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White Matter Microstructural Integrity and Executive Function in Parkinson's Disease

Published online by Cambridge University Press:  15 January 2013

Catherine Gallagher*
Affiliation:
William S. Middleton Memorial VA Hospital, Madison, Wisconsin Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Brian Bell
Affiliation:
William S. Middleton Memorial VA Hospital, Madison, Wisconsin Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Barbara Bendlin
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Matthew Palotti
Affiliation:
William S. Middleton Memorial VA Hospital, Madison, Wisconsin Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Ozioma Okonkwo
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Aparna Sodhi
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Rachel Wong
Affiliation:
William S. Middleton Memorial VA Hospital, Madison, Wisconsin Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Laura Buyan-Dent
Affiliation:
Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Sterling Johnson
Affiliation:
William S. Middleton Memorial VA Hospital, Madison, Wisconsin Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Auriel Wilette
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Sandra Harding
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Nancy Ninman
Affiliation:
Department of Neurology, University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, Wisconsin
Erik Kastman
Affiliation:
Department of Medicine and Alzheimer's Disease Research Center, UWSMPH, Madison, Wisconsin
Andrew Alexander
Affiliation:
Waisman Center Laboratory for Brain Imaging and Behavior, Madison, Wisconsin Department of Medical Physics, UWSMPH, Madison, Wisconsin
*
Correspondence and reprint requests to: Catherine Gallagher, 7211 MFCB, 1685 Highland Avenue, Madison, WI 53705-2281. E-mail: gallagher@neurology.wisc.edu

Abstract

Recent studies suggest that white matter abnormalities contribute to both motor and non-motor symptoms of Parkinson's disease. The present study was designed to investigate the degree to which diffusion tensor magnetic resonance imaging (DTI) indices are related to executive function in Parkinson's patients. We used tract-based spatial statistics to compare DTI data from 15 patients to 15 healthy, age- and education-matched controls. We then extracted mean values of fractional anisotropy (FA) and mean diffusivity (MD) within an a priori frontal mask. Executive function composite Z scores were regressed against these DTI indices, age, and total intracranial volume. In Parkinson's patients, FA was related to executive composite scores, and both indices were related to Stroop interference scores. We conclude that white matter microstructural abnormalities contribute to cognitive deficits in Parkinson's disease. Further work is needed to determine whether these white matter changes reflect the pathological process or a clinically important comorbidity. (JINS, 2013, 19, 1–6)

Type
Brief Communication
Copyright
Copyright © The International Neuropsychological Society 2013

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