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Can ‘boost’ be avoided in pre-invasive and early breast cancer with free surgical margins after breast conservation surgery and irradiation?

Published online by Cambridge University Press:  19 August 2011

Federico L. Ampil ,
Quyen Chu ,
Gloria Caldito ,
Benjamin D.L. Li ,
Gary V. Burton  and
Roger H. Kim
Federico L. Ampil*
Affiliation:
Department of Radiology, Louisiana State University Health Sciences CenterShreveport, Louisiana, USA
Quyen Chu
Affiliation:
Department of Surgery, Louisiana State University Health Sciences CenterShreveport, Louisiana, USA
Gloria Caldito
Affiliation:
Department of Biometry, Louisiana State University Health Sciences CenterShreveport, Louisiana, USA
Benjamin D.L. Li
Affiliation:
Department of Surgery, Louisiana State University Health Sciences CenterShreveport, Louisiana, USA
Gary V. Burton
Affiliation:
Department of Medicine, Louisiana State University Health Sciences Center, and Feist-Weiller Cancer Center, Shreveport, Louisiana, USA
Roger H. Kim
Affiliation:
Department of Surgery, Louisiana State University Health Sciences CenterShreveport, Louisiana, USA
*
Correspondence to: Federico L. Ampil, MD, Division of Therapeutic Radiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, Louisiana 71130, USA. Tel: (318) 675–5334; Fax: (318) 675–4697. E-mail: fampil@lsuhsc.edu
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Abstract

Guidelines concerning early stage breast cancer do not clearly recommend tumour bed boost dose after breast conserving surgery and irradiation when the resection margins are negative. Because the number of these patients is expected to increase, we evaluated the results of our treatment scheme in which the additional tumour bed dose was omitted. One hundred consecutive individuals with ductal carcinoma in-situ or stage I or II cancer of the breast were identified for this retrospective analysis. The observed ipsilateral breast tumour recurrence and 10-year disease-free survival rates were 4% and 91% respectively. Univariate analysis indicated that triple receptor negative tumour is the most independent prognostic risk factor. In conclusion, the observed low rate of local recurrence and many long-term survivors in this study seem to legitimize the omission of the tumour bed boost dose after whole breast irradiation in women with early carcinoma of the breast and free breast conserving surgical margins.

Keywords

Breast cancerbreast conservation surgeryradiotherapy
Type
Short Communication
Information
Journal of Radiotherapy in Practice , Volume 10 , Issue 3 , September 2011 , pp. 209 - 212
Copyright
Copyright © Cambridge University Press 2011

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References

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