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Topical aminoglycosides in the management of active mucosal chronic suppurative otitis media

Published online by Cambridge University Press:  29 June 2007

J. L. Lancaster ,
Z. G. G. Makura ,
G. Porter  and
M. McCormick
J. L. Lancaster*
Affiliation:
Department of Otolaryngology, The Royal Liverpool University Hospital, Liverpool, UK.
Z. G. G. Makura
Affiliation:
Department of Otolaryngology, The Royal Liverpool University Hospital, Liverpool, UK.
G. Porter
Affiliation:
Department of Otolaryngology, The Royal Liverpool University Hospital, Liverpool, UK.
M. McCormick
Affiliation:
Department of Otolaryngology, The Royal Liverpool University Hospital, Liverpool, UK.
*
Address for correspondence: Mr Jeffrey L. Lancaster, Department of Otolaryngology, The Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP.
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Abstract

Debate has currently re-emerged following a renewed warning issued from the Committee on the Safety of Medicines (CSM) regarding the relative risk of ototoxicity from the use of aminoglycoside-containing drops in patients with tympanic membrane perforations. We present the findings of a survey of ENT consultants, questioning their views and current practice, and we add to the debate by means of a review and discussion of the literature.

Keywords

Otitis mediasuppurativeTherapyToxicity
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 1 , January 1999 , pp. 10 - 12
Copyright
Copyright © JLO (1984) Limited 1999

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References

Browning, G. G., Gatehouse, S., Calder, I. T. (1988) Medical management of active chronic otitis media: A controlled study. Journal of Laryngology and Otology 102: 491–495.CrossRefGoogle ScholarPubMed
Current problems (1981) Committee on the Safety of Medicines publication. No. 5.Google Scholar
Current problems in pharmacovigilance (1997) Committee on the Safety of Medicines publication no. 23, pp 14–16.Google Scholar
Dumas, G., Bessord, G., Gavend, M., Cherachou, R. (1980) Risque de surdite pour installation de groubte auriculaires couteriant aminosides. Therapie 35: 357–363.Google Scholar
English, M. G., Northern, J. L., Fria, T. (1973) Chronic otitis media as a cause of sensorineural hearing loss. Archives of Oto-laryngology 98: 12–22.Google Scholar
Gehanno, P., Cohen, B. (1993) Effectiveness and safety of Ofloxacin in chronic otitis media and chronic sinusitis in adult outpatients. European Archives of Otorhinolaryngology 250: 13–14.CrossRefGoogle ScholarPubMed
Green, K. M. J., Lappin, D. W. P., Curley, J. W. A., de Carpentier, J. P. (1997) Systemic absorption of gentamicin ear drops. Journal of Laryngology and Otology 111: 960–962.CrossRefGoogle ScholarPubMed
Hulka, J. H. (1941) Bone conduction changes in acute otitis media. Archives of Oto-laryngology 33: 333–350.CrossRefGoogle Scholar
Jones, R. N., Milazzo, J., Seidlin, M. (1997) Ofloxacin otic solution for treatment of otitis externa in children and adults. Archives of Otolaryngology – Head and Neck Surgery 123(11): 1193–1200.CrossRefGoogle ScholarPubMed
Kawabata, I., Paparella, M. M. (1971) Fine structure of round window membrane. Annals of Otology, Rhinology and Laryngology 80: 13–26.CrossRefGoogle ScholarPubMed
Kenna, M. A., Bluestone, C. D., Reilly, J. S., Lusk, R. P. (1986) Medical management of chronic suppurative otitis media without cholesteatoma in children. Laryngoscope 96: 146–151.CrossRefGoogle ScholarPubMed
Marais, J., Rutka, J. A. (1998)Ototoxicity and topical ear drops. Clinical Otolaryngology 23: 360–367.CrossRefGoogle Scholar
McKelvie, P., Johnstone, I., Jamieson, I., Brooks, C. (1975) The effect of gentamicin ear drops on the cochlea. British Journal of Audiology 9: 45–47.CrossRefGoogle Scholar
Meyerhoff, W. L., Morizono, T., Wright, C. G., Shaddock, L. C., Shea, D. A., Sikora, M. A. (1983) Tympanostomy tubes and otic drops. Laryngoscope 93: 1022–1027.CrossRefGoogle ScholarPubMed
Murphy, K. W. (1970) Deafness after topical neomycin. British Medical Journal 2: 114.CrossRefGoogle ScholarPubMed
Nomura, J. (1984) Otological significance of the round window. Advances in Oto-Rhino-Laryngology (Pfoltz, C. R., ed.) Vol 33, S. Karger, New York, pp 1–162.Google Scholar
Ototoxic ear drops (1998) Clinical Otolaryngology Newsletter 98/2.Google Scholar
Paparella, M. M., Brady, D. R., Hoel, R. (1970) Sensorineural hearing loss in chronic otitis media and mastoiditis. Transactions of the American Academy of Ophthalmology and Otolaryngology 24: 108–115.Google Scholar
Paparella, M. M., Hiraide, F., Oda, M., Brady, D. (1972) Pathology of sensorineural hearing loss in otitis media. Annals of Otology, Rhinology and Laryngology 81: 632–647.CrossRefGoogle ScholarPubMed
Podoshin, L., Fradis, M., David, J. B. (1989) Ototoxicity of ear drops in patients suffering from chronic otitis media. Journal of Laryngology and Otology 103: 46–50.Google Scholar
Sumitsawan, Y., Tharavichitkul, P., Prawatmuang, W., Ingsuwan, B., Sriburi, P. (1995) Ofloxacin otic solution as treatment of chronic suppurative otitis media and diffuse bacterial otitis externa. Journal of the Medical Association of Thailand 78(9): 455–459.Google ScholarPubMed
Voldrich, L. (1965) The kinetics of streptomycin, kanamycin and neomycin in the inner ear. Acta Otolaryngologica 66: 243.CrossRefGoogle Scholar
Wintermeyer, S. M., Nahata, M. C. (1994) Chronic suppurative otitis media. Annals of Pharmacotherapy 28(9): 1089–1099.Google Scholar
Yuen, A. P. W., Chau, P. Y., Wei, W. I. (1995) Bacteriology of chronic suppurative otitis media: Ofloxacin susceptibility. Journal of Otolaryngology 24(3): 206–208.Google Scholar