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The nasal manifestations of sarcoidosis: a review and report of eight cases

Published online by Cambridge University Press:  29 June 2007

N. Fergie ,
N. S. Jones  and
M. F. Havlat
N. Fergie*
Affiliation:
Department of Otorhinolaryngology, Queen's Medical Centre, Nottingham, UK
N. S. Jones
Affiliation:
Department of Otorhinolaryngology, Queen's Medical Centre, Nottingham, UK
M. F. Havlat
Affiliation:
Department of Pathology, Queen's Medical Centre, Nottingham, UK
*
Address for correspondence: N. Fergie, Department of Otorhinolaryngology, Derbyshire Royal Infirmary, London Road, Derby DEI 2QY
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Abstract

We report eight patients presenting to the Department of Otorhinolaryngology between 1990 and 1998 in whom a diagnosis of sarcoidosis was made. The most common presenting symptom was that of nasal obstruction and crusting and the most common site of involvement was the septum and inferior turbinate. These patients differ from the majority of patients who present with the other manifestations of sarcoidosis in that they are older. Where mucosal changes are present within the nose, biopsy gives a high diagnostic yield. The aim of treatment is to gain symptomatic control with the lowest dose of steroids. The majority of patient's nasal symptoms were managed with local measures and topical steroids. Nasal disease tends to follow a prolonged but benign course. Few had other organ involvement. While nasal sarcoidosis remains a rare cause of nasal obstruction, biopsy of abnormal nasal mucosa along with further investigations as dictated by history, examination and histological findings is important if delay in diagnosis is to be avoided.

Keywords

Respiratory tract diseasesNasalSarcoidosis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 10 , October 1999 , pp. 893 - 898
Copyright
Copyright © JLO (1984) Limited 1999

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References

Allen, B. R. (1978) Sarcoid of nose with collapse of nasal cartilage. British Journal of Dermatology 99(Suppl. 16): 54–56.Google Scholar
Boeck, C. (1899) Multiple benign sarkoid of the skin. Journal of Cutaneous and Genito-urinary diseases 16: 543–550.Google Scholar
Bull, T. R. (1983) Rhinoplasty: aesthetics, ethics and airway. Journal of Laryngology and Otology 97: 901–916.Google Scholar
Busuttil, A., Hopkinson, J. M. (1981) Sarcoidosis of the nasal mucosa. Journal of Laryngology and Otology 95: 1265–1270.CrossRefGoogle ScholarPubMed
Clarke, D., Mitchell, A. W. M., Dick, R., James, G. D. (1994) The radiology of sarcoidosis. Sarcoidosis 11: 90–99.Google ScholarPubMed
Coup, A. J., Hopper, I. P. (1980) Granulomatous lesions in nasal biopsies. Histopathology 4: 293–308.CrossRefGoogle ScholarPubMed
DeRemee, R. A. (1983) The roentgenographic staging of sarcoidosis: history and contemporary perspectives. Chest 83: 128–133.Google Scholar
Falkoff, R. J., Schatz, M. (1986) Nasal manifestations of systemic immunologic disorders. Ear, Nose and Throat Journal 65: 59–63.Google Scholar
Frederiksen, J. G., Jorgensen, K. (1996) Sarcoidosis of the nose treated with laser surgery. Rhinology 34: 245–246.Google ScholarPubMed
Hunninghake, G. W. (1997) Goal of the treatment for sarcoidosis. American Journal of Respiratory and Critical Care Medicine 156: 1369–1370.CrossRefGoogle ScholarPubMed
Israel, H. L., Sones, M. (1958) Sarcoidosis: clinical observations in 160 cases. Archives of Internal Medicine 12: 766–777.Google Scholar
James, D. G., Barter, S., Jash, D., MacKinnon, D. M., Carstairs, L. S. (1982) Sarcoidosis of the upper respiratory tract. Journal of Laryngology and Otology 96: 711–718.CrossRefGoogle ScholarPubMed
Kirstner, F. B., Robertson, T. D. (1938) Benign, granuloma of the nose. Journal of the American Medical Association 111: 2003–2005.CrossRefGoogle Scholar
Krespi, Y. P., Kuriloff, D. B., Aner, M. (1995) Sarcoidosis of the sinonasal tract: A new staging system. Otolaryngology – Head and Neck Surgery 112: 221–227.CrossRefGoogle ScholarPubMed
McCaffrey, T. V., McDonald, T. J. (1983) Sarcoidosis of the nose and paranasal sinuses. Laryngoscope 93: 1281–1284.CrossRefGoogle ScholarPubMed
McDonald, T. J. (1993) Manifestations of systemic disease. In Otolaryngology – Head and Neck Surgery. 2nd Edition. (Cummings, C. W., Fredrickson, J. M., Harker, L. A., Krause, C. J., Schuller, D. E., Eds.) Mosby-Year Book, Inc., St Louis, Missouri, pp 713–722.Google Scholar
Milford, C. A., Mugliston, T., Lund, V. (1990) ‘Medical rhinoplasty’ in nasal sarcoidosis. Rhinology 28: 137–139.Google Scholar
Milton, C. M. (1985) Sarcoidosis in ENT practice. Clinical Otolarynology 10: 351–355.Google Scholar
Mitchell, D. N. (1998) Sarcoidosis. Medicine 26(4): 43–49.Google Scholar
Neville, E., Mills, R. G. S., Jash, D. K., MacKinnon, D. M., Carstairs, L. S., James, D. G. (1976) Sarcoidosis of the upper respiratory tract and its association with lupus pernio. Thorax 31: 660–663.CrossRefGoogle ScholarPubMed
Patey, O., Bonnieux, P., Roucayrol, A. M., Lafaix, C. (1990) Sarcoidosis of the nose: Report of a case with nasal perforation. Sarcoidosis 7: 123–124.Google Scholar
Postma, D., Fry, T. L., Malenbaum, B. T. (1984) The nose, minor salivary glands and sarcoidosis. Archives of Otolaryngology 110: 28–30.CrossRefGoogle ScholarPubMed
Scott, P. M. J., Morphopoulus, G., Bleach, N. (1992) Augmentation rhinoplasty in nasal sarcoidosis. Journal of Laryngology and Otology 106: 544–546.Google Scholar
Shah, U. K., White, J. A., Gooey, J. E., Hybels, R. L. (1997) Otolaryngologic manifestations of sarcoidosis: presentation and diagnosis. Laryngoscope 107: 67–75.CrossRefGoogle ScholarPubMed
Shikowitz, M. J., Alvi, A. (1993) Sarcoidosis presenting as nasal obstruction. American Journal of Rhinology 7: 133–138.CrossRefGoogle Scholar
Spiteri, M. A., Matthey, F., Gordon, T., Carstairs, L. S., James, D.G. (1985) Lupus pernio: a clinico-radiological study of 35 cases. British Journal of Dermatology 112: 315–322.Google Scholar
Wilson, R., Lund, V., Sweatman, M., Mackay, I. S., Mitchell, D.N. (1988) Upper respiratory tract involvement in sarcoidosis and its management. European Respiratory Journal 1: 269–272.CrossRefGoogle ScholarPubMed