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Inflammatory myofibroblastic tumour of the tonsil: case report and literature review

Published online by Cambridge University Press:  16 February 2010

J C Magill ,
M S Ferguson ,
C R Butler ,
A Sandison  and
W E Grant
J C Magill*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Charing Cross Hospital, London, UK
M S Ferguson
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Charing Cross Hospital, London, UK
C R Butler
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Charing Cross Hospital, London, UK
A Sandison
Affiliation:
Department of Histopathology, Charing Cross Hospital, London, UK
W E Grant
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Charing Cross Hospital, London, UK
*
Address for correspondence: Dr Jennifer C Magill, Department of Otolaryngology – Head and Neck Surgery, Charing Cross Hospital, London W6 8RF, UK. Fax: +44 870 4580775 E-mail: jennifer_magill22@hotmail.com
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Abstract

Objective:

We present the first reported case in the English language literature of an inflammatory myofibroblastic tumour of the right tonsil in a young, pregnant woman, and we report a management strategy for this enigmatic entity.

Case report:

A 28-year-old, pregnant woman presented with a 10-day history of odynophagia despite a course of antibiotics. Examination revealed a grade II, erythematous right tonsil with ulceration on the upper pole. A biopsy was arranged, and initial evaluation was suggestive of spindle cell carcinoma. However, this diagnosis was reviewed after immunohistochemical staining confirmed an inflammatory myofibroblastic tumour. Subsequent complete excision was undertaken using CO2 laser.

Conclusion:

Clinically, inflammatory myofibroblastic tumour of the tonsil is known to be locally aggressive and can present in a manner not dissimilar to a high grade carcinoma of the tonsil. As a result, the recommended treatment is complete local excision with careful follow up.

Keywords

Tonsil NeoplasmsInflammatory Myofibroblastic Tumour
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 10 , October 2010 , pp. 1123 - 1125
Copyright
Copyright © JLO (1984) Limited 2010

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Footnotes

Presented at the 136th Semon Club Meeting, 14 November 2008, Guy's Hospital, London.

References

1Weiss, SW, Goldblum, JR. Benign fibrous tissue tumours. In: Enzinger and Weiss's Soft Tissue Tumours, 4th edn. Mosby, St. Louis, 2001;247–308Google Scholar
2Coffin, CM, Fletcher, JA. Inflammatory myofibroblastic tumour. In: Fletcher, CDM, Unni, KK, Mertens, F, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. International Agency for Research on Cancer Press, Lyon: World Health Organization, 2002;91–3Google Scholar
3Umiker, WO, Iverson, L. Postinflammatory tumours of the lung; report of four cases simulating xanthoma, fibroma or plasma cell tumour. J Thorac Surg 1954;28:55–63CrossRefGoogle ScholarPubMed
4Coffin, CM, Watterson, J, Priest, JR, Dehner, LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995;19:859–72CrossRefGoogle ScholarPubMed
5Batsakis, JG. Plasma cell tumours of the head and neck. Ann Rhinol Laryngol 1983;92:311–13CrossRefGoogle ScholarPubMed
6Gangopadhyay, K, Mahasin, ZZ, Kfoury, H, Ali, MA. Inflammatory myofibroblastic tumour of the tonsil. J Laryngol Otol 1997;111:880–2CrossRefGoogle ScholarPubMed
7Newman, JP, Shinn, JB. Inflammatory pseudotumour of the tonsil. Otolaryngol Head Neck Surg 1995;113:798–801CrossRefGoogle ScholarPubMed
8Weilbaecher, TG, Sharma, DP. Plasma cell granuloma of the tonsil. J Surg Oncol 1984;27:228–31CrossRefGoogle ScholarPubMed
9Coffin, CM, Patel, A, Perkins, S, Elenitoba-Johnson, KS, Perlman, E, Griffin, CA. ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumour. Mod Pathol 2001;14:569–76CrossRefGoogle Scholar
10Meiss, JM, Enzinger, FM. Inflammatory fibrosarcoma of the mesentry and retroperitoneum. A tumour closely simulating inflammatory pseudotumour. Am J Surg Pathol 1991;15:1146–56CrossRefGoogle Scholar
11Lattuada, D, Mangioni, S, Viganò, P, Ntrivalas, EI, Rossi, M, Palotti, F et al. The placental immunomodulatory cytokine regeneration and tolerance factor is also expressed by both human cycling and early pregnant endometrium. Am J Reprod Immunol 2004;52:224–31CrossRefGoogle ScholarPubMed
12Kudo, Y, Boyd, CA, Spyropoulou, I, Redman, CW, Takikawa, O, Katsuki, T et al. Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta. J Reprod Immunol 2004;61:87–98CrossRefGoogle ScholarPubMed
13Agrawal, S, Pandey, MK. The potential role of HLA-G polymorphism in maternal tolerance to the developing fetus. J Hematother Stem Cell Res 2003;12:749–56CrossRefGoogle Scholar
14Honig, A, Rieger, L, Kapp, M, Sutterlin, M, Dietl, J, Kammerer, U. Indoleamine 2,3-dioxygenase (IDO) expression in invasive extravillous trophoblast supports role of the enzyme for materno-fetal tolerance. J Reprod Immunol 2004;61:79–86CrossRefGoogle ScholarPubMed