H., Weiss, E.M., Stadelmann, E., Marksteiner, J., & Parson, W. (2006). Direct molecular haplotyping of multiple polymorphisms within exon 4 of the human catechol-O-methyltransferase gene by liquid chromatography–electrospray ionization time-of-flight mass spectrometry. Analytical and Bioanalytical Chemistry, 386, 83–91. doi:10.1007/s00216-006-0589-9Google Scholar
Papousek, I., Freudenthaler, H.H., & Schulter, G. (2008). The interplay of perceiving and regulating emotions in becoming infected with positive and negative moods. Personality and Individual Differences, 45, 463–467. doi:10.1016/j.paid.2008.05.021Google Scholar
Papousek, I., Freudenthaler, H.H., & Schulter, G. (2011). Typical performance measures of emotion regulation and emotion perception and frontal EEG asymmetry in an emotional contagion paradigm. Personality and Individual Differences, 51, 1018–1022. doi:10.1016/j.paid.2011.08.013CrossRefGoogle Scholar
Papousek, I., Reiser, E.M., Schulter, G., Fink, A., Holmes, E.A., Niederstätter, H., & Weiss, E.M. (2013). Serotonin transporter genotype (5-HTTLPR) and electrocortical responses indicating the sensitivity to negative emotional cues. Emotion, 13, 1173–1181. doi:10.1037/a0033997Google Scholar
Papousek, I., Ruch, W., Freudenthaler, H.H., Kogler, E., Lang, B., & Schulter, G. (2009). Gelotophobia, emotion-related skills and responses to the affective states of others. Personality and Individual Differences, 47, 58–63. doi:10.1016/j.paid.2009.01.047Google Scholar
Papousek, I., Weiss, E.M., Reiser, E.M., Schulter, G., Freudenthaler, H.H., & Lackner, H.K. (2013). Self-rated social-emotional perception and its neurophysiologic and cardiac correlates while viewing a film showing the suffering of other people. International Journal of Psychological Research, 6, 42–55.Google Scholar
Pezawas, L., Meyer-Lindenberg, A., Drabant, E.M., Verchinski, B.A., Munoz, K.E., Kolachana, B.S., & Weinberger, D.R. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience, 8, 828–834. doi:10.1038/nn1463Google Scholar
Poletti, S., Radaelli, D., Cavallaro, R., Bosia, M., Lorenzi, C., Pirovano, A., … Benedetti, F. (2013). Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia. Comprehensive Psychiatry, 54, 181–186. doi:10.1016/j.comppsych.2012.06.008Google Scholar
Qualter, P., Barlow, A., & Stylianou, M.S. (2011). Investigating the relationship between trait and ability emotional intelligence and theory of mind. British Journal of Developmental Psychology, 29, 437–454. doi:10.1348/026151010X502999Google Scholar
Reja, V., Kwok, A., Stone, G., Yang, L., Missel, A., Menzel, C., & Bassam, B. (2010). ScreenClust: Advanced statistical software for supervised and unsupervised high resolution melting (HRM) analysis. Methods, 50, 10–14. doi:10.1016/j.ymeth.2010.02.006Google Scholar
Saklofske, D.H., Austin, E.J., & Minski, P.S. (2003). Factor structure and validity of a trait emotional intelligence measure. Personality and Individual Differences, 34, 707–721. doi:10.1016/S0191-8869(02)00056-9Google Scholar
Seamans, J.K., & Yang, C.R. (2004). The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Progress in Neurobiology, 74, 1–58. doi:10.1016/j.pneurobio.2004.05.006Google Scholar
Sen, S., Burmeister, M., & Ghosh, D. (2004). Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 127 B, 85–89. doi:10.1002/ajmg.b.20158Google Scholar
Smolka, M.N., Buhler, M., Schumann, G., Klein, S., Hu, X.Z., Moayer, M., … Heinz, A. (2007). Gene-gene effects on central processing of aversive stimuli. Molecular Psychiatry, 12, 307–317. doi:10.1038/sj.mp.4001946Google Scholar
Soeiro-de-Souza, M.G., Bio, D.S., David, D.P., Rodrigues dos Santos, D. Jr., Kerr, D.S., Gattaz, W.F., … Moreno, R.A. (2012). COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes. Journal of Affective Disorders, 136, 370–376. doi:10.1016/j.jad.2011.11.021Google Scholar
Starr, J.M., Fox, H., Harris, S.E., Deary, I.J., & Whalley, L.J. (2007). COMT genotype and cognitive ability: A longitudinal aging study. Neuroscience Letters, 421, 57–61. doi:10.1016/j.neulet.2007.05.023Google Scholar
Stoltenberg, S.F., & Vandever, J.M. (2010). Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk. Neuropharmacology, 58, 423–428. doi:10.1016/j.neuropharm.2009.09.010Google Scholar
Tunbridge, E.M., Harrison, P.J., & Weinberger, D.R. (2006). Catechol-O-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biological Psychiatry, 60, 141–151. doi:10.1016/j.biopsych.2005.10.024Google Scholar
Weiss, E.M., Schulter, G., Freudenthaler, H.H., Hofer, E., Pichler, N., & Papousek, I. (2012). Potential markers of aggressive behavior: The fear of other persons’ laughter and its overlaps with mental disorders. PLoS One, 7, e38088. doi:10.1371/journal.pone.0038088Google Scholar
Weiss, E.M., Stadelmann, E., Kohler, C.G., Brensinger, C.M., Nolan, K.A., Oberacher, H., … Marksteiner, J. (2007). Differential effect of catechol-O-methyltransferase Val158Met genotype on emotional recognition abilities in healthy men and women. Journal of the International Neuropsychological Society, 13, 881–887. doi:10.1017/S1355617707070932Google Scholar
Zubieta, J.-K., Heitzeg, M.M., Smith, Y.R., Bueller, J.A., Xu, K., Xu, Y., … Goldman, D. (2003). COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science, 299, 1240–1243. doi:10.1126/science.1078546Google Scholar