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Characterizing the Normal Developmental Trajectory of Expressive Language Lateralization Using Magnetoencephalography

Published online by Cambridge University Press:  04 August 2011

Darren S. Kadis ,
Elizabeth W. Pang ,
Travis Mills ,
Margot J. Taylor ,
Mary Pat McAndrews  and
Mary Lou Smith
Darren S. Kadis
Affiliation:
Division of Neurology, Hospital for Sick Children, Toronto, Ontario Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario
Elizabeth W. Pang
Affiliation:
Division of Neurology, Hospital for Sick Children, Toronto, Ontario Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario Department of Paediatrics, Division of Neurology, University of Toronto, Toronto, Ontario
Travis Mills
Affiliation:
Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario
Margot J. Taylor
Affiliation:
Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario Department of Psychology, University of Toronto, Toronto, Ontario
Mary Pat McAndrews
Affiliation:
Department of Psychology, University of Toronto, Toronto, Ontario Brain Imaging & Behaviour Systems, Toronto Western Research Institute, Toronto, Ontario
Mary Lou Smith*
Affiliation:
Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario Department of Psychology, University of Toronto, Toronto, Ontario Department of Psychology, Hospital for Sick Children, Toronto, Ontario
*
Correspondence and reprint requests to: Mary Lou Smith, Department of Psychology, University of Toronto Mississauga, 3359 Mississauga Road, North, Mississauga, ON L5L 1C6 Canada. E-mail: marylou.smith@utoronto.ca
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Abstract

To characterize the developmental trajectory for expressive language representation and to test competing explanations for the relative neuroplasticity of language in childhood, we studied 28 healthy children and adolescents (aged 5–19 years) participating in a covert verb generation task in magnetoencephalography. Lateralization of neuromagnetic responses in the frontal lobe was quantified using a bootstrap statistical thresholding procedure for differential beamformer analyses. We observed a significant positive correlation between left hemisphere lateralization and age. Findings suggest that adult-typical left hemisphere lateralization emerges from an early bilateral language network, which may explain the pediatric advantage for interhemispheric plasticity of language. (JINS, 2011, 17, 896–904)

Keywords

Neuronal plasticityBroca areaChildBeamformerSynthetic aperture magnetometry
Type
Regular Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 5 , September 2011 , pp. 896 - 904
Copyright
Copyright © The International Neuropsychological Society 2011

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