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Repair of subtotal tympanic membrane perforations with Seprafilm®

Published online by Cambridge University Press:  08 March 2006

Ersin Konakçi ,
Mehmet Koyuncu ,
Recep Ünal ,
Atilla Tekat  and
Melek Uyar
Ersin Konakçi
Affiliation:
Department of Otorhinolaryngology, Ondokuz Mayis University Medical School, Kurupelit Campus, 55139, Samsun, Turkey.
Mehmet Koyuncu
Affiliation:
Department of Otorhinolaryngology, Ondokuz Mayis University Medical School, Kurupelit Campus, 55139, Samsun, Turkey.
Recep Ünal
Affiliation:
Department of Otorhinolaryngology, Ondokuz Mayis University Medical School, Kurupelit Campus, 55139, Samsun, Turkey.
Atilla Tekat
Affiliation:
Department of Otorhinolaryngology, Ondokuz Mayis University Medical School, Kurupelit Campus, 55139, Samsun, Turkey.
Melek Uyar
Affiliation:
Department of Otorhinolaryngology, Ondokuz Mayis University Medical School, Kurupelit Campus, 55139, Samsun, Turkey.
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Abstract

Objectives: We studied the experimental use of Seprafilm, a sheet-like filmform of hyaluronic acid, in the repair of subtotal perforations of the tympanic membrane (TM), and the durability of such repairs.

Method: The research was conducted on 42 Sprague–Dawley rats. Right TMs of all rats were subtotally and thermally perforated in the same fashion. Seprafilm was applied to the perforated TMs of the 21 rats comprising the experiment group. The perforated TMs of the remaining 21rats, the control group, were left to heal spontaneously.

Results: The mean healing times were recorded as 7.8 ± 0.6 days for the Seprafilm group and 14.9 ± 1.1 days for the control group (p < 0.001).

Conclusions: These results suggest that Seprafilm may be a possible first choice (before thedecision to operate) in subtotal perforations, considering its easy application and patient follow-up.

Keywords

Tympanic Membrane PerforationsHyaluronic AcidMembranes Artificial
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 118 , Issue 11 , November 2004 , pp. 862 - 865
Copyright
© 2004 Royal Society of Medicine Press

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