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Primary, combined, atypical carcinoid and squamous cell carcinoma of the larynx: a new variety of composite tumour

Published online by Cambridge University Press:  25 November 2009

C R Davies-Husband ,
P Montgomery ,
D Premachandra  and
H Hellquist
C R Davies-Husband*
Affiliation:
ENT department, Norfolk and Norwich University Hospital, Norwich, UK
P Montgomery
Affiliation:
ENT department, Norfolk and Norwich University Hospital, Norwich, UK
D Premachandra
Affiliation:
ENT department, Norfolk and Norwich University Hospital, Norwich, UK
H Hellquist
Affiliation:
Cotman Centre of Histopathology, Norwich, UK
*
Address for correspondence: Mr Cameron Ross Davies-Husband, 2 Church Road, Bardwell, Bury St Edmunds IP31 1AH, UK. E-mail: camerondh@doctors.org.uk
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Abstract

Objective:

We report the first case of a laryngeal composite tumour consisting of a squamous cell carcinoma combined with an atypical carcinoid.

Methods:

Case report and review of the literature concerning laryngeal composite tumours.

Results:

Primary laryngeal carcinoma is the most common malignancy of the upper aerodigestive tract. The vast majority are of the squamous cell type. Primary neuroendocrine neoplasms represent a rare, heterogeneous subset of laryngeal malignancies, comprising typical carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma. Primary combined neuroendocrine and squamous cell carcinoma of the larynx is even more rarely encountered, with only 14 publications of this so-called composite tumour to date. In each case, the neuroendocrine component has been small cell carcinoma.

Conclusion:

The treatment of primary neoplasms comprising more than one histological type is tailored to the most biologically aggressive tumour. Accurate diagnosis of the histological nature of laryngeal composite tumours is imperative to ensure optimal therapy.

Keywords

LarynxSquamous Cell CarcinomaAtypical CarcinoidComposite Tumour
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 2 , February 2010 , pp. 226 - 229
Copyright
Copyright © JLO (1984) Limited 2009

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Footnotes

Presented as a poster at the UK ENT Annual Academic Meeting, 5 September 2008, Royal College of Surgeons, London, UK.

References

1Gianoli, GJ, Butcher, RB, Martin, EJ. Composite tumor of the larynx. Ear Nose Throat J 1992;71:81–2, 85–7Google Scholar
2Barbeaux, A, Duck, L, Weynand, B, Desuter, G, Hamoir, M, Gregoire, V et al. Primary combined squamous and small cell carcinoma of the larynx: report of two cases and discussion of treatment modalities. Eur Arch Otorhinolaryngol 2006;263:786–90CrossRefGoogle ScholarPubMed
3Chen, DA, Mandell-Brown, M, Moore, SF, Johnson, JT. “Composite” tumor: mixed squamous cell and small cell anaplastic carcinoma of the larynx. Otolaryngol Head Neck Surg 1986;95:99–103CrossRefGoogle ScholarPubMed
4Cosby, WN, Babin, RW. Simultaneous oat cell and squamous cell carcinoma of the larynx. Military Med 1988;153:196–8Google Scholar
5Eusebi, V, Betts, CM, Giangaspero, F. Primary oat cell carcinoma of the larynx. Virchows Arch A Pathol Anat Histol 1978;380:349–54Google Scholar
6Ferlito, A, Recher, G, Caruso, G. Primary combined small cell carcinoma of the larynx. Am J Otolaryngol 1985;6:302–8CrossRefGoogle ScholarPubMed
7Gnepp, DR, Ferlito, A, Hyams, V. Primary anaplastic small cell (oat cell) carcinoma of the larynx: review of the literature and report of 18 cases. Cancer 1983;51:1731–45Google Scholar
8Hirsch, FR, Matthews, MJ, Aisner, S, Campobasso, O, Elema, JD, Gazdar, AF et al. Histopathologic classification of small cell lung cancer: changing concepts and terminology. Cancer 1998;62:973–73.0.CO;2-O>CrossRefGoogle Scholar
9Jaiswal, VR, Hoang, MP. Primary combined squamous and small cell carcinoma of the larynx: a case report and review of the literature. Arch Pathol Lab Med 2004;128:1279–82Google Scholar
10Medina, JE, Moran, M, Geopfert, H. Oat cell carcinoma of the larynx and Eaton-Lambert syndrome. Arch Otolaryngol 1984;110:123–6CrossRefGoogle ScholarPubMed
11Mills, SE, Cooper, PH, Garland, TA, Johns, ME. Small cell undifferentiated carcinoma of the larynx: report of two patients and review of 13 additional cases. Cancer 1983;51:116–20Google Scholar
12Yucel, OT, Sokmensuer, C, Gedikoglu, G, Ayas, K. Combined small cell and squamous cell carcinoma of the larynx: short communication. Tumori 2001;86:434–6Google Scholar
13Fu, Y-S, Wenig, BM, Abemayor, E, Wenig, BL. Head and Neck Pathology. Philadelphia: Churchill-Livingstone, 2001;330–455Google Scholar
14Barnes, L. Neuroendocrine tumours In: Barnes, L, Eveson, JW, Reichert, P, Sidransky, D, eds. World Health Organization Classification of Tumours; Pathology and Genetics of Head and Neck Tumours. Lyon: IARC, 2005;135–9Google Scholar
15Woodruff, JM, Senie, RT. Atypical carcinoid tumor of the larynx. A critical review of the literature. ORL J Otorhinolaryngol Relat Spec 1991;53:194–209CrossRefGoogle ScholarPubMed
16Ferlito, A, Friedmann, I, Goldman, NC. Primary carcinoid tumour of the larynx. ORL J Otorhinolaryngol Relat Spec 1988;50:129–49CrossRefGoogle ScholarPubMed
17Snyderman, C, Johnson, JT, Barnes, L. Carcinoid tumor of the larynx: case report and review of the world literature. Otolaryngol Head Neck Surg 1986;95:158–64CrossRefGoogle ScholarPubMed
18Gnepp, DR. Small cell neuroendocrine carcinoma of the larynx. A critical review of the literature. ORL J Otorhinolaryngol Relat Spec 1991;53:210–19CrossRefGoogle ScholarPubMed
19Bishop, JW, Osamura, RY, Tsutsumi, Y. Multiple hormone production in an oat cell carcinoma of the larynx. Acta Pathol Jpn 1985;35:915–23Google Scholar
20Trotoux, J, Glickmanas, M, Sterkers, O, Trousset, M, Pinel, J. Schwartz-Bartter syndrome. Presentation of a sub-glottal small cell laryngeal carcinoma. Ann Otolaryngol Chir Cervicofac 1979;96:349–58Google Scholar