Hostname: page-component-8448b6f56d-jr42d Total loading time: 0 Render date: 2024-04-25T03:33:25.542Z Has data issue: false hasContentIssue false
  • English
  • Français

A Clinical and Biochemical Study of Monoamine Oxidase Inhibition in Depressed Patients

Ii. 5-Hydroxytryptamine Tolerance Before and After Nialamide

Published online by Cambridge University Press:  08 February 2018

W. G. Dewhurst  and
C. M. B. Pare
W. G. Dewhurst
Affiliation:
Bethlem Royal and The Maudsley Hospitals
C. M. B. Pare
Affiliation:
Bethlem Royal and The Maudsley Hospitals
Get access Rights & Permissions [Opens in a new window]

Extract

In order to test whether a drug is an inhibitor of monoamine oxidase in the human subject, three main measures are available:

1. We can measure an increased excretion of the normal substrates of the enzyme, e.g. tryptamine (Sjoerdsma, et al., 1959b).

2. We can measure a decreased excretion of the metabolites resulting from the enzyme's action, e.g. 5-hydroxyindoleacetic acid (5-HIAA).

3. We can administer a loading dose of an enzyme substrate and observe how the subject deals with it before and after the drug, e.g. 5-hydroxytryptamine (Sjoerdsma et al., 1958), and epinephrine (N-methyl-C14) (Resnick et al., 1958).

Type
Original Articles
Information
Journal of Mental Science , Volume 107 , Issue 447 , March 1961 , pp. 244 - 249
Copyright
Copyright © Royal College of Psychiatrists, 1961 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Dewhurst, W. G., and Pare, C. M. B. (to be published).Google Scholar
Resnick, O., Wolfe, J. M., Freeman, H., and Elmadjian, F., Science, 1958, 127, 1116.CrossRefGoogle Scholar
Sjoerdsma, , Gillespie, L., and Udenfriend, S., Ann. N. Y. acad. Sci., 1959, 80, 969.CrossRefGoogle Scholar
Idem , Oates, J. A., Zaltman, P., and Udenfriend, S., J. Pharmacol., 1959, 126, 217.Google Scholar
Idem , Gillespie, L., and Udenfriend, S., Lancet, 1958, ii, 159.Google Scholar
Idem , Oates, J. A., and Gillespie, L., Proc. Soc. exp. Biol., N. Y., 1960 (in press).Google Scholar
Udenfriend, S., Lovenberg, W., and Sjoerdsma, A., Arch. Biochem. Biophys., 1959, 85, 487.CrossRefGoogle Scholar
Idem , Trrus, E., and Weissbach, H., J. Biol. Chem., 1955, 216, 499.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.