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Functional neuroimaging studies of aging and emotion: Fronto-amygdalar differences during emotional perception and episodic memory

Published online by Cambridge University Press:  01 November 2009

PEGGY L. ST. JACQUES
Affiliation:
Center for Cognitive Neuroscience and Department of Psychology and Neuroscience, Duke University, Durham, North Carolina
BRANDY BESSETTE-SYMONS
Affiliation:
Center for Cognitive Neuroscience and Department of Psychology and Neuroscience, Duke University, Durham, North Carolina
ROBERTO CABEZA
Affiliation:
Center for Cognitive Neuroscience and Department of Psychology and Neuroscience, Duke University, Durham, North Carolina
Corresponding
E-mail address:

Abstract

Emotional processes are enhanced in aging, such that aging is characterized by superior emotional regulation. This article provides a brief review of the neural bases supporting this effect with a focus on functional neuroimaging studies of perception and episodic memory. The most consistent finding across these studies is that older adults show an alteration in the recruitment of the amygdala, but greater recruitment of the frontal cortex. These Fronto-amygdalar Age-related Differences in Emotion (FADE) may reflect emotional regulation strategies mediated by frontal brain regions that dampen emotion-related activations in the amygdala. (JINS, 2009, 15, 819–825.)

Type
Short Review
Copyright
Copyright © The International Neuropsychological Society 2009

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References

Amaral, D.G., & Price, J.L. (1984). Amygdalo-cortical projections in the monkey (Macaca fascicularis). The Journal of Comparative Neurology, 230, 465496.CrossRefGoogle Scholar
Amodio, D.M., & Frith, C.D. (2006). Meeting of minds: The medial frontal cortex and social cognition. Nature Reviews. Neuroscience, 7, 268277.CrossRefGoogle ScholarPubMed
Cabeza, R., & St Jacques, P. (2007). Functional neuroimaging of autobiographical memory. Trends in Cognitive Sciences, 11, 219227.CrossRefGoogle ScholarPubMed
Davis, S.W., Dennis, N.A., Daselaar, S.M., Fleck, M.S., & Cabeza, R. (2008). Que PASA? The posterior-anterior shift in aging. Cerebral Cortex, 18, 12011209.CrossRefGoogle Scholar
Dennis, N.A., & Cabeza, R. (2008). Neuroimaging of healthy cognitive aging. In Craik, F.I.M. & Salthouse, T.A. (Eds.), The handbook of aging and cognition (3rd ed., pp. 154). Mahwah, NJ: Lawrence Erlbaum Associates.Google Scholar
Dolcos, F., LaBar, K.S., & Cabeza, R. (2004). Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: An event-related fMRI study. Neuroimage, 23, 6474.CrossRefGoogle Scholar
Erk, S., Walter, H., & Abler, B. (2008). Age-related physiological responses to emotion anticipation and exposure. Neuroreport, 19, 447452.CrossRefGoogle ScholarPubMed
Fischer, H., Sandblom, J., Gavazzeni, J., Fransson, P., Wright, C.I., & Backman, L. (2005). Age-differential patterns of brain activation during perception of angry faces. Neuroscience Letters, 386, 99104.CrossRefGoogle ScholarPubMed
Good, C.D., Johnsrude, I.S., Ashburner, J., Henson, R.N., Friston, K.J., & Frackowiak, R.S. (2001). A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage, 14(Pt 1), 2136.CrossRefGoogle ScholarPubMed
Grady, C.L. (2008). Cognitive neuroscience of aging. Annals of the New York Academy of Sciences, 1124, 127144.CrossRefGoogle Scholar
Grady, C.L., Springer, M.V., Hongwanishkul, D., McIntosh, A.R., & Winocur, G. (2006). Age-related changes in brain activity across the adult lifespan. Journal of Cognitive Neurosciences, 18, 227241.CrossRefGoogle ScholarPubMed
Grieve, S.M., Clark, C.R., Williams, L.M., Peduto, A.J., & Gordon, E. (2005). Preservation of limbic and paralimbic structures in aging. Human Brain Mapping, 25, 391401.CrossRefGoogle Scholar
Gunning-Dixon, F.M., Gur, R.C., Perkins, A.C., Schroeder, L., Turner, T., Turetsky, B.I., et al. (2003). Age-related differences in brain activation during emotional face processing. Neurobiology of Aging, 24, 285295.CrossRefGoogle ScholarPubMed
Gusnard, D.A., Akbudak, E., Shulman, G.L., & Raichle, M.E. (2001). Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function. Proceedings of the National Academy of Science of the United States of America, 98, 42594264.CrossRefGoogle ScholarPubMed
Gutchess, A.H., Kensinger, E.A., & Schacter, D.L. (2007a). Aging, self-referencing, and medial prefrontal cortex. Social Neuroscience, 2, 117133.CrossRefGoogle ScholarPubMed
Gutchess, A.H., Kensinger, E.A., Yoon, C., & Schacter, D.L. (2007b). Ageing and the self-reference effect in memory. Memory, 15, 822837.CrossRefGoogle ScholarPubMed
Iidaka, T., Okada, T., Murata, T., Omori, M., Kosaka, H., Sadato, N., et al. (2002). Age-related differences in the medial temporal lobe responses to emotional faces as revealed by fMRI. Hippocampus, 12, 352362.CrossRefGoogle ScholarPubMed
Kensinger, E.A. (2008). Emotional memory across the adult lifespan. New York: Psychology Press.Google Scholar
Kensinger, E.A., & Leclerc, C.M. (2009). Age-related changes in the neural mechanisms supporting emotion processing and emotional memory. European Journal of Cognitive Psychology, 21, 192215.CrossRefGoogle Scholar
Kensinger, E.A., & Schacter, D.L. (2008). Neural processes supporting young and older adults’ emotional memories. Journal of Cognitive Neurosciences, 20, 11611173.CrossRefGoogle Scholar
LaBar, K.S., & Cabeza, R. (2006). Cognitive neuroscience of emotional memory. Nature Reviews. Neuroscience, 7, 5464.CrossRefGoogle ScholarPubMed
Lang, P.J., Bradley, M.M., & Cuthbert, B.N. (Producer). (1997) International affective picture system (IAPS). Gainesville, FL: University of Florida.Google Scholar
Leclerc, C.M., & Kensinger, E.A. (2008a). Age-related differences in medial prefrontal activation in response to emotional images. Cognitive, Affective & Behavioral Neuroscience, 8, 153164.CrossRefGoogle ScholarPubMed
Leclerc, C.M., & Kensinger, E.A. (2008b). Effects of age on detection of emotional information. Psychology and Aging, 23, 209215.CrossRefGoogle ScholarPubMed
Mather, M., Canli, T., English, T., Whitfield, S., Wais, P., Ochsner, K., et al. (2004). Amygdala responses to emotionally valenced stimuli in older and younger adults. Psychological Science, 15, 259263.CrossRefGoogle ScholarPubMed
Mather, M., & Carstensen, L.L. (2005). Aging and motivated cognition: The positivity effect in attention and memory. Trends in Cognitive Sciences, 9, 496502.CrossRefGoogle ScholarPubMed
Mayberg, H.S. (1997). Limbic-cortical dysregulation: A proposed model of depression. The Journal of Neuropsychiatry and Clinical Neurosciences, 9, 471481.Google Scholar
Miller, E.K., & Cohen, J.D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167202.CrossRefGoogle ScholarPubMed
Murty, V.P., Sambataro, F., Das, S., Tan, H., Callicott, J.H., Goldberg, T.E., et al. (2008). Age-related alterations in simple declarative memory and the effect of negative stimulus valence. Journal of Cognitive Neuroscience, [Epub ahead of print].Google Scholar
Northoff, G., & Bermpohl, F. (2004). Cortical midline structures and the self. Trends in Cognitive Sciences, 8, 102107.CrossRefGoogle ScholarPubMed
Ochsner, K.N., & Gross, J.J. (2005). The cognitive control of emotion. Trends in Cognitive Sciences, 9, 242249.CrossRefGoogle ScholarPubMed
Petit-Taboue, M.C., Landeau, B., Desson, J.F., Desgranges, B., & Baron, J.C. (1998). Effects of healthy aging on the regional cerebral metabolic rate of glucose assessed with statistical parametric mapping. Neuroimage, 7, 176184.CrossRefGoogle ScholarPubMed
Phan, K.L., Wager, T., Taylor, S.F., & Liberzon, I. (2002). Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI. Neuroimage, 16, 331348.CrossRefGoogle ScholarPubMed
Raz, N., Lindenberger, U., Rodrigue, K.M., Kennedy, K.M., Head, D., Williamson, A., et al. (2005). Regional brain changes in aging healthy adults: General trends, individual differences and modifiers. Cerebral Cortex, 15, 16761689.CrossRefGoogle ScholarPubMed
Raz, N., & Rodrigue, K.M. (2006). Differential aging of the brain: Patterns, cognitive correlates and modifiers. Neuroscience and Biobehavioral Reviews, 30, 730748.CrossRefGoogle ScholarPubMed
Salat, D.H., Kaye, J.A., & Janowsky, J.S. (2001). Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer disease. Archives of Neurology, 58, 14031408.CrossRefGoogle ScholarPubMed
Samanez-Larkin, G.R., Gibbs, S.E., Khanna, K., Nielsen, L., Carstensen, L.L., & Knutson, B. (2007). Anticipation of monetary gain but not loss in healthy older adults. Nature Neuroscience, 10, 787791.CrossRefGoogle Scholar
Sheline, Y.I., Barch, D.M., Price, J.L., Rundle, M.M., Vaishnavi, S.N., Snyder, A.Z., et al. (2009). The default mode network and self-referential processes in depression. Proceedings of the National Academy of Science of the United States of America, 106, 19421947.CrossRefGoogle ScholarPubMed
St Jacques, P.L., Dolcos, F., & Cabeza, R. (2008). Effects of aging on functional connectivity of the amygdala during negative evaluation: A network analysis of fMRI data. Neurobiology of Aging, [Epub ahead of print].Google Scholar
St Jacques, P.L., Dolcos, F., & Cabeza, R. (2009). Effects of aging on functional connectivity of the amygdala for subsequent memory of negative pictures: A network analysis of fMRI data. Psychological Science, 20, 7484.CrossRefGoogle Scholar
Tessitore, A., Hariri, A.R., Fera, F., Smith, W.G., Das, S., Weinberger, D.R., et al. (2005). Functional changes in the activity of brain regions underlying emotion processing in the elderly. Psychiatry Research, 139, 918.CrossRefGoogle ScholarPubMed
Urry, H.L., van Reekum, C.M., Johnstone, T., Kalin, N.H., Thurow, M.E., Schaefer, H.S., et al. (2006). Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults. Journal of Neuroscience, 26, 44154425.CrossRefGoogle ScholarPubMed
Williams, L.M., Brown, K.J., Palmer, D., Liddell, B.J., Kemp, A.H., Olivieri, G., et al. (2006). The mellow years? Neural basis of improving emotional stability over age. Journal of Neuroscience, 26, 64226430.CrossRefGoogle ScholarPubMed
Wright, C.I., Dickerson, B.C., Feczko, E., Negeira, A., & Williams, D. (2007). A functional magnetic resonance imaging study of amygdala responses to human faces in aging and mild Alzheimer’s disease. Biological Psychiatry, 62, 13881395.CrossRefGoogle ScholarPubMed
Wright, C.I., Negreira, A., Gold, A.L., Britton, J.C., Williams, D., & Barrett, L.F. (2008). Neural correlates of novelty and face-age effects in young and elderly adults. Neuroimage, 42, 956968.CrossRefGoogle Scholar
Wright, C.I., Wedig, M.M., Williams, D., Rauch, S.L., & Albert, M.S. (2006). Novel fearful faces activate the amygdala in healthy young and elderly adults. Neurobiology of Aging, 27, 361374.CrossRefGoogle Scholar
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