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Collagen-fibril matrix properties modulate the kinetics of silica polycondensation to template and direct biomineralization

Published online by Cambridge University Press:  28 January 2016

Jennifer L. Kahn
Affiliation:
Department of Agricultural & Biological Engineering, Purdue University, West Lafayette, Indiana 47907, USA; and Physiological Sensing Facility at the Bindley Bioscience Center and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA
Necla Mine Eren
Affiliation:
Department of Agricultural & Biological Engineering, Purdue University, West Lafayette, Indiana 47907, USA
Osvaldo Campanella
Affiliation:
Department of Agricultural & Biological Engineering, Purdue University, West Lafayette, Indiana 47907, USA
Sherry L. Voytik-Harbin
Affiliation:
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA; and Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
Jenna L. Rickus
Affiliation:
Department of Agricultural & Biological Engineering, Purdue University, West Lafayette, Indiana 47907, USA; Physiological Sensing Facility at the Bindley Bioscience Center and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA; and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
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Abstract

Fibrillar collagen networks template and direct biocompatible silica mineralization to produce hybrid materials for biomedical applications. Silica mineralization kinetics is critical for precision-tuning material properties, including mechanical strength, microstructure, and interface thickness. We investigated the effect of varying collagen template fibril volume fraction (0.2–0.8) and elasticity (G′ 200–1500 Pa) on silica mineralization rates. Measurement of the depletion of mono- and disilicic acids by silicomolybdic acid titration showed that silica condensation on collagen fibrils follows third-order kinetics. Resulting third-order rate constants increased linearly with storage modulus and quadratically with fibril volume fraction. A unique rheological approach used to probe the collagen template surface elasticity in real-time during silicification suggested a two-phase mechanism with high levels of surface-localized gelation in Phase 1 and high levels of bulk solution-localized gelation in Phase 2. These results provide a tool for controlling hybrid collagen-silica material properties by controlling local silica condensation rates.

Type
Biomineralization and Biomimetics Articles
Copyright
Copyright © Materials Research Society 2016 

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Footnotes

Contributing Editor: Laurie Gower

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Collagen-fibril matrix properties modulate the kinetics of silica polycondensation to template and direct biomineralization
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