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Influence of major antiepileptic drugs on neuropsychological function: Results from a randomized, double-blind, placebo-controlled withdrawal study of seizure-free epilepsy patients on monotherapy

Published online by Cambridge University Press:  20 March 2007

Helse Øst Health Services Research Centre, and Department of Neurology, Akershus University Hospital, Oslo, Norway
Helse Øst Health Services Research Centre, and Department of Neurology, Akershus University Hospital, Oslo, Norway National Center for Epilepsy, Rikshospitalet, University of Oslo, Oslo, Norway
Department of Psychology, University of Oslo, Oslo, Norway
Department of Neurology, Rikshospitalet and Faculty of Medicine, University of Oslo, Oslo, Norway


The aim of this study was to assess cognitive effects of anticonvulsants in a way that would yield results that are most directly applicable to epilepsy populations. This was done with a placebo-controlled, prospective, randomized, double-blind, parallel group study of anticonvulsant withdrawal in a population of subjects taking a single anticonvulsant with completely controlled seizures. Outcomes of this study on cognitive measures from the California Computerized Assessment Package have recently been reported. To aid comparison with results of prior studies, we report outcomes here on several more standard measures of neuropsychological function. The major findings were that, in subjects with therapeutic drug levels at baseline, drug withdrawal was associated with significant improvement in performance on the Controlled Oral Word Association Test and the Stroop Color–Word Interference Test. Comparable results were achieved in the subgroup taking carbamazepine. (JINS, 2007, 13, 393–400.)

Research Article
© 2007 The International Neuropsychological Society

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