Skip to main content Accessibility help
×
Home
Hostname: page-component-78bd46657c-5628d Total loading time: 0.282 Render date: 2021-05-07T16:42:41.828Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": false, "newCiteModal": false, "newCitedByModal": true }

PTSD Modifies Performance on a Task of Affective Executive Control among Deployed OEF/OIF Veterans with Mild Traumatic Brain Injury

Published online by Cambridge University Press:  03 July 2013

Melissa M. Amick
Affiliation:
Translational Research Center for Traumatic Brain Injury and Stress Disorders, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Boston University Medical School, Boston, Massachusetts
Alexandra Clark
Affiliation:
Translational Research Center for Traumatic Brain Injury and Stress Disorders, VA Boston Healthcare System, Boston, Massachusetts
Catherine B. Fortier
Affiliation:
Translational Research Center for Traumatic Brain Injury and Stress Disorders, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Harvard Medical School Boston, Massachusetts
Michael Esterman
Affiliation:
Translational Research Center for Traumatic Brain Injury and Stress Disorders, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Boston University Medical School, Boston, Massachusetts
Ann M. Rasmusson
Affiliation:
Translational Research Center for Traumatic Brain Injury and Stress Disorders, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Boston University Medical School, Boston, Massachusetts
Alexandra Kenna
Affiliation:
Translational Research Center for Traumatic Brain Injury and Stress Disorders, VA Boston Healthcare System, Boston, Massachusetts
William P. Milberg
Affiliation:
Translational Research Center for Traumatic Brain Injury and Stress Disorders, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Harvard Medical School Boston, Massachusetts Geriatric Research, Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts
Regina McGlinchey
Affiliation:
Translational Research Center for Traumatic Brain Injury and Stress Disorders, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Harvard Medical School Boston, Massachusetts Geriatric Research, Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts
Corresponding
E-mail address:

Abstract

Individuals with post-traumatic stress disorder (PTSD) show a cognitive bias for threatening information, reflecting dysregulated executive control for affective stimuli. This study examined whether comorbid mild Traumatic Brain Injury (mTBI) with PTSD exacerbates this bias. A computer-administered Affective Go/No-Go task measured reaction times (RTs) and errors of omission and commission to words with a non–combat-related positive or negative valence in 72 deployed United States service members from the wars in Iraq and Afghanistan. Incidents of military-related mTBI were measured with the Boston Assessment of Traumatic Brain Injury-Lifetime. PTSD symptoms were measured with the Clinician-Administered PTSD Scale. Participants were divided into those with (mTBI+, n = 34) and without a history of military-related mTBI (mTBI−, n = 38). Valence of the target stimuli differentially impacted errors of commission and decision bias (criterion) in the mTBI+ and mTBI− groups. Specifically, within the mTBI+ group, increasing severity of PTSD symptoms was associated with an increasingly liberal response pattern (defined as more commission errors to negative distractors and greater hit rate for positive stimuli) in the positive compared to the negative blocks. This association was not observed in the mTBI− group. This study underscores the importance of considering the impact of a military-related mTBI and PTSD severity upon affective executive control. (JINS, 2013, 19, 1–10)

Type
Research Articles
Copyright
Copyright © The International Neuropsychological Society 2013 

Access options

Get access to the full version of this content by using one of the access options below.

References

Amir, N., Beard, C., Taylor, C.T., Klumpp, H., Elias, J., Burns, M., Chen, X. (2009). Attention training in individuals with generalized social phobia: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 77(5), 961973.CrossRefGoogle ScholarPubMed
Atkinson, M.P., Guetz, A., Wein, L.M. (2009). A dynamic model for post traumatic stress disorder among US troops in Operation Iraqi Freedom. Management Science, 55(9), 14541468.CrossRefGoogle Scholar
Aupperle, R.L., Allard, C.B., Grimes, E.M., Simmons, A.N., Flagan, T., Behrooznia, M., Stein, M.B. (2012). Dorsolateral prefrontal cortex activation during emotional anticipation and neuropsychological performance in posttraumatic stress disorder. Archives of General Psychiatry, 69(4), 360371.Google ScholarPubMed
Aupperle, R.L., Melrose, A.J., Stein, M.B., Paulus, M.P. (2012). Executive function and PTSD: Disengaging from trauma. Neuropharmacology, 62(2), 686694.CrossRefGoogle ScholarPubMed
Belanger, H.G., Kretzmer, T., Vanderploeg, R.D., French, L.M. (2010). Symptom complaints following combat-related traumatic brain injury: Relationship to traumatic brain injury severity and posttraumatic stress disorder. Journal of International Neuropsychological Society, 16(1), 194199.CrossRefGoogle ScholarPubMed
Bigler, E.D. (2004). Neuropsychological results and neuropathological findings at autopsy in a case of mild traumatic brain injury. Journal of International Neuropsychological Society, 10(5), 794806.CrossRefGoogle Scholar
Blake, D.D., Weathers, F.W., Nagy, L.M. (1993). A clinician rating scale for assessing current and lifetime PTSD: the CAPS-I. Behavior Therapy, 18, 187188.Google Scholar
Blake, D.D., Weathers, F.W., Nagy, L.M., Kaloupek, D.G., Gusman, F.D., Charney, D.S., Keane, T.M. (1995). The development of a clinician-administered PTSD Scale. Journal of Traumatic Stress, 8(1), 7590.CrossRefGoogle ScholarPubMed
Brenner, L.A., Vanderploeg, R.D., Terrio, H. (2009). Assessment and diagnosis of mild traumatic brain injury, posttraumatic stress disorder, and other polytrauma conditions: Burden of adversity hypothesis. Rehabilitation Psychology, 54(3), 239246.CrossRefGoogle ScholarPubMed
Brewin, C.R., Kleiner, J.S., Vasterling, J.J., Field, A.P. (2007). Memory for emotionally neutral information in posttraumatic stress disorder: A meta-analytic investigation, 116(3), 448463.Google ScholarPubMed
Bryant, R. (2011). Post-traumatic stress disorder vs traumatic brain injury. Dialogues Clinical Neuroscience, 13(3), 251262.Google ScholarPubMed
Bryant, R.A., Harvey, A.G. (1997). Acute stress disorder: A critical review of diagnostic issues. Clinical Psychology Review, 17(7), 757773.CrossRefGoogle ScholarPubMed
Buckley, T.C., Blanchard, E.B., Neill, W.T. (2000). Information processing and PTSD: A review of the empirical literature. Clinical Psychology Review, 20(8), 10411065.CrossRefGoogle ScholarPubMed
Calhoun, P.S., McDonald, S.D., Guerra, V.S., Eggleston, A.M., Beckham, J.C., Straits-Troster, K. (2010). Clinical utility of the Primary Care--PTSD Screen among U.S. veterans who served since September 11, 2001. Psychiatry Research, 178(2), 330335.CrossRefGoogle ScholarPubMed
Carroll, L.J., Cassidy, J.D., Peloso, P.M., Borg, J., von Holst, H., Holm, L., Pépin, M. (2004). Prognosis for mild traumatic brain injury: Results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. Journal of Rehabiliation Medicine, 43(Suppl), 84105.CrossRefGoogle Scholar
Chemtob, C.M., Muraoka, M.Y., Wu-Holt, P., Fairbank, J.A., Hamada, R.S., Keane, T.M. (1998). Head injury and combat-related posttraumatic stress disorder. The Journal of Nervous & Mental Disease, 186(11), 701708.CrossRefGoogle ScholarPubMed
Cisler, J.M., Olatunji, B.O., Feldner, M.T., Forsyth, J.P. (2010). Emotion regulation and the anxiety disorders: An integrative review. Journal of Psychopathoology & Behavioral Assessment, 32(1), 6882.CrossRefGoogle ScholarPubMed
Constans, J.I. (2005). Information-processing biases in PTSD. In J.J. Vasterling (Ed.), Neuropsychology of PTSD: Biological, cognitive and clinical perspectives (pp. 105130). New York: Guildford Press.Google Scholar
Constans, J.I., McCloskey, M.S., Vasterling, J.J., Brailey, K., Mathews, A. (2004). Suppression of attentional bias in PTSD. Journal of Abnormal Psychology, 113(2), 315323.CrossRefGoogle ScholarPubMed
Crawford, M.A., Knight, R.G., Alsop, B.L. (2007). Speed of word retrieval in postconcussion syndrome. Journal of International Neuropsychological Society, 13(1), 178182.CrossRefGoogle ScholarPubMed
De Monte, V.E., Geffen, G.M., May, C.R., McFarland, K., Heath, P., Neralic, M. (2005). The acute effects of mild traumatic brain injury on finger tapping with and without word repetition. Journal of Clinical & Experimental Neuropsychology, 27(2), 224239.CrossRefGoogle ScholarPubMed
DeGutis, J., D'Esposito, M. (2009). Network changes in the transition from initial learning to well-practiced visual categorization. Frontiers of Human Neuroscience, 3, 44.CrossRefGoogle ScholarPubMed
DeGutis, J., Van Vleet, T.M. (2010). Tonic and phasic alertness training: A novel behavioral therapy to improve spatial non-spatial attention in patients with hemispatial neglect. Frontiers in Human Neuroscience, 4, 60.CrossRefGoogle ScholarPubMed
Eldar, S., Bar-Haim, Y. (2010). Neural plasticity in response to attention training in anxiety. Psychological Medicine, 40(4), 667677.CrossRefGoogle ScholarPubMed
Esterman, M., Noonan, S.K., Rosenberg, M., Degutis, J. (2012). In the zone or zoning out? Tracking behavioral and neural fluctuations during sustained attention. Cerebral Cortex, [Epub ahead of print].Google ScholarPubMed
Falconer, E., Bryant, R., Felmingham, K.L., Kemp, A.H., Gordon, E., Peduto, A., Williams, L.M. (2008). The neural networks of inhibitory control in posttraumatic stress disorder. Journal of Psychiatric Neuroscience, 33(5), 413422.Google ScholarPubMed
Fortier, C.B., Amick, M.M., Grande, L., McGlynn, S., Kenna, A., Morra, L., McGlinchey, R.M. (2013). The Boston Assessment of Traumatic Brain Injury-Lifetime (BAT-L) semistructured interview: Evidence of research utility and validity. Journal of Head Trauma Rehabilitation, [Epub ahead of print].Google Scholar
Green, P. (2003). Green's Medical Symptom Validity Test (MSVT) for Windows: User's manual. Edmonton, Canada: Green's Publishing.Google Scholar
Harvey, A.G., Bryant, R.A. (2000). Two-year prospective evaluation of the relationship between acute stress disorder and posttraumatic stress disorder following mild traumatic brain injury. American Journal of Psychiatry, 157(4), 626628.CrossRefGoogle ScholarPubMed
Hill, J.J. III, Mobo, B.H. Jr., Cullen, M.R. (2009). Separating deployment-related traumatic brain injury and posttraumatic stress disorder in veterans: Preliminary findings from the Veterans Affairs traumatic brain injury screening program. American Journal of Physical Medicine and Rehabilitation, 88(8), 605614.CrossRefGoogle ScholarPubMed
Hoge, C.W., Castro, C.A., Messer, S.C., McGurk, D., Cotting, D.I., Koffman, R.L. (2004). Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care. New England Journal of Medicine, 351(1), 1322.CrossRefGoogle ScholarPubMed
Hoge, C.W., McGurk, D., Thomas, J.L., Cox, A.L., Engel, C.C., Castro, C.A. (2008). Mild traumatic brain injury in U.S. Soldiers returning from Iraq. New England Journal of Medicine, 358(5), 453463.CrossRefGoogle ScholarPubMed
Huang, M.X., Theilmann, R.J., Robb, A., Angeles, A., Nichols, S., Drake, A., Lee, R.R. (2009). Integrated imaging approach with MEG and DTI to detect mild traumatic brain injury in military and civilian patients. Journal of Neurotrauma, 26(8), 12131226.CrossRefGoogle ScholarPubMed
Iverson, G.L. (2005). Outcome from mild traumatic brain injury. Current Opinion in Psychiatry, 18(3), 301317.CrossRefGoogle ScholarPubMed
Kimble, M.O., Fleming, K., Bandy, C., Kim, J., Zambetti, A. (2010). Eye tracking and visual attention to threating stimuli in veterans of the Iraq war. Journal of Anxiety Disorders, 24(3), 293299.CrossRefGoogle ScholarPubMed
King, D.W., King, L.A., Vogt, D.S., Knight, J., Samper, R. (2006). Deployment Risk and Resilience Inventory: A collection of measures for studying deployment -related experiences of military personnel and veterans. Military Psychology, 18(2), 89120.CrossRefGoogle Scholar
Lo, C., Shifteh, K., Gold, T., Bello, J.A., Lipton, M.L. (2009). Diffusion tensor imaging abnormalities in patients with mild traumatic brain injury and neurocognitive impairment. Journal of Computer Assisted Tomography, 33(2), 293297.CrossRefGoogle ScholarPubMed
Mac Donald, C.L., Johnson, A.M., Cooper, D., Nelson, E.C., Werner, N.J., Shimony, J.S., Brody, D.L. (2011). Detection of blast-related traumatic brain injury in U. S. military personnel. New England Journal of Medicine, 364(22), 20912100.CrossRefGoogle ScholarPubMed
Mayer, A.R., Mannell, M.V., Ling, J., Elgie, R., Gasparovic, C., Phillips, J.P., Yeo, R.A. (2009). Auditory orienting and inhibition of return in mild traumatic brain injury: A FMRI study. Human Brain Mapping, 30(12), 41524166.CrossRefGoogle ScholarPubMed
McAllister, T.W. (2009). Psychopharmacological issues in the treatment of TBI and PTSD. The Clinical Neuropsychologist, 23(8), 13381367.CrossRefGoogle ScholarPubMed
Pannu Hayes, J., Labar, K.S., Petty, C.M., McCarthy, G., Morey, R.A. (2009). Alterations in the neural circuitry for emotion and attention associated with posttraumatic stress symptomatology. Psychiatry Research, 172(1), 715.CrossRefGoogle ScholarPubMed
Pineles, S.L., Shipherd, J.C., Mostoufi, S.M., Abramovitz, S.M., Yovel, I. (2009). Attentional biases in PTSD: More evidence for interference. Behavior Research and Therapy, 47(12), 10501057.CrossRefGoogle ScholarPubMed
Pontifex, M.B., O'Connor, P.M., Broglio, S.P., Hillman, C.H. (2009). The association between mild traumatic brain injury history and cognitive control. Neuropsychologia, 47(14), 32103216.CrossRefGoogle ScholarPubMed
Pitman, R.K., Rasmusson, A.M., Koenen, K.C., Shin, L.M., Orr, S.P., Gilbertson, M.W., Liberzon, I. (2012). Biological studies of post-traumatic stress disorder. Nature Reviews Neuroscience, 13(11), 769787.CrossRefGoogle ScholarPubMed
Reger, M.L., Poulos, A.M., Buen, F., Giza, C.C., Hovda, D.A., Fanselow, M.S. (2012). Concussive brain injury enhances fear learning and excitatory processes in the amygdala. Biological Psychiatry, 71(4), 335343.CrossRefGoogle ScholarPubMed
Robbins, T.W., James, M., Owen, A.M., Sahakian, B.J., Lawrence, A.D., McInnes, L., Rabbit, P.M. (1998). A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: Implications for theories of executive functioning and cognitive aging. Cambridge Neuropsychological Test Automated Battery. Journal of International Neuropsychological Society, 4(5), 474490.CrossRefGoogle Scholar
Robbins, T.W., James, M., Owen, A.M., Sahakian, B.J., McInnes, L., Rabbitt, P. (1994). Cambridge Neuropsychological Test Automated Battery (CANTAB): A factor analytic study of a large sample of normal elderly volunteers. Dementia, 5(5), 266281.Google ScholarPubMed
Schneiderman, A.I., Braver, E.R., Kang, H.K. (2008). Understanding sequelae of injury mechanisms and mild traumatic brain injury incurred during the conflicts in Iraq and Afghanistan: Persistent postconcussive symptoms and posttraumatic stress disorder. American Journal of Epidemiology, 167(12), 14461452.CrossRefGoogle ScholarPubMed
Sponheim, S.R., McGuire, K.A., Kang, S.S., Davenport, N.D., Aviyente, S., Bernat, E.M., Lim, K.O. (2011). Evidence of disrupted functional connectivity in the brain after combat-related blast injury. Neuroimage, 54(Suppl), S21S29.CrossRefGoogle ScholarPubMed
Stein, M.B., McAllister, T.W. (2009). Exploring the convergence of posttraumatic stress disorder and mild traumatic brain injury. American Journal of Psychiatry, 166(7), 768776.CrossRefGoogle ScholarPubMed
Swick, D., Honzel, N., Larsen, J., Ashley, V., Justus, T. (2012). Impaired response inhibition in veterans with post-traumatic stress disorder and mild traumatic brain injury. Journal of International Neuropsychological Society, 18(5), 917926.CrossRefGoogle ScholarPubMed
Terrio, H., Brenner, L.A., Ivins, B.J., Cho, J.M., Helmick, K., Schwab, K., Warden, D. (2009). Traumatic brain injury screening: Preliminary findings in a US Army brigade combat team. Journal of Head Trauma Rehabilitation, 24(1), 1423.CrossRefGoogle Scholar
Thrasher, S.M., Dalgleish, T., Yule, W. (1994). Information processing in post-traumatic stress disorder. Behavior Research Therapy, 32(2), 247254.CrossRefGoogle ScholarPubMed
Van Zomeren, A.H., Brouwer, W.H., Deelman, B.G. (1984). Attentional deficits: The riddles of selectivity, speed and alertness. Oxford: Oxford University Press.Google Scholar
Vanderploeg, R.D., Belanger, H.G., Curtiss, G. (2009). Mild traumatic brain injury and posttraumatic stress disorder and their associations with health symptoms. Archives of Physical Medicine and Rehabilitation, 90(7), 10841093.CrossRefGoogle ScholarPubMed
Vasterling, J.J., Proctor, S.P., Amoroso, P., Kane, R., Heeren, T., White, R.F. (2006). Neuropsychological outcomes of army personnel following deployment to the Iraq war. Journal of American Medical Association, 296(5), 519529.CrossRefGoogle ScholarPubMed
Vogt, D.S., Proctor, S.P., King, D.W., King, L.A., Vasterling, J.J. (2008). Validation of scales from the Deployment Risk and Resilience Inventory in a sample of Operation Iraqi Freedom veterans. Assessment, 15(4), 391403.CrossRefGoogle Scholar
Walilko, T., North, C., Young, L.A., Lux, W.E., Warden, D.L., Jaffee, M.S., Moore, D.F. (2009). Head injury as a PTSD predictor among Oklahoma City bombing survivors. Journal of Trauma, 67(6), 13111319.CrossRefGoogle ScholarPubMed

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

PTSD Modifies Performance on a Task of Affective Executive Control among Deployed OEF/OIF Veterans with Mild Traumatic Brain Injury
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

PTSD Modifies Performance on a Task of Affective Executive Control among Deployed OEF/OIF Veterans with Mild Traumatic Brain Injury
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

PTSD Modifies Performance on a Task of Affective Executive Control among Deployed OEF/OIF Veterans with Mild Traumatic Brain Injury
Available formats
×
×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *