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Primary, combined, atypical carcinoid and squamous cell carcinoma of the larynx: a new variety of composite tumour

Published online by Cambridge University Press:  25 November 2009

C R Davies-Husband ,
P Montgomery ,
D Premachandra  and
H Hellquist
C R Davies-Husband*
Affiliation:
ENT department, Norfolk and Norwich University Hospital, Norwich, UK
P Montgomery
Affiliation:
ENT department, Norfolk and Norwich University Hospital, Norwich, UK
D Premachandra
Affiliation:
ENT department, Norfolk and Norwich University Hospital, Norwich, UK
H Hellquist
Affiliation:
Cotman Centre of Histopathology, Norwich, UK
*
Address for correspondence: Mr Cameron Ross Davies-Husband, 2 Church Road, Bardwell, Bury St Edmunds IP31 1AH, UK. E-mail: camerondh@doctors.org.uk
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Abstract

Objective:

We report the first case of a laryngeal composite tumour consisting of a squamous cell carcinoma combined with an atypical carcinoid.

Methods:

Case report and review of the literature concerning laryngeal composite tumours.

Results:

Primary laryngeal carcinoma is the most common malignancy of the upper aerodigestive tract. The vast majority are of the squamous cell type. Primary neuroendocrine neoplasms represent a rare, heterogeneous subset of laryngeal malignancies, comprising typical carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma. Primary combined neuroendocrine and squamous cell carcinoma of the larynx is even more rarely encountered, with only 14 publications of this so-called composite tumour to date. In each case, the neuroendocrine component has been small cell carcinoma.

Conclusion:

The treatment of primary neoplasms comprising more than one histological type is tailored to the most biologically aggressive tumour. Accurate diagnosis of the histological nature of laryngeal composite tumours is imperative to ensure optimal therapy.

Keywords

LarynxSquamous Cell CarcinomaAtypical CarcinoidComposite Tumour
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 2 , February 2010 , pp. 226 - 229
Copyright
Copyright © JLO (1984) Limited 2009

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Footnotes

Presented as a poster at the UK ENT Annual Academic Meeting, 5 September 2008, Royal College of Surgeons, London, UK.

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