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A review of vascular disrupting agents as a concomitant anti-tumour modality with radiation

Published online by Cambridge University Press:  02 May 2013

William Tyler Tran ,
Ahmed El Kaffas ,
Azza Al-Mahrouki ,
Carol Gillies  and
Gregory Jan Czarnota
William Tyler Tran*
Affiliation:
Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Ahmed El Kaffas
Affiliation:
Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Azza Al-Mahrouki
Affiliation:
Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Carol Gillies
Affiliation:
Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada
Gregory Jan Czarnota
Affiliation:
Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada
*
Correspondence to: William Tyler Tran, Department of Radiation Oncology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, TB95, Toronto, Ontario, Cannada M4N 3M5. Tel: 416 480-6100, ext 1026. E-mail: william.tran@sunnybrook.ca.
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Abstract

Background

Tumour vasculature plays an important role in the development, maintenance and sustainability of a tumour. Endothelial cells which are recruited into the tumour stroma facilitate the formation of essential blood vessels that deliver nutrients and oxygen to tumour cells. A growing body of research is showing that there are synergistic anti-tumour effects when anti-vascular agents are combined with radiation. More recent reports have described favourable radiation response as a function of vascular targeting and blood vessel breakdown, primarily through interactions of radiation with vascular endothelial cells. Vascular disrupting agents are being utilised in several forms that include molecular targeting, biophysical assault and biological interference.

Purpose

In the present review, we examine current advances in anti-vascular agents to enhance tumour response when combined with radiation therapy.

Methods

A comprehensive literature search was conducted on the US National Library of Medicine, National Institutes of Health (PubMed) using the following search keywords: vascular disrupting agents, radiation sensitisation, anti-angiogenic therapy, anti-vascular therapy, radiation therapy.

Conclusion

Current research suggests the applicability of vascular disrupting agents as an effective radiation sensitisation agent. Pre-clinical and clinical trials have been well developed to form the theoretical framework to apply this powerful modality to the treatment of cancer.

Keywords

anti-angiogenesisanti-vascular therapycancer therapiesradiation therapyvascular disrupting agents
Type
Literature Review
Information
Journal of Radiotherapy in Practice , Volume 12 , Issue 3 , September 2013 , pp. 255 - 262
Copyright
Copyright © Cambridge University Press 2013 

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